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Bebrone Carine

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Relations académiques et scientifiques (Médecine)

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Main Referenced Co-authors
Galleni, Moreno  (29)
Frère, Jean-Marie  (22)
Hoffmann, Kurt (16)
Delbrück, Heinrich (10)
Anne, Christine  (8)
Main Referenced Keywords
bacterial resistance (3); antibiotic resistance (2); inhibitor (2); 3D structure (1); active site (1);
Main Referenced Unit & Research Centers
CIP - Centre d'Ingénierie des Protéines - ULiège [BE] (2)
CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège [BE] (1)
Center for Education and Research on Macromolecules (CERM) (1)
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège [BE] (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (55)
Microbiology (3)
Chemistry (2)
Materials science & engineering (1)
Biotechnology (1)

Publications (total 58)

The most downloaded
2109 downloads
Bebrone, C. (15 December 2007). Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily. Biochemical Pharmacology, 74 (12), 1686-1701. doi:10.1016/j.bcp.2007.05.021 https://hdl.handle.net/2268/6570

The most cited

424 citations (Scopus®)

Bebrone, C. (15 December 2007). Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily. Biochemical Pharmacology, 74 (12), 1686-1701. doi:10.1016/j.bcp.2007.05.021 https://hdl.handle.net/2268/6570

Blackman, G., Fastrez, S., Gathy, C., Bebrone, C., Vandegaart, H., & Duysens, G. (22 July 2021). Composition comprising at least one detergent component and at least one enzyme component for removing biofilms.

Gavara, L., Sevaille, L., De Luca, F., Mercuri, P., Bebrone, C., Feller, G., Legru, A., Cerboni, G., Tanfoni, S., Baud, D., Cutolo, G., Bestgen, B., Chelini, G., Verdirosa, F., Sannio, F., Pozzi, C., Benvenuti, M., Kwapien, K., Fischer, M., ... Hernandez, J.-F. (2020). 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-beta-lactamase inhibitors. European Journal of Medicinal Chemistry, 208, 112720. doi:10.1016/j.ejmech.2020.112720
Peer Reviewed verified by ORBi

Parilti, R., Caprasse, J., Riva, R., Alexandre, M., Vandegaart, H., Bebrone, C., Dupont-Gillain, C., Howdle, S. M., & Jérôme, C. (15 December 2018). Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide. Journal of Colloid and Interface Science, 532, 112-117. doi:10.1016/j.jcis.2018.07.125
Peer Reviewed verified by ORBi

Bebrone, C., Alexandre, M., Vandegaart, H., Duysens, G., & Nicaise, D. (16 November 2017). Composition principalement peptidique pour la détection de l'amiante.

Bebrone, C., Vandegaart, H., & Nicaise, D. (23 February 2017). Asbestos detection.

Sevaille, L., Gavara, L., Bebrone, C., De Luca, F., Nauton, L., Achard, M., Mercuri, P., Tanfoni, S., Borgianni, L., Guyon, C., Lonjon, P., Turan-Zitouni, G., Dzieciolowski, J., Becker, K., Bénard, L., Condon, C., Maillard, L., Martinez, J., Frère, J.-M., ... Hernandez, J.-F. (2017). 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases. ChemMedChem, 12, 972-985. doi:10.1002/cmdc.201700186
Peer Reviewed verified by ORBi

Bebrone, C., & Van de Weerdt, C. (2016). Le biomimétisme moléculaire : du concept universitaire à l'application industrielle [Paper presentation]. Liège Créative, Liège, Belgium.

Camporeale, G., Moreno-Couranjou, M., Bonot, S., Mauchauffé, R., Boscher, N., Bebrone, C., Van de Weerdt, C., Cauchie, H.-M., Favia, P., & Choquet, P. (15 May 2015). Atmospheric-Pressure Plasma Deposited Epoxy-Rich Thin Films as Platforms for Biomolecule Immobilization-Application for Anti-Biofouling and Xenobiotic-Degrading Surfaces. Plasma Processes and Polymers, 12 (11), 1208-1219. doi:10.1002/ppap.201400206
Peer Reviewed verified by ORBi

Kupper, M. B., Herzog, K., Bennink, S., Schlömer, P., Bogaerts, P., Glupczynski, Y., Fischer, R., Bebrone, C.* , & Hoffmann, K.*. (13 April 2015). The three-dimensional structure of VIM-31a metallo-blactamase from Enterobacter cloacae in its native and oxidized form. FEBS Journal, 282 (12), 2352-2360. doi:10.1111/febs.13283
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Bebrone, C. (2014). Fonctionnaliser les surfaces avec des biomolécules fonctionnelles: vers de nouveaux matériaux bioactifs [Paper presentation]. Congrès dentaire de la Société Francophone des Biomatériaux Dentaires, Liège, Belgium.

