![]() ![]() | dos Prazeres, J. L., Almeida, A. A., Carvalho, R. P. R., Maia Ladeira, L. C., de Souza Costa, L. P., Kohlhoff, M., de Oliveira, L. L., Machado-Neves, M., & Leite, J. P. V. (2025). Exploring the safety parameters of Athenaea velutina ethanolic extract: a step towards harnessing its medicinal potential. Toxicological Research. doi:10.1007/s43188-024-00276-7 ![]() |
![]() ![]() | Staumont, B., Maia Ladeira, L. C., Gamba, A., Heusinkveld, H. J., Piersma, A., Fritsche, E., Masereeuw, R., Vanhaecke, T., Teunis, M., Luechtefeld, T., Hartung, T., Jover, R., Vinken, M., & Geris, L. (2025). Mapping physiology: a systems biology approach for the development of alternative methods in toxicology. ALTEX: Alternatives to Animal Experimentation. doi:10.5281/zenodo.14278276 ![]() |
![]() ![]() | Niarakis, A., Laubenbacher, R., An, G., Ilan, Y., Fisher, J., Flobak, Å., Reiche, K., Rodríguez Martínez, M., Geris, L., Maia Ladeira, L. C., Veschini, L., Blinov, M. L., Messina, F., Fonseca, L. L., Ferreira, S., Montagud, A., Noël, V., Marku, M., Tsirvouli, E., ... Glazier, J. A. (30 November 2024). Immune digital twins for complex human pathologies: applications, limitations, and challenges. NPJ Systems Biology and Applications, 10 (1), 141. doi:10.1038/s41540-024-00450-5 ![]() |
![]() ![]() | Santana, F. D. F. V., Da Silva, J., Lozi, A. A., Araujo, D. C., Maia Ladeira, L. C., De Oliveira, L. L., & Da Matta, S. L. P. (December 2023). Toxicology of arsenate, arsenite, cadmium, lead, chromium, and nickel in testes of adult Swiss mice after chronic exposure by intraperitoneal route. Journal of Trace Elements in Medicine and Biology, 80, 127271. doi:10.1016/j.jtemb.2023.127271 ![]() |
![]() ![]() | Dias, F. C. R., Cupertino, M. C., Silva, P. G., Oliveira, E. L., Maia Ladeira, L. C., Matta, S. L. P., Otoni, W. C., & Gomes, M. L. M. (2023). Exposure to Pfaffia glomerata causes oxidative stress and triggers hepatic changes. Brazilian Journal of Biology, 83, 271425. doi:10.1590/1519-6984.271425 ![]() |
![]() ![]() | de Paula Dias Moreira, L., Enes, B. R. N., de São José, V. C. P. B., Toledo, R. C. L., Maia Ladeira, L. C., Cardoso, R. R., da Silva Duarte, V. C., Hermsdorff, H. H. M., de Barros, F. A. R., & Martino, H. R. S. D. (21 January 2022). Chia (Salvia hispanica L.) Flour and Oil Ameliorate Metabolic Disorders in the Liver of Rats Fed a High-Fat and High Fructose Diet. Foods, 11 (3), 285. doi:10.3390/foods11030285 ![]() |
![]() ![]() | Castro, T. L. P. A. E., Maia Ladeira, L. C., Santos, C. F. F., de Deus, F. A. N., Gomes, A. R., Bastos, D. S. S., Souza, A. C. U. F., & dos Santos, E. R. C. (27 July 2021). Chronic caffeine use does not influence behavior and brain oxidative status in mice. Revista da Associação Brasileira de Nutrição, 12 (2), 146–166. doi:10.47320/rasbran.2021.2014 ![]() |
![]() ![]() | de Souza, F. B., Novaes, R. M. D., Santos, C. F. F., de Deus, F. A., Santos, F. C., Maia Ladeira, L. C., Gonçalves, R. V., Bastos, D. S. S., Souza, A. C. U. F., Machado-Neves, M., & dos Santos, E. R. C. (01 July 2021). High-fat diet and caffeine interact to modulate bone microstructure and biomechanics in mice. Life Sciences, 276 (March), 119450. doi:10.1016/j.lfs.2021.119450 ![]() |
