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Krier Fabrice

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Main Referenced Co-authors
Evrard, Brigitte  (44)
Pestieau, Aude  (18)
Hubert, Philippe  (17)
Thiry, Justine  (16)
Ziemons, Eric  (16)
Main Referenced Keywords
Hot melt extrusion (3); implant (3); Process Analytical Technology (3); Sulindac (3); biomaterial (2);
Main Referenced Unit & Research Centers
Centre Interfacultaire de Recherche du Médicament - CIRM (27)
Center for Education and Research on Macromolecules (CERM) (4)
C.I.R.M. (3)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (42)
Materials science & engineering (2)
Chemistry (2)
Reproductive medicine (gynecology, andrology, obstetrics) (1)

Publications (total 45)

The most downloaded
283 downloads
Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Ziemons, E., Evrard, B., & Hubert, P. (15 November 2010). Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities [Poster presentation]. The FIP Pharmaceutical Sciences World Congress 2010 in association with the AAPS Annual Meeting & Exposition, new orléans, United States. https://hdl.handle.net/2268/78209

The most cited

471 citations (OpenAlex)

Thoorens, G., Krier, F., Leclercq, B., Carlin, B., & Evrard, B. (01 October 2014). Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review. International Journal of Pharmaceutics, 473 (1-2), 64-72. doi:10.1016/j.ijpharm.2014.06.055 https://hdl.handle.net/2268/170759

Thiry, J., Broze, G., Pestieau, A., Tatton, A., Baumans, F., Damblon, C., Krier, F., & Evrard, B. (2016). Investigation of a suitable in vitro dissolution test for itraconazole-based solid dispersions. European Journal of Pharmaceutical Sciences. doi:10.1016/j.ejps.2016.02.002
Peer Reviewed verified by ORBi

Thiry, J., Lebrun, P., Netchacovitch, L., Pestieau, A., Ziemons, E., Hubert, P., Krier, F., & Evrard, B. (October 2015). Production of Itraconazole/Soluplus® Extrudates: Optimization of Both Formulation and Hot-Melt Extrusion Process Through a Single Design of Experiment [Poster presentation]. AAPS Orlando 2015.

Netchacovitch, L., Thiry, J., De Bleye, C., Chavez, P.-F., Krier, F., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (September 2015). Vibrational spectroscopy and microspectroscopy analyzing qualitatively and quantitatively pharmaceutical hot melt extrudates. Journal of Pharmaceutical and Biomedical Analysis, 113, 21-33. doi:10.1016/j.jpba.2015.01.051
Peer Reviewed verified by ORBi

Pestieau, A., Krier, F., Lebrun, P., & Evrard, B. (29 May 2015). Optimization of a PGSS process for a fenofibrate lipid-based solid dispersion formulation [Paper presentation]. 18th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Netchacovitch, L., Thiry, J., De Bleye, C., Chavez, P.-F., Krier, F., Sacre, P.-Y., Evrard, B., Hubert, P., & Ziemons, E. (21 May 2015). Analysis of film casting by Raman confocal microscopy: An innovative approach in the framework of drug content and API solid-state determination [Paper presentation]. Forum des jeunes chercheurs, Namur, Belgium.

Thiry, J., Pestieau, A., Krier, F., & Evrard, B. (May 2015). How to choose a suitable dissolution test for BCS II drugs? [Paper presentation]. 18e Forum des Sciences Pharmaceutiques.

Pestieau, A., Krier, F., Lebrun, P., Brouwers, A., Streel, B., & Evrard, B. (18 March 2015). Optimization of a PGSS (particles from gas saturated solutions) process for a fenofibrate lipid-based solid dispersion formulation. International Journal of Pharmaceutics, 485, 295-305. doi:10.1016/j.ijpharm.2015.03.027
Peer Reviewed verified by ORBi

Thiry, J., Krier, F., & Evrard, B. (01 February 2015). A Review of Pharmaceutical Extrusion: Critical Process Parameters and Scaling-up. International Journal of Pharmaceutics, 479 (1), 227-240. doi:10.1016/j.ijpharm.2014.12.036
Peer Reviewed verified by ORBi

Thiry, J., Netchacovitch, L., Krier, F., Ziemons, E., Hubert, P., & Evrard, B. (2015). Determination of the Crystal Content within an Itraconazole-based extrudate : Comparison between Differential Scanning Calorimetry and Raman techniques [Poster presentation]. TA Instruments' BeNeLux Users Meeting & Symposium 2015.

Netchacovitch, L., Thiry, J., De Bleye, C., Chavez, P.-F., Sacre, P.-Y., Krier, F., Evrard, B., Hubert, P., & Ziemons, E. (January 2015). Confocal Raman microscopy to support the development of an extrusion process: a quantitative approach based on film casting [Poster presentation]. CHimiometrie XVI, Genève, Switzerland.

Pestieau, A., Krier, F., & Evrard, B. (12 December 2014). Optimization of a PGSS manufacturing process of a lipid-based solid dispersion containing a BCS II API [Paper presentation]. Meeting of the Belgian-Dutch Biopharmaceutical Society, Vlaardingen, Netherlands.