Bebrone, C. (2013). Zinc Beta-lactamase superfamily. In R. Kretsinger, V. Uversky, ... E. Permyakov (Eds.), Encyclopedia of Metalloproteins. Springer.
Peer reviewed

Bebrone, C., Bogaerts, P., Delbrück, H., Bennink, S., Kupper, M., Rezende de Castro, R., Glupczynski, Y., & Hoffmann, K. (January 2013). GES-18, a new carbapenem-hydrolyzing GES-Type β-lactamase from pseudomonas aeruginosa that contains Ile80 and Ser170 residues. Antimicrobial Agents and Chemotherapy, 57(1), 396-401. doi:10.1128/AAC.01784-12
Peer Reviewed verified by ORBi

Delbrück, H., Bogaerts, P., Kupper, M., Rezende de Castro, R., Bennik, S., Glupczynski, Y., Galleni, M., Hoffmann, K., & Bebrone, C. (November 2012). Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 β-lactamases. Antimicrobial Agents and Chemotherapy, 56(11), 5618-5625. doi:10.1128/AAC.01272-12
Peer Reviewed verified by ORBi

Bebrone, C., Garau, G., Garcia-Saez, I., Chantalat, L., Carfi, A., & Dideberg, O. (2012). X-RAY STRUCTURES AND MECHANISMS OF METALLO-beta-LACTAMASES. In J.-M. Frère (Ed.), Beta-Lactamases (Molecular Anatomy and Physiology of Proteins). Nova Science Publishers.

Bogaerts, P., Bebrone, C., Huang, T.-D., Bouchahrouf, W., DeGheldre, Y., Deplano, A., Hoffmann, K., & Glupczynski, Y. (June 2012). Detection and characterization of VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in a clinical isolate of Enterobacter cloacae. Antimicrobial Agents and Chemotherapy, 56(6), 3283-3287. doi:10.1128/AAC.06249-11
Peer Reviewed verified by ORBi

Bebrone, C., Bogaerts, P., Delbrück, H., Rezende de Castro, R., Kupper, M. B., Glupczynski, G., & Hoffmann, K. (2012). Biochemical characterisation of GES-18 carbapenemase with an additional Val80Ile substitution compared to GES-5 [Poster presentation]. 22th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Londres, United Kingdom.
Peer reviewed

Kupper, M., Bauvois, C., Frère, J.-M., Galleni, M., & Bebrone, C. (January 2012). The CphAII protein from Aquifex aeolicus exhibits a metal-dependent phosphodiesterase activity. Extremophiles: Life Under Extreme Conditions, 16(1), 45-55. doi:10.1007/s00792-011-0404-1
Peer Reviewed verified by ORBi

Bogaerts, P., Bebrone, C., Te-Din, H., Bouchahrouf, W., DeGheldre, Y., Hoffmann, K., & Glupczynski, G. (2012). Detection and characterization of a new VIM-31 variant in Enterobacter cloacae [Poster presentation]. 22th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Londres, United Kingdom.
Peer reviewed

El Garch, F., Bogaerts, P., Bebrone, C., Galleni, M., & Glupczynski, Y. (October 2011). OXA-198, an acquired carbapenem-hydrolyzing class D beta-lactamase from Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 55(10), 4828-4833. doi:10.1128/AAC.00522-11
Peer Reviewed verified by ORBi

Horsfall, L., Izougarhane, Y., Lassaux, P., Selevsek, N., Liénard, B., Poirel, L., Kupper, M., Hoffmann, K., Frère, J.-M., Galleni, M., & Bebrone, C. (April 2011). Broad antibiotic resistance profile of the subclass B3 metallo-β-lactamase GOB-1, a di-zinc enzyme. FEBS Journal, 278(8), 1252-1263. doi:10.1111/j.1742-4658.2011.08046.x
Peer Reviewed verified by ORBi

