Profil

Tielens Sylvia

GIGA Neurosciences - Molecular Regulation of Neurogenesis

Département des sciences biomédicales et précliniques

See author's contact details
ORCID
0000-0002-7504-4206
Main Referenced Co-authors
Nguyen, Laurent  (32)
Chariot, Alain  (13)
Laguesse, Sophie  (11)
Boutsen, Anaïs  (9)
Charlet-Briart, Manon  (7)
Main Referenced Keywords
Humans (3); Biochemistry, Genetics and Molecular Biology (all) (2); Female (2); General Biochemistry, Genetics and Molecular Biology (2); Sample preparation (2);
Main Referenced Unit & Research Centers
GIGA Stem Cells (1)
MolSys - Molecular Systems - ULiège (1)
Main Referenced Disciplines
Neurology (24)
Biochemistry, biophysics & molecular biology (6)
Life sciences: Multidisciplinary, general & others (4)
Chemistry (4)
Immunology & infectious disease (2)

Publications (total 42)

The most downloaded
455 downloads
Chen, D., Nemazanyy, I., Peulen, O., Shostak, K., Xu, X., Tang, S. C., Wathieu, C., Turchetto, S., Tielens, S., Nguyen, L., Close, P., Desmet, C., Klein, S., Florin, A., Büttner, R., Petrellis, G., Dewals, B. G., & Chariot, A. (2022). Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. EMBO Journal, 109353. doi:10.15252/embj.2021109353 https://hdl.handle.net/2268/294500

The most cited

70 citations (OpenAlex)

Gomes Da Silva, C., Peyre, E., Adhikari, M. H., Tielens, S., Tanco, S., Van Damme, P., Magno, L., Krusy, N., Agirman, G., Magiera, M. M., Kessaris, N., Malgrange, B., Andrieux, A., Janke, C., & Nguyen, L. (2018). Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Cell, 172 (5), 1063-1067.e19. doi:10.1016/j.cell.2018.01.031 https://hdl.handle.net/2268/223005

Oskera, L., Charlet-Briart, M., Tielens, S., Nguyen, L., & Laguesse, S. (02 January 2026). Impact of Prenatal Alcohol Exposure on Cerebral Cortex Development. Advances in Experimental Medicine and Biology, 1500, 143 - 181. doi:10.1007/978-3-032-12741-9_6
Peer Reviewed verified by ORBi

Reyskens, C., Boutsen, A., Nian, F.-S., Coumans, B., Krusy, N., Epifanova, E., Tielens, S.* , & Nguyen, L.*. (28 November 2025). Deciphering the role of EIF2S3 and TMEM167 during cerebral corticogenesis - in health and in disease- [Poster presentation]. GIGA- NEURO DAY.
* These authors have contributed equally to this work.

Charlet-Briart, M., Van Hees, L., Stoufflet, J., Oskera, L., Boutsen, A., Tielens, S., Laguesse, S., & Nguyen, L. (28 November 2025). NR2F1 is a Cross-Species Mediator of Cerebral Cortex Defects Induced by Fetal Alcohol Intoxication [Paper presentation]. GIGA NEURODAY, Liège, Belgium.
Editorial reviewed

Virgilio, E., Tielens, S., Bonfield, G., Nian, F.-S., Sawatani, T., Vinci, C., Govier, M., Montaser, H., Lartigue, R., Arunagiri, A., Liboz, A., Da Silva, F. N., Lytrivi, M., Papadopoulou, T., Wakeling, M. N., Russ-Silsby, J., Bowman, P., Johnson, M. B., Laver, T. W., ... De Franco, E. (17 November 2025). Recessive TMEM167A variants cause neonatal diabetes, microcephaly, and epilepsy syndrome. Journal of Clinical Investigation, 135 (22). doi:10.1172/JCI195756
Peer Reviewed verified by ORBi

Tilliole, P., Mattausch, C., Tilly, P., Leitão, E., Boutaud, L., Lehalle, D., An, I., Argilli, E., Aufox, S., Callewaert, B., Charles, P., Cinkornpumin, J. K., Courtin, T., Vecchia, M. D., Davis, E. E., Dimitrov, B. I., Dobyns, W., Epifanova, E., Grandgirard, E., ... Godin, J. D. (2025). RBMX functional retrocopy safeguards brain development. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/338904. doi:10.1101/2025.10.17.25337589

Tielens, S. (17 October 2025). Elongator controls the maturation tempo of brain ependymal cells [Paper presentation]. Brain malformation symposium, Antwerp, Belgium.
Editorial reviewed

