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Dogné Jean-Michel

Département des sciences biomédicales et précliniques

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Main Referenced Co-authors
Pirotte, Bernard  (36)
Kolh, Philippe  (32)
Ghuysen, Alexandre  (29)
Hanson, Julien  (29)
Lambermont, Bernard  (29)
Main Referenced Keywords
hemodynamics (7); atherosclerosis (5); BM-573 (4); contractile function (4); septic shock (4);
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (39)
Cardiovascular & respiratory systems (20)
Biochemistry, biophysics & molecular biology (6)
Anesthesia & intensive care (5)
Hematology (5)

Publications (total 72)

The most downloaded
442 downloads
Delanaye, P., Lambermont, B., Dogné, J.-M., Dubois, B., Ghuysen, A., Janssen, N., Desaive, T., Kolh, P., D'Orio, V., & Krzesinski, J.-M. (October 2006). Confirmation of high cytokine clearance by hemofiltration with a cellulose triacetate membrane with large pores: an in vivo study. International Journal of Artificial Organs, 29 (10), 944-948. doi:10.1177/039139880602901004 https://hdl.handle.net/2268/6279

The most cited

123 citations (Scopus®)

Jaspart, S., Bertholet, P., Piel, G., Dogné, J.-M., Delattre, L., & Evrard, B. (January 2007). Solid lipid microparticles as a sustained release system for pulmonary drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 65 (1), 47-56. doi:10.1016/j.ejpb.2006.07.006 https://hdl.handle.net/2268/12204

Cherdon, C., Rolin, S., Ooms, A., de Leval, L., Drion, P., Defraigne, J.-O., & Dogné, J.-M. (2009). Le bm-573, un antagoniste original du récepteur au thromboxane a2, réduit le développement des lésions athéromateuses chez des souris déficientes en apolipoprotéine e (apo e-/-) contrairement a l’aspirine [Paper presentation]. 21ème Journées Franco-Belges de Pharmaco chimie, 28 et 29 mai 2009, , Belgique, Mons, Belgium.
Peer reviewed

Delanaye, P., Janssen, N., Dogné, J.-M., Dubois, B., Ghuysen, A., Kolh, P., D'Orio, V., Desaive, T., Krzesinski, J.-M., & Lambermont, B. (2009). Influence de la largeur des pores des membranes utilisées au cours de l’hémofiltration et du débit d’ultrafiltration sur la clairance plasmatique de l’interleukine 6 dans un modèle porcin de choc septique [Poster presentation]. 37ème congrès de la Société de Réanimation de Langue Française, Paris, France.

Robert, S., Ghiotto, J., Pirotte, B., David, J.-L., Masereel, B., Pochet, L., & Dogné, J.-M. (2009). Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs ? Pharmacological Research, 59, 160-166. doi:10.1016/j.phrs.2008.12.003
Peer Reviewed verified by ORBi

Cherdon, C., Rolin, S., de Leval, L., Drion, P., Dogné, J.-M., & Defraigne, J.-O. (2008). Study of thromboxane modulators in a murine model of atherosclerosis [Paper presentation]. PhD Students’ day (Doctoral school of Physiology and Pharmacology), Namur, Belgium.
Peer reviewed

Cherdon, C., Rolin, S., Hanson, J., Drion, P., de Leval, L., Dogné, J.-M., & Defraigne, J.-O. (11 October 2007). Bm-573, an original thromboxane receptor antagonist, reduces development of atherosclerosis in apoe–deficient (apo e-/-) mice [Poster presentation]. Treizième forum des sciences pharamceutiques, Spa, Belgium.

Cherdon, C., Rolin, S., Hanson, J., Drion, P., de Leval, L., Defraigne, J.-O., & Dogné, J.-M. (22 June 2007). Bm-573, a thromboxane receptor antagonist, reduces development of atherosclerosis in apoe–deficient mice [Poster presentation]. FROM CELL TO MAN TO SOCIETY - XIX World Congress of the ISHR, Bologne, Italy.

Kolh, P., Tchana-Sato, V., Ghuysen, A., Lambermont, B., Rolin, S., D'Orio, V., Limet, R., & Dogné, J.-M. (June 2007). Comparative effects on LV performance, arterial hemodynamics and ventriculo-arterial coupling of two models of coronary artery occlusion in pigs. European Journal of Heart Failure, 6 (Suppl. 1), 82. doi:10.1016/S1567-4215(07)60229-X
Peer Reviewed verified by ORBi

Cherdon, C., Rolin, S., Hanson, J., Drion, P., de Leval, L., Defraigne, J.-O., & Dogné, J.-M. (10 May 2007). Le bm-573, un antagoniste original de récepteur au thromboxane a2, réduit le développement des lesions atheromateuses chez des souris deficientes en apolipoproteine e (apo e-/-) [Poster presentation]. 21ème Journées Franco-Belges de Pharmaco chimie, , Namur, Belgique, Namur, Belgium.

