Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: Revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14
[en] A maximum-likelihood QTL mapping method that simultaneously exploits linkage and linkage disequilibrium and that is applicable in outbred half-sib pedigrees is described. The method is applied to fine map a QTL with major effect on milk fat content in a 3-cM marker interval on proximal BTA14. This proximal location is confirmed by applying a haplotype-based association method referred to as recombinant ancestral haplotype analysis. The origin of the discrepancy between the QTL position derived in this work and that of a previous analysis is examined and shown to be due to the existence of distinct marker haplotypes associated with QTL alleles having large substitution effects.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Farnir, Frédéric ; Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale
Grisart, B.
Coppieters, Wouter ; Université de Liège - ULiège > Département de productions animales > Département de productions animales
Riquet, J.
Berzi, P.
Cambisano, Nadine ; Université de Liège - ULiège > Département de productions animales > Génomique animale
Karim, Latifa ; Université de Liège - ULiège > Département de productions animales > Génomique animale
Mni, Myriam ; Université de Liège - ULiège > Département de productions animales > Génomique animale
Moisio, S.
Simon, P.
Wagenaar, D.
Vilkki, J.
Georges, Michel ; Université de Liège - ULiège > Département de productions animales > Génomique animale
Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: Revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14
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