Profil

Laguesse Sophie

GIGA Neurosciences - Molecular Regulation of Neurogenesis

Département des sciences biomédicales et précliniques

See author's contact details
ORCID
0000-0002-9217-0087
Main Referenced Co-authors
Nguyen, Laurent  (40)
Chariot, Alain  (23)
Malgrange, Brigitte  (20)
Close, Pierre  (15)
Van Hees, Laura  (14)
Main Referenced Keywords
alcohol (9); mTORC1 (8); Alcohol (5); Animals (5); Cortex (5);
Main Referenced Unit & Research Centers
Giga Neurosciences - ULiège [BE] (14)
Department of Neurology, Alcohol Center for Translational Genetics, University of California San Francisco, CA 94143 (4)
Giga-Development and Stem Cells - ULiège [BE] (2)
UCSF - Neurology Unit - Ron lab (2)
Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, Rhode Island. (1)
Main Referenced Disciplines
Neurology (43)
Biochemistry, biophysics & molecular biology (13)
Life sciences: Multidisciplinary, general & others (10)
Anatomy (cytology, histology, embryology...) & physiology (3)
Human health sciences: Multidisciplinary, general & others (1)

Publications (total 66)

The most downloaded
778 downloads
creppe, C., malinouskaya, L., Volvert, M.-L., Close, P., Laguesse, S., Gillard, M., Chariot, A., & Nguyen, L. (2010). Elongator orchestrates cerebral cortical neurogenesis. MS. Medecine Sciences. doi:10.1051/medsci/2010262135 https://hdl.handle.net/2268/41002

The most cited

399 citations (Scopus®)

Creppe, C., Malinouskaya, L., Volvert, M.-L., Gillard, M., Close, P., Malaise, O., Laguesse, S., Cornez, I., Rahmouni, S., Ormenese, S., Belachew, S., Malgrange, B., Chapelle, J.-P., Siebenlist, U., Moonen, G., Chariot, A., & Nguyen, L. (06 February 2009). Elongator controls the migration and differentiation of cortical neurons through acetylation of a tubulin. Cell, 136, 551-564. doi:10.1016/j.cell.2008.11.043 https://hdl.handle.net/2268/5901

Laguesse, S. (16 October 2023). Unveiling the consequences of adolescent alcohol exposure on prefrontal cortex maturation [Paper presentation]. Mediterranean Society for Neurosciences Meeting 2023, Tunis, Tunisia.
Peer reviewed

Tielens, S., Krusy, N., Stern, D., Van Hees, L., Reyskens, C., Laguesse, S., Chariot, A., & Nguyen, L. (28 September 2023). Unveiling the embryonic basis of neurodegeneration linked to impaired nucleocytoplasmic transport [Poster presentation]. Axon2023, Alicante, Spain.

Charlet-Briart, M., Oskera, L., Laguesse, S., & Nguyen, L. (04 September 2023). Alcohol binge-drinking during adolescence impairs behaviors in adulthood by modulating mTORC1 activity in the prefrontal cortex [Poster presentation]. GIGA Day, Liège, Belgium.

Charlet-Briart, M., Oskera, L., Nguyen, L., & Laguesse, S. (03 September 2023). Alcohol binge-drinking during adolescence impairs behaviors in adulthood by modulating mTORC1 activity in the prefrontal cortex [Poster presentation]. ESBRA 2023, Graz, Austria.

Laguesse, S., Van Hees, L., Stoufflet, J., Charlet-Briart, M., Boutsen, A., & Nguyen, L. (01 September 2023). Prenatal alcohol exposure impairs mouse somatosensory cortex development by delaying projection neurons migration [Paper presentation]. European Society for Biomedical Research on Alcoholism meeting, Graz, Austria.
Peer reviewed

Laguesse, S., Van Hees, L., Charlet-Briart, M., & Nguyen, L. (16 May 2023). Unveiling the consequences of adolescent alcohol exposure on prefrontal cortex maturation [Paper presentation]. Alcohol & Stress conference Volterra 2023.
Peer reviewed

