Profil

Laurent Clémentine

Main Referenced Co-authors
Galleni, Moreno  (24)
Hanikenne, Marc  (17)
Lekeux, Gilles  (13)
Damblon, Christian  (10)
Sohier, Jean  (7)
Main Referenced Keywords
inhibition (3); metallo-beta-lactamase (3); plant (2); Antibiotic resistance (1); beta-lactamase (1);
Main Referenced Unit & Research Centers
CIP - Centre d'Ingénierie des Protéines - ULiège [BE] (2)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (25)
Microbiology (1)
Phytobiology (plant sciences, forestry, mycology...) (1)

Publications (total 27)

The most downloaded
505 downloads
Sohier, J., Laurent, C., Chevigné, A., Pardon, E., Srinivasan, V., Wernery, U., Lassaux, P., Steyaert, J., & Galleni, M. (15 March 2013). Allosteric inhibition of VIM metallo-beta-lactamase by a camelid nanobody. Biochemical Journal, 450 (3), 477-486. doi:10.1042/BJ20121305 https://hdl.handle.net/2268/149489

The most cited

54 citations (Scopus®)

Lassaux, P., Traoré, D., Loisel, E., Favier, A., Docquier, J.-D., Sohier, J., Laurent, C., Bebrone, C., Frère, J.-M., Ferrer, J.-L., & Galleni, M. (2011). Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.01486-09 https://hdl.handle.net/2268/177221

Lekeux, G., Laurent, C., Joris, M., Jadoul, A., Jiang, D., Bosman, B., Carnol, M., Motte, P., Xiao, Z., Galleni, M., & Hanikenne, M. (2018). di-Cysteine motifs in the C-terminus of plant HMA4 proteins confer nanomolar affinity for zinc and are essential for HMA4 function in vivo. Journal of Experimental Botany, 69 (22), 5547-5560. doi:10.1093/jxb/ery311
Peer Reviewed verified by ORBi

Lekeux, G., Laurent, C., Xiao, Z., Crowet, J.-M., Lins, L., Hanikenne, M., & Galleni, M. (24 July 2017). Functional and structural characterisation of the Arabidopsis thaliana HMA4 protein [Poster presentation]. Cell Biology of Metals - Godon Research Conference, West Dover, United States.

Laurent, C. (2016). Caractérisation des motifs structuraux modulant l’affinité du transporteur HMA4 de Arabidopsis halleri pour les métaux [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/191891

Laurent, C.* , Lekeux, G.* , Ukuwela, A. A., Xiao, Z., Charlier, J.-B., Bosman, B., Carnol, M., Motte, P., Damblon, C., Galleni, M., & Hanikenne, M. (2016). Metal binding to the N-terminal cytoplasmic domain of the PIB ATPase HMA4 is required for metal transport in Arabidopsis. Plant Molecular Biology, 90, 453-466. doi:10.1007/s11103-016-0429-z
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Lekeux, G., Laurent, C., Hanikenne, M., & Galleni, M. (03 December 2015). Functional and structural characterization of the Arabidopsis thaliana HMA4 protein [Poster presentation]. IAP 7/44 Meeting - Integrative Protein Science: from small molecules to complex biological systems – iPros, Leuven, Belgium.

Laurent, C., Lekeux, G., Damblon, C., Hanikenne, M., & Galleni, M. (08 June 2015). Functional and structural characterization of the Arabidopsis halleri HMA4 N-terminal domain [Poster presentation]. IAP meeting.

Lekeux, G., Laurent, C., Galleni, M., & Hanikenne, M. (08 June 2015). Functional and structural analysis of the Arabidopsis thaliana HMA4 protein [Poster presentation]. AIP meeting 2015.

Lekeux, G., Laurent, C., Damblon, C., Hanikenne, M., & Galleni, M. (14 November 2014). Structural and functional characterization of the Arabidopsis halleri HMA4 protein [Poster presentation]. Journée doctorale Namur "Industrial researches in structural biological chemistry".

Lekeux, G., Laurent, C., Damblon, C., Galleni, M., & Hanikenne, M. (09 September 2014). Structural and functional analysis of the HMA4 protein [Poster presentation]. Summer school-Chemistry of metals in biological systems.

Lekeux, G., Laurent, C., Damblon, C., Hanikenne, M., & Galleni, M. (15 May 2014). Structural and functional analysis of the Arabidopsis halleri HMA4 protein [Poster presentation]. Bioforum 2014.

Lekeux, G., Laurent, C., Damblon, C., Galleni, M., & Hanikenne, M. (06 May 2014). Structural and functional study of the Arabidopsis halleri HMA4 protein [Poster presentation]. PhytoSYSTEMS day.