Bonafina, A., Boutsen, A., Coumans, B., Tielens, S., Kune, C., Javier Torrent, M., Le Bail, R., Mazzucchelli, G., Carsten Janke, Cappello Silvia, Espuny Camacho, I. M., & Nguyen, L. (15 October 2025). CCP1 contributes to human cortical interneuron migration revealing species specific features [Poster presentation]. Microtubuli in Neurons 2025, Germany.
Editorial reviewed

Reyskens, C., Boutsen, A., Niam, F.-S., Coumans, B., Krusy, N., Epifanova, E., Tielens, S.* , & Nguyen, L.*. (12 September 2025). Deciphering the role of EIF2S3 and TMEM167 during cerebral corticogenesis - in health and in disease- [Poster presentation]. GIGA-DAY, Liège, Belgium.
* These authors have contributed equally to this work.

Charlet-Briart, M., Van Hees, L., Stoufflet, J., Oskera, L., Boutsen, A., Tielens, S., Laguesse, S., & Nguyen, L. (12 September 2025). DECIPHERING HOW PRENATAL ALCOHOL EXPOSURE IMPAIRS SOMATOSENSORY CORTEX DEVELOPMENT AT SINGLE CELL LEVEL [Paper presentation]. GIGA DAY, Liège, Belgium.

Tielens, S. (12 September 2025). Elongator controls the maturation tempo of brain ependymal cells [Paper presentation]. GIGAday.
Editorial reviewed

Charlet-Briart, M., Van Hees, L., Stoufflet, J., Oskera, L., Tielens, S., Laguesse, S., & Nguyen, L. (06 September 2025). DECIPHERING HOW PRENATAL ALCOHOL EXPOSURE IMPAIRS SOMATOSENSORY CORTEX DEVELOPMENT AT SINGLE CELL LEVEL [Paper presentation]. 20th ESBRA conference, Bruxelles, Belgium.
Editorial reviewed

Charlet-Briart, M., Van Hees, L., Stoufflet, J., Oskera, L., Tielens, S., Laguesse, S., & Nguyen, L. (21 June 2025). Deciphering how prenatal alcohol exposure impairs somatosensory cortex development at single cell level [Poster presentation]. 2025 Meeting RSA, New Orleans, United States.
Editorial reviewed

Kune, C., Tielens, S., Fleron, M., Baiwir, D., Berkal, M. A., Nguyen Laurent, Eppe, G., & Mazzucchelli, G. (17 June 2025). Smarter Libraries for Faster DIA: A Sequential Digestion Strategy to Enhance Proteome Coverage in DDA-based Spectral Libraries [Poster presentation]. European Proteomics Association (EuPA), Saint-Malo, France.

Kune, C., Gholizadeh, A., Tielens, S., Fleron, M., Baiwir, D., Vandormael, D., Nguyen, L., Eppe, G., Gilet, T., & Mazzucchelli, G. (17 June 2025). Boosting Proteomics at Single-Cell Level: Enhancing Peptide Recovery, Automation, Chromatographic Robustness and Performance [Paper presentation]. European Proteomics Association (EuPA) 2025, Saint Malo, France.
Peer reviewed

Tielens, S. (2025). Study of the embryonic basis of striatal neurodegeneration associated with NUP62 mutation [Paper presentation]. Conférence Lions Liège Airport, Belgium.

Kune, C., Tielens, S., Baiwir, D., Fleron, M., Vandormael, D., Eppe, G., Nguyen, L., & Mazzucchelli, G. (25 February 2025). SIGNIFICANT IMPACT OF CONSUMABLE MATERIAL AND BUFFER COMPOSITION FOR LOW-CELL NUMBER PROTEOMIC SAMPLE PREPARATION. Analytical Chemistry, 97 (7), 3836 - 3845. doi:10.1021/acs.analchem.4c03709
Peer Reviewed verified by ORBi

Tielens, S. (23 January 2025). Neuro-archeology: the developmental roots of juvenile striatal necrosis and its nuclear pore transport deficits [Paper presentation]. Biomedical Center (BMC), LMU, Munich, Germany.
Editorial reviewed

Tielens, S., Boutin, C., Huysseune, S., Thelen, N., Charlet-Briart, M., Reyskens, C., Oskera, L., Boutsen, A., Mateo-Sanchez, S., Delacroix, L., Labedan, P., Thiry, M., Malgrange, B., Chariot, A., Tissir, F., Creppe, C., Seuntjens, E., Laguesse, S., & Nguyen, L. (2025). Loss of Elp3 impairs the maturation tempo of brain ependymal cells. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/328565. doi:10.1101/2025.01.07.631730

Tielens, S. (2024). Study of the embryonic basis of striatal neurodegeneration associated with NUP62 mutation [Paper presentation]. Conférence Rotary Club Herstal, Belgium.