Bebrone, C., Delbrück, H., Kupper, M. B., Galleni, M., & Hoffmann, K. (2011). The structure of the C221D mutant of the subclass B2 CphA metallo-beta-lactamase shows a modification of the typical alpha beta beta alpha fold [Poster presentation]. 11th β-lactamase meeting, Leonessa, Italy.
Peer reviewed

Bebrone, C., Kupper, M. B., Dehareng, D., Frère, J.-M., Hoffmann, K., & Galleni, M. (2011). The CphAII protein from Aquifex aeolicus possesses a metal-dependent phosphodiesterase activity [Poster presentation]. 11th β-lactamase meeting, Leonessa, Italy.
Peer reviewed

Bebrone, C., Delbrück, H., Kupper, M. B., Ervenich, D., Hoffmann, K., & Galleni, M. (2011). The C221D mutation leads to a modification of the Metallo-beta-Lactamase fold of CphA [Poster presentation]. IAP P6/19 project: PROFUSA meeting, Liège, Belgium.
Peer reviewed

Naik, A., Beck, J., Dîrtu, M., Bebrone, C., Tinant, B., Robeyns, K., Marchand-Brynaerts, J., & Garcia, Y. (2011). Zinc complexes with 1,2,4-triazole functionalized amino acid derivatives: Synthesis, structure and b-lactamase assay. Inorganica Chimica Acta, 368, 21-28. doi:10.1016/j.ica.2010.12.017
Peer Reviewed verified by ORBi

El Garch, F., Bogaerts, P., Bebrone, C., Galleni, M., & Glupczynski, G. (2011). Identification of OXA-198, a new carbapenem hydrolyzing class D beta-lactamase, in Pseudomonas aeruginosa [Poster presentation]. 21th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Milan, Italy.
Peer reviewed

Naik, A. D., Beck, J., Dirtu, M. M., Bebrone, C., Tinant, B., Robeyns, K., Marchand-Brynaert, J., & Garcia, Y. (2011). Zinc complexes with 1,2,4-triazole functionalized amino acid derivatives: Synthesis, structure and beta-lactamase assay [Poster presentation]. EDT-CHIM-Liege meeting, Liège, Belgium.

Weide, T., Saldanha, S. A., Minond, D., Spicer, T., Fotsing, J., Spaargaren, M., Frère, J.-M., Bebrone, C., Sharpless, B., Hodder, P., & Fokin, V. (July 2010). NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β- Lactamase: Synthesis and Structure-Activity Studies. ACS Medicinal Chemistry Letters, 1(4), 150-154.
Peer Reviewed verified by ORBi

Bebrone, C., Lassaux, P., Vercheval, L., Sohier, J., Jehaes, A., Sauvage, E., & Galleni, M. (16 April 2010). Current challenges in antimicrobial chemotherapy: focus on beta-lactamase inhibition. Drugs, 70(6), 651-679. doi:10.2165/11318430-000000000-00000
Peer Reviewed verified by ORBi

Lassaux, P., Hamel, M., Gulea, M., Delbrück, H., Mercuri, P., Horsfall, L., Dehareng, D., Kupper, M., Frère, J.-M., Hoffmann, K., Galleni, M., & Bebrone, C. (2010). Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-β-lactamases. Journal of Medicinal Chemistry, 53, 4862–4876. doi:10.1021/jm100213c
Peer Reviewed verified by ORBi

Lassaux, P., Delbrück, H., Gulea, M., Kupper, M., Hoffmann, K., Galleni, M., & Bebrone, C. (2010). Interactions mediating the positioning of mercapto-phosphonate inhibitors in the active site of metallo-beta-lactamases [Paper presentation]. ECCMID, Vienne, Austria.
Peer reviewed

Minond, D., Saldanha, S. A., Spaargaren, M., Spicer, T., Fotsing, J. R., Weide, T., Fokin, V. V., Sharpless, K. B., Galleni, M., Bebrone, C., Lassaux, P., & Hodder, P. (15 July 2009). Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries. Bioorganic and Medicinal Chemistry, 17, 5027-37. doi:10.1016/j.bmc.2009.05.070
Peer Reviewed verified by ORBi