Jaspart, S., Bertholet, P., Piel, G., Dogné, J.-M., Delattre, L., & Evrard, B. (January 2007). Solid lipid microparticles as a sustained release system for pulmonary drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 65 (1), 47-56. doi:10.1016/j.ejpb.2006.07.006
Peer Reviewed verified by ORBi

Lanoye, L., Segers, P., Tchana-Sato, V., Rolin, S., Dogné, J.-M., Ghuysen, A., Lambermont, B., Hanson, J., Desaive, T., Verdonck, P., D'Orio, V., & Kolh, P. (01 January 2007). Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion. Experimental Physiology, 92 (1), 127-137. doi:10.1113/expphysiol.2006.034983
Peer Reviewed verified by ORBi

Cherdon, C., Rolin, S., Hanson, J., Drion, P., De Leval, L., Defraigne, J.-O., & Dogné, J.-M. (2007). BM-573, a thromboxane receptor antagonist, reduces development of atherosclerosis in apoE–deficient mice. Journal of Molecular and Cellular Cardiology, 42 (suppl 1.), 33-34. doi:10.1016/j.yjmcc.2007.03.095
Peer Reviewed verified by ORBi

Hanson, J., Dogné, J.-M., Ghiotto, J., Moray, A.-L., Kinsella, B. T., & Pirotte, B. (2007). Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]lureas and -cyanoguanidine as selective antagonists of the TPalpha and TPBeta isoforms of the human thromboxane A2 receptor. Journal of Medicinal Chemistry, 50, 3928-3936. doi:10.1021/jm070427h
Peer Reviewed verified by ORBi

Rolin, S.* , Hanson, J.* , Vastersaegher, C., Cherdon, C., Pratico, D., Masereel, B., & Dogné, J.-M. (2007). BM-520, an original TXA(2) modulator, inhibits the action of thromboxane A(2) and 8-iso-prostaglandin F-2 alpha in vitro and in vivo on human and rodent platelets, and aortic vascular smooth muscles from rodents. Prostaglandins and Other Lipid Mediators, 84 (1-2), 14-23. doi:10.1016/j.prostaglandins.2007.03.002
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* These authors have contributed equally to this work.

Delanaye, P., Lambermont, B., Dogné, J.-M., Dubois, B., Ghuysen, A., Janssen, N., Desaive, T., Kolh, P., D'Orio, V., & Krzesinski, J.-M. (October 2006). Confirmation of high cytokine clearance by hemofiltration with a cellulose triacetate membrane with large pores: an in vivo study. International Journal of Artificial Organs, 29 (10), 944-948. doi:10.1177/039139880602901004
Peer Reviewed verified by ORBi

de Leval, X., Dassesse, T., Dogné, J.-M., Waltregny, D., Bellahcene, A., Benoit, V., Pirotte, B., & Castronovo, V. (September 2006). Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents. Journal of Pharmacology and Experimental Therapeutics, 318 (3), 1057-1067. doi:10.1124/jpet.106.101188
Peer Reviewed verified by ORBi

Lambermont, B., Delanaye, P., Dogné, J.-M., Ghuysen, A., Janssen, N., Dubois, B., Desaive, T., Kolh, P., D'Orio, V., & Krzesinski, J.-M. (July 2006). Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs. Artificial Organs, 30 (7), 560-564. doi:10.1111/j.1525-1594.2006.00260.x
Peer Reviewed verified by ORBi

Hanson, J., Reynaud, D., Qiao, N., Devel, P., Moray, A.-L., Renard, J.-F., Kelley, L. P., Winum, J.-Y., Montero, J.-L., Kinsella, B. T., Pirotte, B., Pace-Asciak, C. R., & Dogné, J.-M. (June 2006). Synthesis and pharmacological evaluation of novel thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor. Journal of Medicinal Chemistry, 49 (12), 3701-3709. doi:10.1021/jm060108a
Peer Reviewed verified by ORBi

Cherdon, C., Rolin, S., Hanson, J., Duwez, L., Drion, P., Pincemail, J., de Leval, L., Defraigne, J.-O., & Dogné, J.-M. (17 May 2006). The use of an apoE–deficient (apoE-/-) mice model to characterize the therapeutic benefits of original thromboxane modulators [Poster presentation]. Bioforum 2006, Liège, Belgique, Liège, Belgium.