Burniat, A., Noël, A., Colige, A., Vanderplasschen, A., de Kerchove d'Exaerde, A., Kupper Cardozo, A., Van Keymeulen, A., Moens, A., Bondue, A., Herpain, A., Marchant, A., Loumaye, A., Beck, B., Van den Heyden, B., Corvilain, B., Lakaye, B., Rogister, B., Malgrange, B., Michiels, C., ... Brunko, E. (2023). Cent scientifiques répliquent à SEA (Suppression des Expériences sur l’Animal vivant) et dénoncent sa désinformation. La Libre Belgique.

Laguesse, S., Van Hees, L., Stoufflet, J., Charlet-Briart, M., Boutsen, A., & Nguyen, L. (12 September 2022). Prenatal alcohol exposure impairs mouse somatosensory cortex development by delaying projection neurons migration [Paper presentation]. European Fetal Alcohol Spectrum Disorders Conference, Arendal, Norway.
Editorial reviewed

Tielens, S., Krusy, N., Stern, D., Van Hees, L., Turchetto, S., Maurizy, C., Stoufflet, J., Laguesse, S., Chariot, A., & Nguyen, L. (06 September 2022). Unveilling the embryonic basis of neurodegeneration linked to impaired nucleocytoplasmic transport [Poster presentation]. GIGA day, Liège, Belgium.

Van Hees, L., Didone, V., Charlet-Briart, M., Van Ingelgom, T., Alexandre, A., Quertemont, E., Nguyen, L.* , & Laguesse, S.*. (2022). Voluntary alcohol binge-drinking in adolescent C57Bl6 mice induces delayed appearance of behavioural defects in both males and females. Addiction Biology. doi:10.1111/adb.13102
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Even, A.* , Morelli, G.* , Turchetto, S.* , Shilian, M., Le Bail, R., Laguesse, S., Krusy, N., Brisker, A., Brandis, A., Inbar, S., Chariot, A., Saudou, F., Dietrich, P., Dragatsis, I., Brone, B., Broix, L., Rigo, J.-M., Weil, M., & Nguyen, L. (2021). ATP-citrate lyase promotes axonal transport across species. Nature Communications, 12 (1), 5878. doi:10.1038/s41467-021-25786-y
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Ehinger, Y., Phamluong, K., Darvesky, D., Welman, M., Moffat, J., Sakhai, S., Whiteley, E., Berger, A., Laguesse, S., Farokhnia, M., Leggio, L., Lordkipanidze, M., & Ron, D. (2020). Differential Correlation of Serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use. Addiction Biology. doi:10.1111/adb.12890
Peer Reviewed verified by ORBi

Laguesse, S., & Ron, D. (February 2020). Protein translation and psychiatric disorders. Neuroscientist, 26 (1), 21-42. doi:10.1177/1073858419853236
Peer Reviewed verified by ORBi

Laguesse, S. (22 September 2019). Unveiling the alcohol-dependent alterations in prefrontal cortex maturation and behaviors [Paper presentation]. European Society for Biomedical Research on Alcoholism, Lille, France.

Laguesse, S., VAN HEES, L., & Nguyen, L. (22 September 2019). Unveiling the alcohol-dependent alterations of local translation in the prefrontal cortex during adolescence [Paper presentation]. ESBRA meeting 2019.
Peer reviewed

Van Hees, L., Laguesse, S., & Nguyen, L. (21 September 2019). Unveiling the neurogenesis defects induced by prenatal alcohol exposure [Poster presentation]. 17th ESBRA Congress, Lille, France.

Van Hees, L., Nguyen, L., & Laguesse, S. (September 2019). Unveiling the alcohol-dependent alterations of local translation in the prefrontal cortex during adolescence [Poster presentation]. European Society for Biomedical Research in Alcoholism 2019 Meeting, Lille, France.