Boutsen, A., Bonafina, A., Coumans, B., Javier Torrent, M., Tielens, S., Kune, C., Mazzucchelli, G., & Nguyen, L. (15 October 2024). Deciphering how interneurons control cerebral cortical morphogenesis - from mouse to human assembloids - [Poster presentation]. EMBO Workshop : Unlocking human brain complexity using 3D culture and single-cell omics, Capri, Italy.
Editorial reviewed

Tielens, S.* , Boutin Camille* , Huysseune, S.* , Thelen, N., Charlet-Briart, M., Reyskens, C., Oskera, L., Boutsen, A., Mateo Sanchez, S., Delacroix, L., Labedan Paul, Thiry, M., Malgrange, B., Chariot, A., Tissir Fadel, Creppe, C., Seuntjens, E., Laguesse, S.* , & Nguyen, L.*. (23 September 2024). Elp3 controls the maturation tempo of brain ependymal cells via NOTCH signaling [Poster presentation]. 25th Biennial meeting of the International Society for Developmental Neuroscience, Montpellier, France.
Editorial reviewed
* These authors have contributed equally to this work.

Wathieu, C., Lavergne, A., Xu, X., Rolot, M., Nemazanyy, I., Shostak, K., El Hachem, N., Maurizy, C., Leemans, C., Close, P., Nguyen, L., Desmet, C., Tielens, S.* , Dewals, B. G.* , & Chariot, A.*. (2024). Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis. EMBO Journal. doi:10.1038/s44318-024-00184-4
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Tielens, S., Krusy, N., Stern, D., Van Hees, L., Reyskens, C., Laguesse, S., Chariot, A., & Nguyen, L. (28 September 2023). Unveiling the embryonic basis of neurodegeneration linked to impaired nucleocytoplasmic transport [Poster presentation]. Axon2023, Alicante, Spain.
Editorial reviewed

Bonafina, A., Boutsen, A., Coumans, B., Tielens, S., Close, R., Kune, C., Javier Torrent, M., Le Bail, R., Firquet, A., Mazzucchelli, G., Carsten, J., Cappello, S., Perrier d'Hauterive, S., Espuny Camacho, I. M., & Nguyen, L. (01 September 2023). Modeling cortical interneuron migration in brain assembloids from patients presenting CCP1 mutation [Poster presentation]. GIGA Day 2023.
Editorial reviewed

Stoufflet, J., Tielens, S., & Nguyen, L. (22 June 2023). Shaping the cerebral cortex by cellular crosstalk. Cell, 186 (13), 2733 - 2747. doi:10.1016/j.cell.2023.05.040
Peer Reviewed verified by ORBi

Turchetto, S., Tielens, S., Thiry, M., & Nguyen, L. (06 September 2022). Molecular mechanisms of long-distance transport: a new role for local translation? [Poster presentation]. GIGA Day, Liege, Belgium.

Tielens, S., Krusy, N., Stern, D., Van Hees, L., Turchetto, S., Maurizy, C., Stoufflet, J., Laguesse, S., Chariot, A., & Nguyen, L. (06 September 2022). Unveilling the embryonic basis of neurodegeneration linked to impaired nucleocytoplasmic transport [Poster presentation]. GIGA day, Liège, Belgium.

Chen, D., Nemazanyy, I., Peulen, O., Shostak, K., Xu, X., Tang, S. C., Wathieu, C., Turchetto, S., Tielens, S., Nguyen, L., Close, P., Desmet, C., Klein, S., Florin, A., Büttner, R., Petrellis, G., Dewals, B. G., & Chariot, A. (2022). Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. EMBO Journal, 109353. doi:10.15252/embj.2021109353
Peer Reviewed verified by ORBi

Turchetto, S., Tielens, S., Thiry, M., & Nguyen, L. (July 2022). Molecular mechanisms of long-distance transport: a new role for local translation? [Poster presentation]. RNA localization and local translation, Sant Feliu de Guixol, Spain.