Kolh, P., Rolin, S., Tchana-Sato, V., Petein, M., Ghuysen, A., Lambermont, B., Hanson, J., Magis, D., Segers, P., Masereel, B., D'Orio, V., & Dogné, J.-M. (March 2006). Evaluation of BM-573, a novel TXA(2) synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion. Prostaglandins and Other Lipid Mediators, 79 (1-2), 53-73. doi:10.1016/j.prostaglandins.2005.10.002
Peer Reviewed verified by ORBi

Delanaye, P., Lambermont, B., Dogné, J.-M., Dubois, B., Ghuysen, A., Janssen, N., Kolh, P., D'Orio, V., & Krzesinski, J.-M. (2006). Clairance plasmatique des cytokines IL6 et IL10 par hémofiltration avec un filtre à larges pores dans un modèle porcin de choc septique [Paper presentation]. 34ème congrès de la Société de Réanimation de Langue Française, Paris, France.

Dogné, J.-M., Hanson, J., de Leval, X., Pratico, D., Pace-Asciak, C. R., Drion, P., Pirotte, B., & Ruan, K.-H. (2006). From the design to the clinical application of thromboxane modulators [letter to the editor]. Current Pharmaceutical Design, 12 (8), 903-923. doi:10.2174/138161206776055921
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Michaux, C., De Leval, X., Julémont, F., Dogné, J.-M., Pirotte, B., & Durant, F. (2006). Structure-based pharmacophore of COX-2 selective inhibitors and identification of original lead compounds from 3D database searching method. European Journal of Medicinal Chemistry, 41, 1446-1455. doi:10.1016/j.ejmech.2006.07.017
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Desaive, T., Janssen, N., Péters, F., Ghuysen, A., Lambermont, B., Pierard, L., D'ORIO, V., Kolh, P., Gérard, P., Dogné, J.-M., Limet, R., Serteyn, D., Leroy, P., & Dauby, P. (2006). Dynamics of spontaneous ventricular fibrillation in acutely ischemic pigs. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, 8 (supplement 1), 178P/32.
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Tchana-Sato, V., Dogné, J.-M., Lambermont, B., Ghuysen, A., Magis, D., Morimont, P., Hanson, J., D'Orio, V., Limet, R., & Kolh, P. (December 2005). Effects of BM-573, a thromboxane A(2) modulator on systemic hemodynamics perturbations induced by U-46619 in the pig. Prostaglandins and Other Lipid Mediators, 78 (1-4), 82-95. doi:10.1016/j.prostaglandins.2005.04.001
Peer Reviewed verified by ORBi

Dogné, J.-M., Rolin, S., Tchana-Sato, V., Petein, M., Lambermont, B., Ghuysen, A., Hanson, J., & Kolh, P. (September 2005). Characterisation of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig. European Heart Journal, 26 (Suppl. 1), 455-456.
Peer Reviewed verified by ORBi

Kolh, P., Lambermont, B., Ghuysen, A., Tchana-Sato, V., Dogné, J.-M., Hanson, J., Gérard, P., D'Orio, V., Pierard, L., & Limet, R. (February 2005). Effects of dobutamine on left ventriculoarterial coupling and mechanical efficiency in acutely ischemic pigs. Journal of Cardiovascular Pharmacology, 45 (2), 144-152. doi:10.1097/01.fjc.0000151928.27273.02
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Hanson, J., Rolin, S., Reynaud, D., Qiao, N., Kelley, L. P., Reid, H. M., Valentin, F., Tippins, J., Kinsella, B. T., Masereel, B., Pace-Asciak, C. R., Pirotte, B., & Dogné, J.-M. (2005). In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea]. Journal of Pharmacology and Experimental Therapeutics, 313, 293-301. doi:10.1124/jpet.104.079301
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Lanoye, L., KOLH, P., Rolin, S., TCHANA-SATO, V., Dogné, J.-M., GHUYSEN, A., LAMBERMONT, B., Magis, D., Hanson, J., Segers, P., Gérard, P., Masereel, B., D'ORIO, V., & Limet, R. (2005). Effects of reperfusion on left ventricular hemodynamics and ventriculo-arterial coupling in acutely ischemic pigs. Computer Methods in Biomechanics and Biomedical Engineering, 8 (suppl. 1), 169-170.
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Michaux, C., Charlier, C., Julémont, F., De Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (2005). A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide. European Journal of Medicinal Chemistry, 40, 1316-1324. doi:10.1016/j.ejmech.2005.08.003
Peer Reviewed verified by ORBi

