  | Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., De Tullio, P., Beaufour, C., Botez, I., Pickering, D., Frydenvang, K., Danober, L., Skov Kristensen, A., Sandholm Kastrup, J., & Pirotte, B. (09 December 2023). Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. European Journal of Medicinal Chemistry, 264, 116036. doi:10.1016/j.ejmech.2023.116036  Peer Reviewed verified by ORBi |
  | Goffin, E., Fraikin, P., Abboud, D., De Tullio, P., Beaufour, C., Botez, I., Hanson, J., Danober, L., Francotte, P., & Pirotte, B. (15 March 2023). New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. European Journal of Medicinal Chemistry, 250, 115221. doi:10.1016/j.ejmech.2023.115221 Peer Reviewed verified by ORBi |
 | Pirotte, B., De Tullio, P., Nguyen, Q.-A., Somers, F., Fraikin, P., Florence, X., Wahl, P., Hansen, J. B., & Lebrun, P. (2010). Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity. Journal of Medicinal Chemistry, 53, 147-154. doi:10.1021/jm9010093 Peer Reviewed verified by ORBi |
 | Francotte, P., Goffin, E., Fraikin, P., Lestage, P., Van Heugen, J.-C., Gillotin, F., Danober, L., Thomas, J.-Y., Chiap, P., Caignard, D.-H., Pirotte, B., & De Tullio, P. (2010). New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors. Journal of Medicinal Chemistry, 53, 1700-1711. doi:10.1021/jm901495t Peer Reviewed verified by ORBi |
Francotte, P., De Tullio, P., Fraikin, P., Goffin, E., Dintilhac, G., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D. H., & Pirotte, B. (May 2008). Development of cognitive enhancers acting through AMPA potentiation: design of novel benzothiadiazine 1,1-dioxides with improved pharmacokinetic profile [Paper presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France. |
 | Francotte, P., De Tullio, P., Podona, T., Diouf, O., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2008). Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators. Bioorganic and Medicinal Chemistry, 16 (23), 9948-56. doi:10.1016/j.bmc.2008.10.036 Peer Reviewed verified by ORBi |
 | Francotte, P., De Tullio, P., Goffin, E., Dintilhac, G., Graindorge, E., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2007). Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. Journal of Medicinal Chemistry, 50 (13), 3153-3157. doi:10.1021/jm070120i Peer Reviewed verified by ORBi |
Francotte, P., Fraikin, P., De Tullio, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (June 2006). Design, synthèse et évaluation pharmacologique de 1,2,4-pytridothiadiazine 1,1-dioxydes en tant que nouveaux potentiateurs AMPA [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France. |
 | Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., & Pirotte, B. (2006). In Search of Novel Ampa Potentiators. Recent Patents on CNS Drug Discovery, 1 (3), 239-46. doi:10.2174/157488906778773661 Peer reviewed |
 | Francotte, P., De Tullio, P., Fraikin, P., & Pirotte, B. (2006). New trends in the design of drugs against Alzheimer disease. Frontiers in Medicinal Chemistry, 3, 249-284. Peer reviewed |
 | Francotte, P., Fraikin, P., De Tullio, P., Pirotte, B., Lestage, P., Danober, L., Caignard, D.-H., & Renard, P. (27 July 2005). Preparation of fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators. |
Francotte, P., Fraikin, P., De Tullio, P., Boverie, S., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (May 2005). Modulateurs allostériques positifs des récepteurs AMPA de la classe des 1,2,4-benzothiadiazine 1,1-dioxydes : conception, synthèse et évaluation pharmacologique [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium. |
Francotte, P., Fraikin, P., De Tullio, P., Boverie, S., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (August 2004). Synthesis and biological evaluation of novel 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. XVIIIth ISMC, Copenhague, Denmark. |
Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D. H., De Tullio, P., & Pirotte, B. (June 2004). Prodrogues de modulateurs allostériques positifs des récepteurs AMPA apparentés à l’IDRA-21 : design, synthèse, étude de la stabilité et évaluation pharmacologique [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg. |
Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D. H., De Tullio, P., & Pirotte, B. (May 2004). Prodrugs of AMPA potentiators structurally related to IDRA-21: design, preparation, hydrolysis study and pharmacological evaluation [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium. |
 | Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D.-H., De Tullio, P., & Pirotte, B. (2004). Produgs of AMPA potentiators structurally related to IDRA21 : design, preparation, hydrolysis study and pharmacological evaluation. Fundamental and Clinical Pharmacology, 595. Peer Reviewed verified by ORBi |
