The long and winding road from correlation to causation.

[en] Follow-up studies of a Crohn's disease risk locus encompassing IRGM have revealed unexpected complexity. A new study shows that a synonymous variant in the IRGM coding region alters a binding site for miR-196 and modulates IRGM-dependent autophagy, adding to the list of possible mechanisms by which this locus influences disease risk.

Disciplines :

Genetics & genetic processes

Author, co-author :

Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Language :

English

Title :

The long and winding road from correlation to causation.

Publication date :

February 2011

Journal title :

Nature Genetics

ISSN :

1061-4036

eISSN :

1546-1718

Publisher :

Nature Publishing Group, New York, United States - New York

Volume :

Issue :

Pages :

180-1

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 November 2011

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Bibliography

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