Beck, J., Vercheval, L., Bebrone, C., Herteg-Fernea, A., Lassaux, P., & Marchand-Brynaert, J. (01 July 2009). Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate. Bioorganic and Medicinal Chemistry Letters, 19, 3593-7. doi:10.1016/j.bmcl.2009.04.149
Peer Reviewed verified by ORBi

Bebrone, C., Delbrück, H., Wilmann, C., Galleni, M., Frère, J.-M., & Hoffmann, K. (2009). The structure of the di-zinc form of the subclass B2 CphA metallo-β-lactamase reveals that the second zinc ion binds in the Histidine site [Poster presentation]. “Penicillin-recognizing enzymes: from enzyme kinetics to protein folding” symposium, Liège, Belgium.

Bebrone, C., Delbrück, H., Kupper, M., Schlömer, P., Willmann, C., Frère, J.-M., Fisher, R., Galleni, M., & Hoffmann, K. (2009). The structure of the di-zinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the "histidine" site. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.00288-09
Peer Reviewed verified by ORBi

Beck, J., Gharbi, S., Herteg-Fernea, A., Vercheval, L., Bebrone, C., Lassaux, P., Zervosen, A., & Marchand-Brynaert, J. (2009). Aminophosphonic Acids and Aminobis(phosphonic acids) as Potential Inhibitors of Penicillin-Binding Proteins. European Journal of Organic Chemistry, (1), 85-97. doi:10.1002/ejoc.200800812
Peer Reviewed verified by ORBi

Hubert, S., Rigali, S., Bebrone, C., Kupper, M. B., Hoffmann, K., Vanhulle, S., & Frère, J.-M. (2008). Analysis of the enzymatic component of ligninolytic system of Pycnoporus sanguineus PS7 [Poster presentation]. International congress on Biocatalysis BIOCAT, Hambourg, Germany.
Peer reviewed

Bebrone, C., Anne, C., Kerff, F., Garau, G., De Vriendt, K., Lantin, R., Devreese, B., Van Beeumen, J., Dideberg, O., Frère, J.-M., & Galleni, M. (2008). Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila. Biochemical Journal, 414 (1), 151-9. doi:10.1042/BJ20080375
Peer Reviewed verified by ORBi

Bebrone, C., Delbrück, H., Kupper, M. B., Galleni, M., Frère, J.-M., & Hoffmann, K. (2008). The structure of the di-zinc form of the subclass B2 CphA metallo-β-lactamase reveals that the second zinc binds in the Histidine site [Poster presentation]. International congress on Biocatalysis BIOCAT, Hambourg, Germany.
Peer reviewed

Bebrone, C. (2008). Emerging antimicrobial resistance: mechanisms, management and control [Paper presentation]. Alpha Bacterialnet, Florence/Sienne, Italy.

Bebrone, C. (15 December 2007). Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily. Biochemical Pharmacology, 74 (12), 1686-1701. doi:10.1016/j.bcp.2007.05.021
Peer Reviewed verified by ORBi

Lassaux, P., Hamel, M., Gulea, M., Mercuri, P., Horsfall, L., Bebrone, C., Gaumont, A.-C., Frère, J.-M., & Galleni, M. (2007). Mercapto-phosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. International Journal of Antimicrobial Agents, 29 (Supplément 2), 95.
Peer Reviewed verified by ORBi

De Vriendt, K., Van Driessche, G., Devreese, B., Bebrone, C., Anne, C., Frère, J.-M., Galleni, M., & Van Beeumen, J. (February 2006). Monitoring the zinc affinity of the metallo-beta-lactamase CphA by automated nanoESI-MS. Journal of the American Society for Mass Spectrometry, 17 (2), 180-188. doi:10.1016/j.jasms.2005.10.007
Peer Reviewed verified by ORBi

Trovaslet, M., Bebrone, C., Enaud, E., Hubert, S., Nouaimeh, N., Pamplona, M., Lorenzini, B., Bols, C.-M., Frère, J.-M., & Corbisier, A.-M. (2006). Kinetic activation of Pycnoporus sanguineus laccase in presence of dyes [Poster presentation]. 3rd European Meeting in Oxizymes, Oeiras, Portugal.
Peer reviewed