![]() ![]() | Guimarães-Ervilha, L. O. V., Maia Ladeira, L. C., Carvalho, R. P. R., Bento, I. P. D. S., Bastos, D. S. S., Souza, A. C. U. F., Santos, E. R. C., de Oliveira, L. L., Maldonado, I. R. D. S. C., & Machado-Neves, M. (29 June 2021). Green Tea Infusion Ameliorates Histological Damages in Testis and Epididymis of Diabetic Rats. Microscopy and Microanalysis, 27 (5), 1133–1145. doi:10.1017/S1431927621012071 ![]() |
![]() ![]() | Maia Ladeira, L. C., dos Santos, E. R. C., Santos, T. A., da Silva, J., Lima, G. D. D. A., Machado-Neves, M., da Silva, R. C., Freitas, M. B., & Maldonado, I. R. D. S. C. (28 June 2021). Green tea infusion prevents diabetic nephropathy aggravation in recent-onset type 1 diabetes regardless of glycemic control. Journal of Ethnopharmacology, 274 (January), 114032. doi:10.1016/j.jep.2021.114032 ![]() |
![]() ![]() | MARRIEL, N. B., Maia Ladeira, L. C., ARAÚJO, R. D. S., da SILVA, J., MARTINS, A. L. P., & TAVARES, M. G. (08 June 2021). Playfulness in the Teaching of Cell Biology: possibilities in higher education. Elo, 10, 1–11. doi:10.21284/elo.v10i.12290 ![]() |
![]() ![]() | Mishima, M. D. V., Maia Ladeira, L. C., da Silva, B. R. P., Toledo, R. C. L., de Oliveira, T. S. V., Costa, N. M. B., & Martino, H. R. S. D. (15 February 2021). Cardioprotective action of chia ( Salvia hispanica L.) in ovariectomized rats fed a high fat diet. Food and Function, 12 (7), 3069–3082. doi:10.1039/D0FO03206A ![]() |
![]() ![]() | Mouro, V. G. S., Maia Ladeira, L. C., Lozi, A. A., de Medeiros, T. S., Silva, M. R., de Oliveira, E. L., de Melo, F. C. S. A., & da Matta, S. R. L. P. (05 January 2021). Different Routes of Administration Lead to Different Oxidative Damage and Tissue Disorganization Levels on the Subacute Cadmium Toxicity in the Liver. Biological Trace Element Research, 199 (12), 4624–4634. doi:10.1007/s12011-020-02570-5 ![]() |
![]() ![]() | Maia Ladeira, L. C., dos Santos, E. R. C., Valente, G. E., da Silva, J., Santos, T. A., & dos Santos Costa Maldonado, I. R. (25 October 2019). Could biological tissue preservation methods change chemical elements proportion measured by energy dispersive X-ray spectroscopy? Biological Trace Element Research, 196 (1), 168–172. doi:10.1007/s12011-019-01909-x ![]() |
![]() ![]() | Gamba, A., Maia Ladeira, L. C., Barnes, D. A., Janssen, M. J., Masereeuw, R., Geris, L., & Staumont, B. (September 2024). P05-50 Using ontology map and physiological map to improve predictive models for kidney toxicity. Toxicology Letters, 399, 151-S152. doi:10.1016/j.toxlet.2024.07.385 ![]() |
![]() ![]() | Maia Ladeira, L. C., Mazein, A., Ostaszewski, M., Verhoeven, A., Kuchovská, E., Sanz-Serrano, J., Drees, A., Reiche, K., Sewald, K., Fritsche, E., Vinken, M., Geris, L., & Staumont, B. (September 2024). OS02-03 Using a systems biology approach to construct adverse outcome pathway networks aligned with the FAIR principles. Toxicology Letters, 399, 58. doi:10.1016/j.toxlet.2024.07.164 ![]() |
![]() ![]() | Kuchovska, E., Maia Ladeira, L. C., Bartmann, K., Polozij, D., Gorts, N., Corek, E., Donmez, A., Saborowski, L.-C., Bendt, F., Schade, M., Raad, G., Gamba, A., Staumont, B., Bal-Price, A., Wojewodzic, M., Lislien, M., Impelizzeri, A., Hofer, T., Dirven, H., ... Fritsche, E. (September 2024). S05-01 Functional mapping of neurodevelopmental disorders to ontology-based DNT NAMs for Next Generation Risk Assessment of chemicals. Toxicology Letters, 399, 18. doi:10.1016/j.toxlet.2024.07.056 ![]() |