Van Hees, L., Laguesse, S., & Nguyen, L. (13 June 2019). Unveiling the neurogenesis defects induced by prenatal alcohol exposure [Poster presentation]. Experimental models for human diseases, Liège, Belgium.

Freeman, S.* , Mateo Sánchez, S.* , Pouyo, R., Van Lerberghe, P.-B., Hanon, K., Thelen, N., Thiry, M., Morelli, G., Van Hees, L., Laguesse, S., Chariot, A., Nguyen, L., Delacroix, L.* , & Malgrange, B.*. (2019). Proteostasis is essential during cochlear development for neuron survival and hair cell polarity. EMBO Reports, 20 (9). doi:10.15252/embr.201847097
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Van Hees, L., Laguesse, S., & Nguyen, L. (19 October 2018). Unveiling the neurogenesis defects induced by prenatal alcohol exposure [Poster presentation]. Belgian Brain Congress 2018, Liège, Belgium.

Laguesse, S., Sakhai, S., Phamluong, K., & Morisot, N. (13 September 2018). mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption [Poster presentation]. ISBRA, Kyoto, Japan.

Laguesse, S., Huysseune, S., Boutin, C., Tielens, S., Franco, B., Mateo Sánchez, S., Delacroix, L., Boutin, P., Malgrange, B., CHARIOT, A., Goffinet, A., Tissir, F., Creppe, C., Seuntjens, E., & Nguyen, L. (13 June 2018). Loss of Elp3 induces postnatal hydrocephalus by inducing endoplasmic reticulum stress and dysregulation of Notch signaling [Poster presentation]. BSCDB spring meeting, Liege, Belgium.

Van Hees, L., Laguesse, S., & Nguyen, L. (08 June 2018). Unveiling the neurogenesis defects induced by prenatal alcohol exposure [Poster presentation]. Spring meeting of the BSCDB, Liège, Belgium.

Laguesse, S., Morisot, N., Phamluong, K., Sakhai, S. A., & Ron, D. (2018). mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption. Neuropsychopharmacology, 1-9. doi:10.1038/s41386-018-0012-1
Peer Reviewed verified by ORBi

Ben Hamida, S., Laguesse, S., Morisot, N., Park, J.-H., Phuamluong, K., Berger, A. L., Park, K. D., & Ron, D. (2018). Mammalian target of rapamycin complex 1 and its downstream effector collapsin response mediator protein-2 drive reinstatement of alcohol reward seeking. Addiction Biology. doi:10.1111/adb.12653
Peer Reviewed verified by ORBi

Laguesse, S., Morisot, N., Shin, J. H., Liu, F., Adrover, M. F., Sakhai, S. A., Lopez, M., Phamluong, K., Griffin, W. C., Becker, H. C., Bender, K. J., Alvarez, V. A., & Ron, D. (September 2017). Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Neuron, 96 (1), 145-159.e8. doi:10.1016/j.neuron.2017.08.037
Peer Reviewed verified by ORBi

Liu, F., Laguesse, S., Legastelois, R., Morisot, N., Ben Hamida, S., & Ron, D. (2017). MTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors. Molecular Psychiatry, 22 (1), 89-101. doi:10.1038/mp.2016.12
Peer Reviewed verified by ORBi

Laguesse, S., Morisot, N., Phamluong, K., & Ron, D. (2017). Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents. Addiction Biology, 22 (6), 1856-1869. doi:10.1111/adb.12464
Peer Reviewed verified by ORBi

Laguesse, S., Close, P., Van Hees, L., Chariot, A., Malgrange, B., & Nguyen, L. (2017). Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex. Frontiers in Cellular Neuroscience, 11, 122. doi:10.3389/fncel.2017.00122
Peer Reviewed verified by ORBi

Laguesse, S. (12 November 2016). Prosapip1- a novel mediator of alcohol abuse disorder [Paper presentation]. Society for Neurosciences meeting 2016, San Diego, United States.