Kune, C., Tielens, S., Fleron, M., Baiwir, D., Nguyen, L., Eppe, G., & Mazzucchelli, G. (07 June 2022). From Downscaling to Single-Cell Proteomic: Understanding and minimizing the downscaling effect [Poster presentation]. 70th American Society for Mass Spectrometry (ASMS) annual conference, Minneapolis, United States - Minnesota.
Peer reviewed

Wathieu, C., Tielens, S., Lavergne, A., Shostak, K., Rolot, M., El Hachem, N., Xu, X., Close, P., Nguyen, L., Desmet, C., Dewals, B. G., & CHARIOT, A. (10 May 2022). A role for the tRNA-modifying enzyme Elp3 in tuft cell differentiation and in the immune response in the intestine [Paper presentation]. Type 2 Immunity in Early Life Symposium, Liège, Belgium.

Thomson, A. C., Kenis, G., Tielens, S., De Graaf, T. A., Schuhmann, T., Rutten, B. P., & Sack, A. T. (2021). Transcranial Magnetic Stimulation-Induced Plasticity Mechanisms: TMS-Related Gene Expression and Morphology Changes in a Human Neuron-Like Cell Model. Frontiers in Molecular Neuroscience. doi:10.3389/fnmol.2020.528396
Peer Reviewed verified by ORBi

Shostak, K., Wathieu, C., Tielens, S., & Chariot, A. (2021). NF-κB Signaling in Ex-Vivo Mouse Intestinal Organoids. Methods in Molecular Biology, 2366, 283-292. doi:10.1007/978-1-0716-1669-7_17
Peer reviewed

Wathieu, C., Tielens, S., Rolot, M., Shostak, K., Close, P., Dewals, B. G., & CHARIOT, A. (16 October 2018). A role for the tRNA-modifying enzyme Elp3 in tuft cell differentiation and in the immune response in the intestine [Poster presentation]. EMBO workshop "From epigenome towards epitranscriptome in cell fate choice", Capri, Italy.

Laguesse, S., Huysseune, S., Boutin, C., Tielens, S., Franco, B., Mateo Sánchez, S., Delacroix, L., Boutin, P., Malgrange, B., CHARIOT, A., Goffinet, A., Tissir, F., Creppe, C., Seuntjens, E., & Nguyen, L. (13 June 2018). Loss of Elp3 induces postnatal hydrocephalus by inducing endoplasmic reticulum stress and dysregulation of Notch signaling [Poster presentation]. BSCDB spring meeting, Liege, Belgium.

Gomes Da Silva, C., Peyre, E., Adhikari, M. H., Tielens, S., Tanco, S., Van Damme, P., Magno, L., Krusy, N., Agirman, G., Magiera, M. M., Kessaris, N., Malgrange, B., Andrieux, A., Janke, C., & Nguyen, L. (2018). Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Cell, 172 (5), 1063-1067.e19. doi:10.1016/j.cell.2018.01.031
Peer Reviewed verified by ORBi

Tielens, S. (08 July 2016). Understanding the contribution of Elp3 in cortical interneuron migration [Paper presentation]. FHML montly meeting, Maastricht, Netherlands.

Tielens, S., Huysseune, S., Godin, J., CHARIOT, A., Malgrange, B., & Nguyen, L. (12 May 2016). Elongator controls cortical interneuron migration by regulating actomyosin dynamics [Poster presentation]. ISDN, France.

Tielens, S.* , Huysseune, S.* , Godin, J. D., Chariot, A., Malgrange, B., & Nguyen, L. (2016). Elongator controls cortical interneuron migration by regulating actomyosin dynamics. Cell Research. doi:10.1038/cr.2016.112
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Tielens, S., Godin, J. D., & Nguyen, L. (2016). Real-time Recordings of Migrating Cortical Neurons from GFP and Cre Recombinase Expressing Mice. Current Protocols in Neuroscience, 74, 3.29.1-23. doi:10.1002/0471142301.ns0329s74
Editorial reviewed

Tielens, S., Huysseune, S., Malgrange, B., CHARIOT, A., Godin, J., & Nguyen, L. (08 July 2014). Deciphering the role of Elp3 in interneuron migration in cortical development [Poster presentation]. FENS, Milano, Italy.

Avila, A., Vidal, P. M., Tielens, S., Morelli, G., Laguesse, S., Harvey, J. H., Rigo, J.-M., & Nguyen, L. (2014). Glycine receptors control the generation of projection neurons in the developing cerebral cortex. Cell Death and Differentiation, 21 (11), 1696-1708. doi:10.1038/cdd.2014.75
Peer Reviewed verified by ORBi

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