Dogné, J.-M., Rolin, S., Petein, M., Tchana-Sato, V., Ghuysen, A., Lambermont, B., Hanson, J., Magis, D., Segers, P., Pirotte, B., Masereel, B., Drion, P., D'Orio, V., & Kolh, P. (2005). Characterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig. Thrombosis Research, 116 (5), 431-442. doi:10.1016/j.thromres.2005.02.006
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Kolh, P., Lambermont, B., Ghuysen, A., Tchana-Sato, V., Dogné, J.-M., D'Orio, V., Gérard, P., Larbuisson, R., & Limet, R. (September 2004). Comparison of the effects of propofol and pentobarbital on left ventricular adaptation to an increased afterload. Journal of Cardiovascular Pharmacology, 44 (3), 294-301. doi:10.1097/01.fjc.0000133050.11105.c2
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Ghuysen, A., Lambermont, B., Dogné, J.-M., Kolh, P., Tchana-Sato, V., Morimont, P., Magis, D., Hanson, J., Segers, P., & D'Orio, V. (September 2004). Effect of BM-573[N-terbutyl-N '-[2-(4 '-methylphenylamino)-5-nitro-benzenesulfonyl] urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism. Journal of Pharmacology and Experimental Therapeutics, 310 (3), 964-972. doi:10.1124/jpet.104.066852
Peer Reviewed verified by ORBi

Roland, I., de Leval, X., Evrard, B., Pirotte, B., Dogné, J.-M., & Delattre, L. (August 2004). Modulation of the arachidonic cascade with omega 3 fatty acids or analogues: Potential therapeutic benefits. Mini Reviews in Medicinal Chemistry, 4 (6), 659-668. doi:10.2174/1389557043403738
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Hanson, J., Rolin, S., De Leval, X., Reynaud, D., Qiao, N., Neven, P., Masereel, B., Pace-Asciak, C. R., Pirotte, B., & Dogné, J.-M. (May 2004). In vivo evaluation of antithrombotic potency of BM-613, a thromboxane A2 receptor antagonist, in a rat model of arterial thrombosis [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Hanson, J., Rolin, S., De Leval, X., Neven, P., Masereel, B., Pirotte, B., & Dogné, J.-M. (2004). Characterization of preferential activity on platelet thromboxane A2 receptors of BM-613, a new thromboxane A2 antagonist. Fundamental and Clinical Pharmacology, 269.
Peer Reviewed verified by ORBi

Mouithys-Mickalad, A., Deby, G., Dogné, J.-M., de Leval, X., Kohnen, S., Navet, R., Sluse, F., Hoebeke, M., Pirotte, B., & Lamy, M. (2004). Effects of COX-2 inhibitors on ROS produced by Chlamydia pneumoniae-primed human promonocytic cells (THP-1). Biochemical and Biophysical Research Communications, 325 (4), 1122-1130. doi:10.1016/j.bbrc.2004.10.155
Peer reviewed

Dogné, J.-M., Hanson, J., De leval, X., Masereel, B., Kolh, P., & Pirotte, B. (2004). New developments on thromboxane modulators. Mini Reviews in Medicinal Chemistry, 649-657. doi:10.2174/1389557043403684
Peer Reviewed verified by ORBi

Dogné, J.-M., Hanson, J., De leval, X., Kolh, P., Tchana-Sato, V., de Leval, L., Rolin, S., Ghuysen, A., Segers, P., Lambermont, B., Masereel, B., & Pirotte, B. (2004). Pharmacological characterization of N-tert-butyl-N’-[2-(4’-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on bleeding time. Journal of Pharmacology and Experimental Therapeutics, 309 (2), 498-505. doi:10.1124/jpet.103.063610
Peer Reviewed verified by ORBi

Hanson, J., Renard, J.-F., Neven, P., De leval, X., Rolin, S., Pirotte, B., & Dogné, J.-M. (2004). Synthésis and pharmacological evaluation of original thromboxane A2 receptor antagonists derived from BM-573. Fundamental and Clinical Pharmacology, 596.
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Lambermont, B., Kolh, P., Ghuysen, A., Segers, P., Dogné, J.-M., Tchana-Sato, V., Morimont, P., Benoit, P., Gérard, P., Masereel, B., & D'Orio, V. (January 2004). Effect of a novel thromboxane A(2) inhibitor on right ventricular-arterial coupling in endotoxic shock. Shock, 21 (1), 45-51. doi:10.1097/01.shk.0000095935.86703.ca
Peer Reviewed verified by ORBi