![]() ![]() | Kuchovska, E., Maia Ladeira, L. C., Hayot, G., Martinez, R., Islam, B., Veltman, K., Zajac, J. D., Ormanin-Lewandowska, A., Mone, M., Kandarova, H., Tangianu, S., Palloca, G., & Busquet, F. (September 2024). P02-04 ASPIS Academy: empowering the next generation of toxicologists. Toxicology Letters, 399, 105. doi:10.1016/j.toxlet.2024.07.274 ![]() |
![]() ![]() | Staumont, B., Maia Ladeira, L. C., Gamba, A., Verhoeven, A., Serrano, J. S., Kuchovska, E., Berkhout, J., A., D., Teunis, M., Luechtefeld, T. H., Hartung, T., Jover, R., Vanhaecke, T., Fritsche, E., Heusinkveld, H. J., Piersma, A., Masereeuw, R., Vinken, M., & Geris, L. (September 2024). P05-45 Ontology maps: data integration tools for applications in toxicology. Toxicology Letters, 399, 149-S150. doi:10.1016/j.toxlet.2024.07.380 ![]() |
Staumont, B., Maia Ladeira, L. C., Gamba, A., Verhoeven, A., Sanz-Serrano, J., Kuchovska, E., Berkhout, J., Barnes, D. A., Janssen, M. J., Teunis, M., Luechtefeld, T. H., Hartung, T., Jover, R., Vanhaecke, T., Fritsche, E., Heusinkveld, H. J., Piersma, A., Masereeuw, R., Vinken, M., & Geris, L. (2024). Mapping Physiology As A Basis For Building Disease Ontology Maps. In 22ND INTERNATIONAL CONGRESS ESTIV BOOK OF ABSTRACTS. ESTIV. ![]() |
Staumont, B., Maia Ladeira, L. C., Gamba, A., Verhoeven, A., Sanz-Serrano, J., Kuchovska, E., Berkhout, J., Barnes, D. A., Teunis, M., Luechtefeld, T., Hartung, T., Jover, R., Vanhaecke, T., Fritsche, E., Heusinkveld, H. J., Piersma, A., Masereeuw, R., Vinken, M., & Geris, L. (2024). From physiological maps to disease ontology maps using a systems biology approach. In Book of Abstracts. 3rd Annual Meeting of the ONTOX Project. ZENODO. ![]() |
Staumont, B., Maia Ladeira, L. C., Gamba, A., Verhoeven, A., Sanz-Serrano, J., Kuchovska, E., Berkhout, J., Barnes, D. A., Teunis, M., Luechtefeld, T., Hartung, T., Jover, R., Vanhaecke, T., Fritsche, E., Heusinkveld, H. J., Piersma, A., Masereeuw, R., Vinken, M., & Geris, L. (2024). Building disease ontology maps: in silico tools for applications in toxicology. In VPH Conference 2024 Book of Abstracts. VPH2024. ![]() |
![]() ![]() | Berkhout, J. H., Piersma, A., Legler, J., Gamba, A., Maia Ladeira, L. C., Staumont, B., Lesage, R., Geris, L., Knudsen, T. B., Spencer, R. M., & Heusinkveld, H. J. (September 2023). P06-05: Towards a virtual embryo: Computational modelling of neural tube closure defects. Toxicology Letters, 384, 106. doi:10.1016/s0378-4274(23)00510-6 ![]() |
![]() ![]() | Gamba, A., Maia Ladeira, L. C., Lesage, R., Barnes, D. A., Janssen, M. J., Teunis, M., Masereeuw, R., Geris, L., & Staumont, B. (September 2023). P06-36: The nephron physiological map as a tool to build kidney disease ontologies. Toxicology Letters, 384, 119. doi:10.1016/s0378-4274(23)00539-8 ![]() |
![]() ![]() | Maia Ladeira, L. C., Kuchovská, E., Görts, N., Hofer, T., Myhre, O., Lopez Soop, G. L. S., Dirven, H., Gamba, A., Lesage, R., Fritsche, E., Geris, L., & Staumont, B. (September 2023). LP-24: The Cognitive Function Defects Ontology: Integrating Biological, Toxicological, and Chemical Data for Next-Generation Risk Assessment. Toxicology Letters, 384, 316-S317. doi:10.1016/s0378-4274(23)00989-x ![]() |
