Article (Scientific journals)
Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease.
Georges, Michel; Coppieters, Wouter; Charlier, Carole
2007In Current Opinion in Genetics and Development, 17 (3), p. 166-76
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Keywords :
Animals; Disease; Gene Expression Regulation/genetics; Genetic Variation/genetics; Humans; MicroRNAs/genetics; Phenotype; Polymorphism, Genetic/genetics
Abstract :
[en] The expression of at least a third of mammalian genes is post-transcriptionally fine-tuned by approximately 1000 microRNAs (miRNAs), assisted by the RNA silencing machinery, comprising tens of components. Polymorphisms and mutations in the corresponding sequence space (machinery, miRNA precursors and target sites) are likely to make a significant contribution to phenotypic variation, including disease susceptibility. Here we review basic miRNA biology in animals, survey the available evidence for DNA sequence polymorphisms affecting miRNA-mediated gene regulation and thus phenotype, and discuss their possible importance in the determination of complex traits.
Disciplines :
Genetics & genetic processes
Author, co-author :
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Coppieters, Wouter ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Charlier, Carole  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Language :
English
Title :
Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease.
Publication date :
2007
Journal title :
Current Opinion in Genetics and Development
ISSN :
0959-437X
Publisher :
Elsevier, Netherlands
Volume :
17
Issue :
3
Pages :
166-76
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 November 2011

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