Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease.

Animals; Disease; Gene Expression Regulation/genetics; Genetic Variation/genetics; Humans; MicroRNAs/genetics; Phenotype; Polymorphism, Genetic/genetics

Abstract :

[en] The expression of at least a third of mammalian genes is post-transcriptionally fine-tuned by approximately 1000 microRNAs (miRNAs), assisted by the RNA silencing machinery, comprising tens of components. Polymorphisms and mutations in the corresponding sequence space (machinery, miRNA precursors and target sites) are likely to make a significant contribution to phenotypic variation, including disease susceptibility. Here we review basic miRNA biology in animals, survey the available evidence for DNA sequence polymorphisms affecting miRNA-mediated gene regulation and thus phenotype, and discuss their possible importance in the determination of complex traits.

Disciplines :

Genetics & genetic processes

Author, co-author :

Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Coppieters, Wouter ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Charlier, Carole ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Language :

English

Title :

Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease.

Publication date :

2007

Journal title :

Current Opinion in Genetics and Development

ISSN :

0959-437X

eISSN :

1879-0380

Publisher :

Elsevier, Netherlands

Volume :

Issue :

Pages :

166-76

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 09 November 2011

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50 (4 by ULiège)

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2 (2 by ULiège)

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Scopus citations^®

127

Scopus citations^®
without self-citations

126

OpenCitations

106

OpenAlex citations

140

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