![]() ![]() | Kuchovska, E., Bartmann, K., Maia Ladeira, L. C., Dönmez, A., Saborowski, L.-C., Bendt, F., Schade, M., Raad, G., Lesage, R., Gamba, A., Staumont, B., Geris, L., & Fritsche, E. (September 2023). P22-35: Mapping of DNT NAMs’ signaling pathways in human physiology and disease for regulatory application. Toxicology Letters, 384, 264. doi:10.1016/s0378-4274(23)00868-8 ![]() |
![]() ![]() | Maia Ladeira, L. C., Gamba, A., Lesage, R. L., Verhoeven, A., van Ertvelde, J., Jiang, J., Roodzant, D. L., Teunis, M., Jover, R., Vanhaecke, T., Vinken, M., Heuseinkveld, H., Geris, L., & Staumont, B. (2022). Designing physiological maps as a tool to study liver toxicology. In Helena Kandarova & João Barroso, 21st International Congress ESTIV Abstract Book. Bratslava, Slovakia: ESTIV. ![]() |
![]() ![]() | Barnes, D., Irvine, A., Gamba, A., Maia Ladeira, L. C., Staumont, B., Yang, H., Steffensen, I.-L., Geris, L., Janssen, M., & Masereeuw, R. (2022). Development of an adverse outcome pathway for kidney tubular necrosis. In Helena Kandarova & João Barroso, 21st International Congress ESTIV Abstract Book. Bratslava, Slovakia: ESTIV. ![]() |
![]() ![]() | Berkhout, J., Piersma, A., Legler, J., Gamba, A., Maia Ladeira, L. C., Staumont, B., Lesage, R. L., Geris, L., & Heuseinkveld, H. (2022). Computational modelling of neural tube closure defects. In Helena Kandarova & João Barroso, 21st International Congress ESTIV Abstract Book. Bratslava, Slovakia: ESTIV. ![]() |
![]() ![]() | Maia Ladeira, L. C., Gamba, A., Lesage, R. L., Verhoeven, A., Jiang, J., van Ertvelde, J., Jover, R., Vanhaecke, T., Mathieu, V., Geris, L., & Staumont, B. (2022). Developing a physiological map as a framework to study chemical- induced liver steatosis. In VPHi, VPH2022 Virtual Physiological Human Conference. Brussels, Belgium: VPHi. ![]() |
![]() ![]() | Gamba, A., Maia Ladeira, L. C., Lesage, R. L., Roodzant, D. L., Barnes, D. A., Janssen, M. J., Teunis, M., Masereeuw, R., Geris, L., & Staumont, B. (2022). From Physiological Map to Ontology Unravelling Kidney Toxicity From Physiological Map to Ontology Unravelling Kidney Toxicity. In VPHi, VPH2022 Virtual Physiological Human Conference. Brussels, Belgium: VPHi. ![]() |
![]() ![]() | Maia Ladeira, L. C., Gamba, A., Lesage, R., Ertvelde, J. V., Jiang, J., Verhoeven, A., Roodzant, D., Teunis, M., Jover, R., Vanhaecke, T., Vinken, M., Geris, L., & Staumont, B. (September 2022). P11-09 Physiology-based framework to study chemical-induced cholestasis. Toxicology Letters, 368, 165-S166. doi:10.1016/j.toxlet.2022.07.459 ![]() |
![]() ![]() | Kuchovska, E., Gamba, A., Maia Ladeira, L. C., Staumont, B., Lesage, R., Steffensen, I.-L., Soop, G. L., Hofer, T., Myhre, O., Dirven, H., Geris, L., & Fritsche, E. (September 2022). SOC-II-09 First steps for creating an ontology for cognitive function defects for regulatory application. Toxicology Letters, 368, 35-S36. doi:10.1016/j.toxlet.2022.07.112 ![]() |
