The long and winding road from correlation to causation.

[en] Follow-up studies of a Crohn's disease risk locus encompassing IRGM have revealed unexpected complexity. A new study shows that a synonymous variant in the IRGM coding region alters a binding site for miR-196 and modulates IRGM-dependent autophagy, adding to the list of possible mechanisms by which this locus influences disease risk.

Disciplines :

Genetics & genetic processes

Author, co-author :

Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Language :

English

Title :

The long and winding road from correlation to causation.

Publication date :

February 2011

Journal title :

Nature Genetics

ISSN :

1061-4036

eISSN :

1546-1718

Publisher :

Nature Publishing Group, New York, United States - New York

Volume :

Issue :

Pages :

180-1

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 November 2011

Statistics

Number of views

60 (17 by ULiège)

Number of downloads

5 (4 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Franke, A. et al. Nat. Genet. 42, 1118-1125 (2010).
Brest, P. et al. Nat. Genet. 43, 242-245 (2011).
Parkes, M. et al. Nat. Genet. 39, 830-832 (2007).
Prescott, N.J. et al. Hum. Mol. Genet. 19, 1828-1839 (2010).
Bekpen, C. et al. PLoS Genet. 5, e1000403 (2009).
Singh, S.B. et al. Science 313, 1438-1441 (2006).
Levine, B. & Deretic, V. Nat. Rev. Immunol. 7, 767-777 (2007).
Hampe, J. et al. Nat. Genet. 39, 207-211 (2007).
Rioux, J.D. et al. Nat. Genet. 39, 596-604 (2007).
McCarroll, S.A. et al. Nat. Genet. 40, 1107-1112 (2008).
Singh, S.B. et al. Nat. Cell Biol. 12, 1154-1165 (2010).
Takeda, H. et al. RNA 16, 1854-1863 (2010).
Momozawa, Y. et al. Nat. Genet. 43, 43-47 (2011).
Yamazaki, K. et al. Gut 58, 228-232 (2009).