[en] [18F]FBEM, i.e. N-[2-(4-[18F]fluorobenzamido)ethyl]maleimide, is a useful synthon employed for the specific radiolabeling of thiol containing compounds, including peptides and proteins. The aim of the present work was to develop a fast, reproducible and fully automated synthesis of this compound in order to improve its availabilty as well as for obvious radioprotection matters.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Chemistry
Author, co-author :
Paris, Jérôme ; Université de Liège - ULiège > Centre de recherches du cyclotron
Thonon, David ; Université de Liège - ULiège > Centre de recherches du cyclotron
Kaisin, Geoffroy ; Université de Liège - ULiège > Centre de recherches du cyclotron
Goblet, David ; Université de Liège - ULiège > Centre de recherches du cyclotron
Goukens, Eve ; Université de Liège - ULiège > Services administratifs généraux > Contrôle physique des radiations (SUCPR)
Lacroix, Simon
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse
Language :
English
Title :
Automated synthesis of [18F] FBEM for labeling of thiol containing compounds
Publication date :
01 September 2011
Event name :
19th International Symposium on Radiopharmaceutical Sciences (ISRS)