Laguesse, S. (November 2016). Prosapip1- a novel mediator of alcohol abuse disorder [Paper presentation]. Society for Neurosciences 2016, San Diego, United States.
Editorial reviewed

Laguesse, S. (13 October 2016). Prosapip1, a new target for alcohol [Paper presentation]. Belgian Society for Cell and Developmental Biology, Ghent, Belgium.

Laguesse, S. (13 October 2016). Prosapip1-a novel target for alcohol [Paper presentation]. Belgian Society for Cell and Developmental Biology (BSCDB) Autumn meeting 2016, Gent, Belgium.
Editorial reviewed

Laguesse, S. (October 2016). Prosapip1- A Novel Mediator of Alcohol Abuse Disorder [Poster presentation]. Society for neurosciences, San Diego, United States.

Laguesse, S., morisot, N., sakhai, S., & ron, D. (09 February 2016). Prosapip1-a novel target of alcohol drinking behaviors [Paper presentation]. Gordon Conference Alcohol & the nervous system, Galveston, United States.

Laguesse, S. (07 February 2016). Prosapip-1 a novel mediateor of alcohol use disorders [Paper presentation]. Gordon Research Conference Alcohol & the nervous system.
Peer reviewed

Beckley, J. T., Laguesse, S., Phamluong, K., Morisot, N., Wegner, S. A., & Ron, D. (2016). The first alcohol drink triggers mTORC1-dependent synaptic plasticity in nucleus accumbens dopamine D1 receptor neurons. Journal of Neuroscience, 36 (3), 701-713. doi:10.1523/JNEUROSCI.2254-15.2016
Peer Reviewed verified by ORBi

Laguesse, S., Creppe, C., Godin, J., & Nguyen, L. (2016). Implication de la réponse au stress du réticulum endoplasmique dans le contrôle de la neurogenèse corticale. MS. Medecine Sciences, 32 (6-7), 568-571. doi:10.1051/medsci/20163206014

Godin, J., Creppe, C., Laguesse, S., & Nguyen, L. (2016). Emerging Roles for the Unfolded Protein Response in the Developing Nervous System. Trends in Neurosciences, 39 (6), 394-404. doi:10.1016/j.tins.2016.04.002
Peer Reviewed verified by ORBi

Laguesse, S. (19 October 2015). Excessive alcohol drinking in rodents induces increased mTORC1-dependent Prosapip1 translation in the nucleus accumbens [Poster presentation]. SOciety for Neurosciences, Chicago, United States.

Laguesse, S.* , Creppe, C.* , Nedialkova, D., Prevot, P.-P., Borgs, L., Huysseune, S., Franco, B., Duysens, G., Krusy, N., Lee, G., Thelen, N., Thiry, M., Close, P., Chariot, A., Malgrange, B., Leidel, S., Godin, J., & Nguyen, L. (2015). A dynamic unfolded protein response contributes to the control of cortical neurogenesis. Developmental Cell, 35, 553-567. doi:10.1016/j.devcel.2015.11.005
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Laguesse, S. (24 October 2014). Elongator controls fate specification of progenitors during cerebral cortex development [Paper presentation]. Interuniversity attraction pole meeting 2014, Leuven, Belgium.
Editorial reviewed

Laguesse, S., Peyre, E., & Nguyen, L. (2014). Progenitor genealogy in the developing cerebral cortex. Cell and Tissue Research. doi:10.1007/s00441-014-1979-5
Peer Reviewed verified by ORBi

Laguesse, S. (May 2014). Loss of Elongator leads to microcephaly in mice [Poster presentation]. GIGA-Day meeting, Liege, Belgium.