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (December 2014). Selection of a Discriminant Dissolution Test for Extrudates Containing Itraconazole [Poster presentation]. Biopharmacy Day 2014, Vlaardingen, Netherlands.

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (06 November 2014). Preformulation Study of an Itraconazole-based Oral Dosage Produced by Hot-Melt Extrusion [Poster presentation]. AAPS Annual Meeting San Diego 2014.

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (03 November 2014). Selection of a Discriminant Dissolution Test for Itraconazole-based Extrudates [Poster presentation]. AAPS Annual Meeting San Diego 2014.

Pestieau, A., Krier, F., Lebrun, P., & Evrard, B. (November 2014). Optimization of a PGSS manufacturing process of a lipid based solid dispersion of a BCS II API [Poster presentation]. 2014 AAPS Annual Meeting and Exposition, San Diego, United States.

Thoorens, G., Krier, F., Leclercq, B., Carlin, B., & Evrard, B. (01 October 2014). Microcrystalline cellulose, a direct compression binder in a quality by design environment—A review. International Journal of Pharmaceutics, 473 (1-2), 64-72. doi:10.1016/j.ijpharm.2014.06.055
Peer Reviewed verified by ORBi

Netchacovitch, L., Thiry, J., De Bleye, C., Sacre, P.-Y., Chavez, P.-F., Krier, F., Evrard, B., Hubert, P., & Ziemons, E. (June 2014). Confocal Raman microscopy to support the development of an extrusion process by qualitative and quantitative analyses [Poster presentation]. Drug Analysis 2014.

Pestieau, A., Krier, F., Thoorens, G., Dupont, A., Chavez, P.-F., Ziemons, E., Hubert, P., & Evrard, B. (June 2014). Towards a real time release approach for manufacturing tablets using NIR spectroscopy [Poster presentation]. Drug Analysis 2014, Liège, Belgium.

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (May 2014). Production of Itraconazole-based Solid Dispersions Using Hot-Melt Extrusion [Poster presentation]. AFPM 2014, Liège, Belgium.

Pestieau, A., Krier, F., Thoorens, G., Dupont, A., Chavez, P.-F., Ziemons, E., Hubert, P., & Evrard, B. (May 2014). Towards a real time release approach for manufacturing tablets using NIR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, 98, 60-67. doi:10.1016/j.jpba.2014.05.002
Peer Reviewed verified by ORBi

Krier, F. (2014). Développement et mise au point d'une méthode de production d'un implant intra-péritonéal destiné au traitement de l'endométriose [Doctoral thesis, Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/315235

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (2014). Production Of Itraconazole-based Solid Dispersions Using Hot-Melt Extrusion: Preformulation Study [Poster presentation]. 9th PBP World Meeting Lisbon 2014.

Krier, F., Riva, R., Defrère, S., Mestdagt, M., Van Langendonckt, A., Drion, P., Dehoux, J.-P., Donnez, J., Foidart, J.-M., Jérôme, C., & Evrard, B. (2014). Device-based controlled local delivery of anastrozol into peritoneal cavity: in vitro and in vivo evaluation. Journal of Drug Delivery Science and Technology, 24 (2), 198-204. doi:10.1016/S1773-2247(14)50032-9
Peer Reviewed verified by ORBi

Frère, A., Krier, F., Evrard, B., Mottet, D., & Piel, G. (2014). Polyplex Based On Polycarbonate Polymers For An Efficient Delivery Of An Anti-Angiogenic siRNA [Poster presentation]. 2014 AAPS Annual Meeting and Exposition, San Diego, United States.

Pestieau, A., Krier, F., Thoorens, G., Dupont, A., Chavez, P.-F., Ziemons, E., Hubert, P., & Evrard, B. (November 2013). Real time release approach in terms of four Pharmacopoeia tests for tablets manufacturing using NIR spectroscopy [Poster presentation]. AAPS Annual Meeting and Exposition, San Antonio, United States.

Chavez, P.-F., Netchacovitch, L., Sacre, P.-Y., De Bleye, C., Pestieau, A., Krier, F., Mantanus, J., Motte, H., Schubert, M., Evrard, B., Hubert, P., & Ziemons, E. (June 2013). Optimization of a Pharmaceutical Tablet Formulation: Screening Experiments using Vibrational Spectroscopy as PAT Tool [Poster presentation]. 2013 AAPS Annual Meeting and Exposition, San Antonio, United States - Texas.

Krier, F., Mantanus, J., Sacre, P.-Y., Chavez, P.-F., Thiry, J., Pestieau, A., Rozet, E., Ziemons, E., Hubert, P., & Evrard, B. (2013). PAT tools for the control of co-extrusion implants manufacturing process. International Journal of Pharmaceutics, 458, 15-24. doi:10.1016/j.ijpharm.2013.09.040
Peer Reviewed verified by ORBi

Thiry, J., Krier, F., Pestieau, A., & Evrard, B. (2013). Preformulation study of an itraconazole-based drug using hot-melt extrusion [Paper presentation]. 17ème Forum des Sciences Pharmaceutiques.