![]() ![]() | Staumont, B., Maia Ladeira, L. C., Gamba, A., Lesage, R., Verhoeven, A., Jiang, J., Ertvelde, J. V., Barnes, D. A., Janssen, M. J., Kuchovska, E., Berkhout, J., Roodzant, D., Teunis, M., Bozada, T., Luechtefeld, T. H., Jover, R., Vanhaecke, T., Vinken, M., Masereeuw, R., ... Geris, L. (September 2022). SOC-VI-08 Physiological maps: a benchmark tool for adverse outcome pathways and a cornerstone for the development of disease ontologies. Toxicology Letters, 368, 77-S78. doi:10.1016/j.toxlet.2022.07.228 ![]() |
![]() ![]() | Barnes, D., Irvine, A., Gamba, A., Staumont, B., Maia Ladeira, L. C., Yang, H., Steffensen, I.-L., Geris, L., Janssen, M., & Masereeuw, R. (September 2022). P01-07 Development of an adverse outcome pathway for kidney tubular necrosis. Toxicology Letters, 368, 86-S87. doi:10.1016/j.toxlet.2022.07.251 ![]() |
![]() ![]() | Gamba, A., Maia Ladeira, L. C., Lesage, R., Barnes, D. A., Roodzant, D., Teunis, M., Janssen, M. J., Masereeuw, R., Geris, L., & Staumont, B. (2022). P04-06 New approaches for evaluating kidney toxicity using physiological maps. Toxicology Letters. doi:10.1016/j.toxlet.2022.07.290 ![]() |
Maia Ladeira, L. C., Mazein, A., Ostaszewski, M., Verhoeven, A., Sanz-Serrano, J., Drees, A. H., Vanhaecke, T., Vinken, M., Geris, L., & Staumont, B. (March 2024). Semi-automated workflow to accelerate AOP network construction using SBGN elements: a pilot study [Paper presentation]. 8th Disease Maps Community Meeting. ![]() |
![]() ![]() | Kuchovska, E., Gamba, A., Maia Ladeira, L. C., Staumont, B., Lesage, R. L., Steffensen, I.-L., Soop, G. L., Hofer, T., Myhre, O., Dirven, H., Geris, L., & Fritsche, E. (24 November 2022). FIRST STEPS FOR CREATING AN ONTOLOGY FOR COGNITIVE FUNCTION DEFECTS FOR REGULATORY APPLICATION [Poster presentation]. 21st International Congress ESTIV, Sitges, Spain. ![]() |
![]() ![]() | Maia Ladeira, L. C.* , Gamba, A.* , Lesage, R., Kuchovska, E., Görts, N., Verhoeven, A., Jiang, J., van Ertvelde, J., Barnes, D., Janssen, M., Berkhout, J., Roodzant, D., Teunis, M., Bozada, T. J., Luechtefeld, T., Jover, R., Vanhaecke, T., Vinken, M., Masereeuw, R., ... Staumont, B. (24 November 2022). Physiological maps and chemical-induced disease ontologies: tools to support NAMs development for next-generation risk assessment [Poster presentation]. ASPIS Open Symposium, Sitges, Spain. ![]() * These authors have contributed equally to this work. |
![]() ![]() | Gamba, A., Maia Ladeira, L. C., Lesage, R., Roodzant, D., Barnes, D., Janssen, M., Teunis, M., Masereeuw, R., Geris, L., & Staumont, B. (20 October 2022). Physiological map to study kidney toxicity in the ONTOX project [Poster presentation]. 21st International Congress ESTIV, Sitges, Spain. ![]() |
![]() ![]() | Messina, F., Rotondo, C., Maia Ladeira, L. C., Properzi, M., Dimartino, V., Riccitelli, B., Staumont, B., Chilemi, G., Geris, L., Bocci, M. G., & Fontana, C. (2024). Building a model of sepsis: data integration unravels pathogenic mechanisms in severe P. aeruginosa infections. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/327015. doi:10.1101/2024.10.17.618881 |
Maia Ladeira, L. C., dos Santos, E. C., Mendes, B. F., Gutierrez, E. A., Santos, C. F. F., de Souza, F. B., Machado-Neves, M., & Maldonado, I. R. D. S. C. (2020). Green tea infusion aggravates nutritional status of the juvenile untreated STZ-induced type 1 diabetic rat. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/327031. doi:10.1101/2020.01.13.904896 |