Lekeux, G., Laurent, C., Damblon, C., Hanikenne, M., & Galleni, M. (15 November 2013). Structural and functional analysis of the Arabidopsis halleri HMA4 N-terminal domain [Poster presentation]. SFMBBM Doctoral School.

Lekeux, G., Laurent, C., Damblon, C., Hanikenne, M., & Galleni, M. (18 April 2013). Structural and functional study of the Arabidopsis halleri HMA4 N-terminal domain [Poster presentation]. Bioforum 2013, Liège, Belgium.

Sohier, J., Laurent, C., Chevigné, A., Pardon, E., Srinivasan, V., Wernery, U., Lassaux, P., Steyaert, J., & Galleni, M. (15 March 2013). Allosteric inhibition of VIM metallo-beta-lactamase by a camelid nanobody. Biochemical Journal, 450 (3), 477-486. doi:10.1042/BJ20121305
Peer Reviewed verified by ORBi

Lekeux, G., Laurent, C., Damblon, C., Hanikenne, M., & Galleni, M. (26 February 2013). Structural and functional characterization of the Arabidopsis halleri HMA4 N-terminal domain [Poster presentation]. IAP meeting: "Integrative Protein Science: from small molecules to complex biological systems".

Laurent, C., Damblon, C., Hanikenne, M., & Galleni, M. (November 2012). Study of the structural factors that modulate the metal binding affinity of the N-terminal domain of the Arabidospsis halleri HMA4 [Poster presentation]. YBMRS 2012, Spa, Belgium.

Laurent, C., Hanikenne, M., & Galleni, M. (September 2012). Study of the structural factors that modulate the metal binding affinity of the Arabidopsis halleri HMA4 [Poster presentation]. Sofia School of Protein Science :Structure and dynamics of biological macromolecules, Sofia, Bulgaria.

Laurent, C. (18 April 2012). Characterisation of metal binding affinities of HMA4 from Arabidopsis halleri [Poster presentation]. Biomedica 2012, Liège, Belgium.

Sohier, J., Laurent, C., Chevigné, A., Pardon, E., Srinivasan, V., Lassaux, P., Buys, N., Willibal, K., Steyaert, J., & Galleni, M. (2012). Allosteric inhibition of VIMs metallo-β-lactamases by a camelid single-domain antibody fragment [Poster presentation]. Biomedica 2012.

Laurent, C., Sohier, J., Pardon, E., Lassaux, P., Buys, N., Willibal, K., Steyaert, J., Wyns, L., & Galleni, M. (10 December 2011). Characterization of the inhibition of metallo-β-lactamases of subclass B1 by VHHs cAbVIM4 and cAbBCII10 [Poster presentation]. journée doctorale SFMBBM, Liège, Belgium.

Laurent, C. (14 October 2011). Insight into the structural factors that modulate the metal binding affinity of the Arabidospsis halleri HMA4 [Paper presentation]. Journée doctorale SFMBBM, Bruxelles, Belgium.

Laurent, C., Hanikenne, M., & Galleni, M. (14 October 2011). Insight into the structural factors that modulate the metal binding affinity of the Arabidospsis halleri HMA4 [Paper presentation]. SFMBBM graduate school 5th annual meeting, bruxelles, Belgium.

Laurent, C., Hanikenne, M., & Galleni, M. (14 October 2011). Insight into the structural factors that modulate the metal binding affinity of the Arabidospsis halleri HMA4 [Poster presentation]. SFMBBM graduate school 5th annual meeting, Bruxelles, Belgium.

Lassaux, P., Traoré, D., Loisel, E., Favier, A., Docquier, J.-D., Sohier, J., Laurent, C., Bebrone, C., Frère, J.-M., Ferrer, J.-L., & Galleni, M. (2011). Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.01486-09
Peer Reviewed verified by ORBi

Sohier, J., Laurent, C., Pardon, E., Lassaux, P., Buys, N., Willibal, K., Steyaert, J., Wyns, L., & Galleni, M. (2010). cAbVIM4, a nanobody inhibiting the metallo-β-lactamase VIM-4 [Poster presentation]. 35th FEBS Congress: Molecules of Life, Göteborg, Sweden.

Sohier, J., Laurent, C., Chevigné, A., Pardon, E., Srinvasan, V., Lassaux, P., Buys, N., Willibal, K., Steyaert, J., & Galleni, M. (2010). Characterisation of B1 metallo-beta-lactamase inhibition by VHHs.

Sohier, J., Laurent, C., Pardon, E., Srinivasan, V., Lassaux, P., Buys, N., Willibal, K., Steyaert, J., & Galleni, M. (2010). CA1838, A NANOBODY INHIBITING THE METALLO-β-LACTAMASE VIM-4 [Poster presentation]. Single Domain Antibodies Come of Age.

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