Krier, F., mantanus, J., Ziemons, E., Hubert, P., & Evrard, B. (16 October 2012). Comparison of in-line active content determination of polymeric implant by near infrared spectroscopy and Raman spectroscopy [Poster presentation]. Congrés annuel de l'AAPS2012.

Donnez, J., Van Langendonkt, A., Defrère, S., Foidart, J.-M., Jérôme, C., Evrard, B., Riva, R., Krier, F., & Mestdagt, M. (19 July 2012). Implant comprising a core and a tube encasing the core.

Donnez, J., Van Langendonkt, A., Defrère, S., Foidart, J.-M., Jérôme, C., Evrard, B., Riva, R., Krier, F., & Mestdagt, M. (18 July 2012). Implant comprising a core and a tube encasing the core.

Lebrun, P., Krier, F., Mantanus, J., Grohganz, H., Yang, M., Rozet, E., Boulanger, B., Evrard, B., Rantanen, J., & Hubert, P. (2012). Design space approach in the optimization of the spray-drying process. European Journal of Pharmaceutics and Biopharmaceutics, 80 (1), 226-234. doi:10.1016/j.ejpb.2011.09.014
Peer Reviewed verified by ORBi

Krier, F., Mantanus, J., Ziemons, E., & Evrard, B. (October 2011). In-line active content determination of polymeric implant by near infrared spectroscopy [Poster presentation]. AAPS Annual Meeting and Exposition, Washington, United States.

Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Krier, F., Evrard, B., & Hubert, P. (June 2011). La spectroscopie vibrationnelle, outil indispensable pour l'industrie pharmaceutique ?

Defrère, S., Mestdagt, M., Riva, R., Krier, F., Van Langendonckt, A., Drion, P., Jérôme, C., Evrard, B., Dehoux, P., Foidart, J.-M., & Donnez, J. (2011). In vivo biocompatibility of three potential intraperitoneal implants. Macromolecular Bioscience, 11 (10), 1335-45. doi:10.1002/mabi.201100077
Peer Reviewed verified by ORBi

Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Ziemons, E., Evrard, B., & Hubert, P. (2011). Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities. Journal of Pharmaceutical and Biomedical Analysis, 54, 694-700. doi:10.1016/j.jpba.2010.10.022
Peer Reviewed verified by ORBi

Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Ziemons, E., Evrard, B., & Hubert, P. (15 November 2010). Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities [Poster presentation]. The FIP Pharmaceutical Sciences World Congress 2010 in association with the AAPS Annual Meeting & Exposition, new orléans, United States.

Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Evrard, B., & Hubert, P. (September 2010). Optimisation and validation of a fast HPLC method for the quantitation of sulindac and its impurities [Poster presentation]. Drug Analysis 2010, Anvers (Antwerp), Belgium.

Krier, F., Riva, R., Mestdagt, M., van langendonckt, A., Jérôme, C., Piel, G., & Evrard, B. (June 2009). Development of an intraperitoneal implant for abdomino-pelvic chronic diseases [Poster presentation]. 2nd Pharmaceutical Sciences Fair and Exhibition - PharmSciFair 2009, Nice, Belgium.

Krier, F., Riva, R., Mestdagt, M., van langendonckt, A., Jérôme, C., Piel, G., & Evrard, B. (June 2009). Development of an intraperitoneal implant for abdomino-pelvic chronic diseases [Poster presentation]. Pre-Satellite Young Scientists Meeting, nice, France.

Krier, F., Evrard, B., Piel, G., & Riva, R. (03 February 2009). Développement d'un implant intra-péritonéal contre l'endométriose [Paper presentation]. Forum des Jeunes Chercheurs du CIRM, Liège, Belgium.

Krier, F., Nizet, D., Riva, R., Mestdagt, M., Frankenne, F., Jérôme, C., Piel, G., & Evrard, B. (2008). DEVELOPMENT OF AN INTRAPERITONEAL IMPLANT FOR THE ENDOMETRIOSIS TREATMENT [Poster presentation]. 6th World Meeting on Pharmaceutics, biopharmaceutics and pharmaceutical technology, Barcelone, Spain.

Nizet, D., Zalfen, A., Collard, L., Krier, F., Jérôme, C., Frankenne, F., Delattre, L., & Evrard, B. (2007). Development of an original intra-uterine implant allowed specific release kinetics of several drugs [Poster presentation]. Innovation in drug delivery: from biomaterials to devices, Naples, Italy.

Krier, F., Nizet, D., Riva, R., colombo, M., Frankenne, F., Jérôme, C., Piel, G., Delattre, L., & Evrard, B. (2007). DEVELOPMENT OF AN INTRAPERITONEAL IMPLANT FOR THE ENDOMETRIOSIS TREATMENT [Paper presentation]. XIIIth Forum of Pharmaceutical Sciences, Spa, Belgium.

Nizet, D., Zalfen, A., Collard, L., Krier, F., Jérôme, C., Frankenne, F., Maquet, V., Delattre, L., & Evrard, B. (2007). Controlled release of drugs from an original multi-component device [Poster presentation]. Biomedica 2007, aachen, Germany.

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