Volvert, M.-L., Prevot, P.-P., Close, P., Laguesse, S., Pirotte, S., Hemphill, J., Rogister, F., Krusy, N., SACHELI, R., MOONEN, G., Deiters, A., Merkenschlager, M., CHARIOT, A., Malgrange, B., Godin, J., & Nguyen, L. (May 2014). MicroRNA Targeting of CoREST controls polarization of migrating cortical neurons. Cell Reports, 7 (4), 1168-83. doi:10.1016/j.celrep.2014.03.075
Peer Reviewed verified by ORBi

Avila, A., Vidal, P. M., Tielens, S., Morelli, G., Laguesse, S., Harvey, J. H., Rigo, J.-M., & Nguyen, L. (2014). Glycine receptors control the generation of projection neurons in the developing cerebral cortex. Cell Death and Differentiation, 21 (11), 1696-1708. doi:10.1038/cdd.2014.75
Peer Reviewed verified by ORBi

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (June 2013). p27(Kip1) as a master regulator of cortical neuron migration [Paper presentation]. EMBO fellow meeting.

Laguesse, S. (June 2013). Loss of ELongator leads to microcephaly in mice [Poster presentation]. BSCDB meeting, Liege, Belgium.

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (31 May 2013). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. BSN Congress.

Laguesse, S. (05 May 2013). Loss of ELongator leads to microcephaly in mice [Poster presentation]. GIGA-Day meeting, Liege, Belgium.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., MOONEN, G., Malgrange, B., Chariot, A., Métin, C., Besson, A., & Nguyen, L. (March 2013). p27(Kip1) as a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration [Paper presentation]. Microtubule cytoskeleton in development and disease conference.

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (28 January 2013). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. GIGA-DAY.

Huysseune, S., Boutin, C., Laguesse, S., Godin, J., Mateo Sanchez, S., & Nguyen, L. (2013). Unravelling the Roles of Elp3 in Ciliogenesis and Planar Polarity Establishment [Poster presentation]. Annual meeting of the belgium society of cell and developmental biology.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2013). p27(Kip1) as a master regulator of cortical neuron migration [Poster presentation]. annual meeting of the american society for cell biology.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2013). p27 Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration [Poster presentation]. annual meeting of the belgium society for neuroscience.

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (04 May 2012). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. GIGA-DAY.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2012). p27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration [Poster presentation]. Federation of European Neuroscience Societies (FENS).

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2012). p27(Kip1) as a master regulator of cortical neuron migration [Poster presentation]. EMBO Workshop on Cortical interneurons in health and disease.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2012). p27(Kip1) as a master regulator of cortical neuron migration [Poster presentation]. EMBO Conference Series Microtubules Structure, Regulation and Functions.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2012). Cortical interneurons tangential migration : p27(Kip1) as a novel master regulator [Poster presentation]. Cortical development conference.

Godin, J.* , Thomas, N.* , Laguesse, S.* , Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Chariot, A., Metin, C., Besson, A., & Nguyen, L. (2012). p27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration. Developmental Cell, 23 (4), 729-44. doi:10.1016/j.devcel.2012.08.006
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Laguesse, S. (October 2011). Unraveling the functions of ELongator in cerebral cortical neurogenesis [Poster presentation]. Wiring the brain: making connections, Dublin, Ireland.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (June 2011). p27(Kip1) as a master regulator of cortical neuron migration [Paper presentation]. cancéropole - Toulouse - France.

Laguesse, S. (2011). Connexin-43 as a potential target of Elp3 [Poster presentation]. 9th Belgian Society for Neurosciences meeting, Leuven, Belgium.

creppe, C., malinouskaya, L., Volvert, M.-L., Close, P., Laguesse, S., Gillard, M., Chariot, A., & Nguyen, L. (2010). Elongator orchestrates cerebral cortical neurogenesis. MS. Medecine Sciences. doi:10.1051/medsci/2010262135

Creppe, C., Malinouskaya, L., Volvert, M.-L., Gillard, M., Close, P., Malaise, O., Laguesse, S., Cornez, I., Rahmouni, S., Ormenese, S., Belachew, S., Malgrange, B., Chapelle, J.-P., Siebenlist, U., Moonen, G., Chariot, A., & Nguyen, L. (06 February 2009). Elongator controls the migration and differentiation of cortical neurons through acetylation of a tubulin. Cell, 136, 551-564. doi:10.1016/j.cell.2008.11.043
Peer Reviewed verified by ORBi

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