Bebrone, C., Anne, C., De Vriendt, K., Devreese, B., Rossolini, G. M., Van Beeumen, J., Frère, J.-M., & Galleni, M. (05 August 2005). Dramatic broadening of the substrate profile of the Aeromonas hydrophila CphA metallo-beta-lactamase by site-directed mutagenesis. Journal of Biological Chemistry, 280 (31), 28195-28202. doi:10.1074/jbc.M414052200
Peer Reviewed verified by ORBi

Bebrone, C. (2005). Caractérisation des résidus impliqués dans le mécanisme d’action et la spécificité de la beta-lactamase de classe B Cpha [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/301353

Garau, G., Bebrone, C., Anne, C., Galleni, M., Frère, J.-M., & Dideberg, O. (28 January 2005). A metallo-beta-lactamase enzyme in action: Crystal structures of the monozinc carbapenemase CphA and its complex with biapenem. Journal of Molecular Biology, 345 (4), 785-795. doi:10.1016/j.jmb.2004.10.070
Peer Reviewed verified by ORBi

Bebrone, C. (2005). CphA, un exemple pratique de beta-lactamase à zinc [Paper presentation]. Séminaire IRMW, Bruxelles, Belgium.

Garau, G., Garcia-Saez, I., Bebrone, C., Anne, C., Mercuri, P., Galleni, M., Frère, J.-M., & Dideberg, O. (July 2004). Update of the standard numbering scheme for class B beta-lactamases. Antimicrobial Agents and Chemotherapy, 48 (7), 2347-2349. doi:10.1128/AAC.48.7.2347-2349.2004
Peer Reviewed verified by ORBi

Vanhove, M., Zakhem, M., Devreese, B., Franceschini, N., Anne, C., Bebrone, C., Amicosante, G., Rossolini, G. M., Van Beeumen, J., Frère, J.-M., & Galleni, M. (2003). Role of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-beta-lactamase. Cellular and Molecular Life Sciences, 60 (11), 2501-9. doi:10.1007/s00018-003-3092-x
Peer Reviewed verified by ORBi

Bebrone, C., Anne, C., & Galleni, M. (2003). Modification of the specificity of the CphA metallo- β-lactamase produced by Aeromonas hydrophila by site-directed mutagenesis [Poster presentation]. Bioforum, Liège, Belgium.

De Seny, D., Prosperi, C., Bebrone, C., Rossolini, G. M., Page, M. I., Noel, P., Frère, J.-M., & Galleni, M. (01 May 2002). Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase. Biochemical Journal, 363 (Pt 3), 687-696. doi:10.1042/bj3630687
Peer Reviewed verified by ORBi

Bebrone, C., Anne, C., & Galleni, M. (2002). Molecular evolution of the Aeromonas hydrophila CphA metallo-β-lactamase [Poster presentation]. Engineering enzymes for biocatalysis by using directed evolution, Paris, France.
Peer reviewed

Bebrone, C., Moali, C., Mahy, F., Rival, S., Docquier, J.-D., Rossolini, G. M., Fastrez, J., Pratt, R. F., Frère, J.-M., & Galleni, M. (June 2001). Centa as a Chromogenic Substrate for Studying Beta-Lactamases. Antimicrobial Agents and Chemotherapy, 45 (6), 1868-71. doi:10.1128/AAC.45.6.1868-1871.2001
Peer Reviewed verified by ORBi

Bebrone, C. (2001). Modification of the specificity of CphA metallo-beta-lactamase by site-directed and random mutagenesis [Paper presentation]. EU-network meeting on zinc ion containing beta-lactamases, Sienne, Italy.

Bebrone, C., Fastrez, J., Frère, J.-M., & Galleni, M. (2001). Centa as a chromogenic substrate for the study of β-lactamases [Poster presentation]. Bioforum, Liège, Belgium.

Bebrone, C. (2000). Study of the Aeromonas hydrophila class B2 metallo-beta-lactamase: catalytic mechanism and specificity [Paper presentation]. EU-network meeting on zinc ion containing beta-lactamases, Copenhague, Denmark.

Bebrone, C. (1999). Etude du mécanisme d’action de la beta-lactamase à zinc de Bacillus cereus [Master’s dissertation, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/301354

Bebrone, C. (1999). Mutational study of the two zinc binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase [Paper presentation]. EU-Network meeting on zinc ion containing beta-lactamases, Saarbrücken, Germany.

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