Article (Scientific journals)
Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomes.
Van Laere, Anne-Sophie; Coppieters, Wouter; Georges, Michel
2008In Genome Research, 18 (12), p. 1884-95
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Keywords :
Animals; Base Pairing; Base Sequence; Cattle; Chromosome Mapping; Chromosomes, Mammalian; DNA/genetics/isolation & purification; Evolution, Molecular; Female; Male; Mammals/genetics; Molecular Sequence Data; Mutation; Recombination, Genetic; X Chromosome; Y Chromosome
Abstract :
[en] Here, we report the sequence characterization of the bovine pseudoautosomal boundary (PAB) and its neighborhood. We demonstrate that it maps to the 5' end of the GPR143 gene, which has concomitantly lost upstream noncoding exons on the Y chromosome. We show that the bovine PAB was created approximately 20.7 million years ago by illegitimate intrachromatid recombination between inverted, ruminant-specific Bov-tA repeats. Accordingly, we demonstrate that cattle share their PAB with all other examined ruminants including sheep, but not with cetaceans or more distantly related mammals. We provide evidence that, since its creation, the ancestral ruminant PAB has been displaced by attrition, which occurs at variable rates in different species, and that it is capable of retreat by attrition erasure. We have estimated the ratio of male to female mutation rates in the Bovidae family as approximately 1.7, and we provide evidence that the mutation rate is higher in the recombining pseudoautosomal region than in the adjacent, nonrecombining gonosome-specific sequences.
Disciplines :
Genetics & genetic processes
Author, co-author :
Van Laere, Anne-Sophie  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Coppieters, Wouter ;  Université de Liège - ULiège > Département de productions animales > Département de productions animales
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Language :
English
Title :
Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomes.
Publication date :
2008
Journal title :
Genome Research
ISSN :
1088-9051
eISSN :
1549-5469
Publisher :
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, United States - New York
Volume :
18
Issue :
12
Pages :
1884-95
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 November 2011

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