Lambermont, B., Segers, P., Ghuysen, A., Tchana-Sato, V., Morimont, P., Dogné, J.-M., Kolh, P., Gérard, P., & D'Orio, V. (2004). Comparison between single-beat and multiple-beat methods for estimation of right ventricular contractility. Critical Care Medicine, 32 (9), 1886-90. doi:10.1097/01.CCM.0000139607.38497.8A
Peer Reviewed verified by ORBi

De Leval, X., Hanson, J., David, J.-L., Masereel, B., Pirotte, B., & Dogné, J.-M. (2004). New developments on thromboxane and prostacyclin modulators. Part II: prostacyclin modulators. Current Medicinal Chemistry, 11, 1243-1252. doi:10.2174/0929867043365279
Peer Reviewed verified by ORBi

Hanson, J., Kolh, P., Rolin, S., Tchana-Sato, V., De Leval, X., Petein, M., Masereel, B., Pirotte, B., Dogné, J.-M., Lambermont, B., David, J. L., & GHUYSEN, A. (2004). In vivo pharmacological evaluation of BM-573, an original thromboxane A2 receptor antagonist and thromboxane synthase inhibitor. Fundamental and Clinical Pharmacology, 270.
Peer Reviewed verified by ORBi

Dogné, J.-M., De leval, X., Hanson, J., Frederich, M., Lambermont, B., Ghuysen, A., Casini, A., Masereel, B., Ruan, K. E., Pirotte, B., & Kolh, P. (2004). New developments on thromboxane and prostacyclin modulators. Part I: thromboxane modulators. Current Medicinal Chemistry, 11, 1223-1241. doi:10.2174/0929867043365260
Peer Reviewed verified by ORBi

de Leval, X. J., Dassesse, T., Benoit, V., Pirotte, B., Merville, M.-P., David, J.-L., Castronovo, V., & Dogné, J.-M. (16 November 2003). Pharmacological evaluation of BM-573, a dual thromboxane A(2) receptor antagonist and thromboxane synthase inhibitor, as potential anti-metastatic agent. Blood, 102 (11, Part 2), 72.

Segers, P., Tchana-Sato, V., Leather, H. A., Lambermont, B., Ghuysen, A., Dogné, J.-M., Benoit, P., Morimont, P., Wouters, P. F., Kolh, P., & Verdonck, P. R. (28 October 2003). Left ventricular preload-adjusted maximal power: Clinically useful marker of LV contractility ? Circulation, 108 (17, Suppl. S), 396-396.
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Lambermont, B., Ghuysen, A., Kolh, P., Tchana-Sato, V., Segers, P., Gérard, P., Morimont, P., Magis, D., Dogné, J.-M., Masereel, B., & D'Orio, V. (01 August 2003). Effects of endotoxic shock on right ventricular systolic function and mechanical efficiency. Cardiovascular Research, 59 (2), 412-418. doi:10.1016/S0008-6363(03)00368-7
Peer Reviewed verified by ORBi

Rolin, S., Petein, M., Tchana-Sato, V., Dogné, J.-M., Benoit, P., Lambermont, B., Ghuysen, A., Kolh, P., & Masereel, B. (July 2003). BM-573, a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, prevents pig myocardial infarction induced by coronary thrombosis. Journal of Pharmacology and Experimental Therapeutics, 306 (1), 59-65. doi:10.1124/jpet.102.046607
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Lambermont, B., Ghuysen, A., Dogné, J.-M., Kolh, P., Tchana-Sato, V., Morimont, P., Benoit, P., Gérard, P., Masereel, B., & D'Orio, V. (July 2003). Effects of Bm-573, a Novel Thromboxane A2 Inhibitor, on Pulmonary Hemodynamics in Endotoxic Shock. Archives of Physiology and Biochemistry, 111 (3), 224-31. doi:10.1076/apab.111.3.224.23457
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Lambermont, B., Kolh, P., Dogné, J.-M., Ghuysen, A., Tchana-Sato, V., Morimont, P., Benoit, P., Gérard, P., Masereel, B., Limet, R., & D'Orio, V. (July 2003). Effects of U-46619 on Pulmonary Hemodynamics before and after Administration of Bm-573, a Novel Thromboxane A2 Inhibitor. Archives of Physiology and Biochemistry, 111 (3), 217-23. doi:10.1076/apab.111.3.217.23459
Peer Reviewed verified by ORBi

Segers, P., Tchana-Sato, V., Leather, H. A., Lambermont, B., Ghuysen, A., Dogné, J.-M., Benoit, P., Morimont, P., Wouters, P. F., Verdonck, P., & Kolh, P. (June 2003). Determinants of left ventricular preload-adjusted maximal power. American Journal of Physiology - Heart and Circulatory Physiology, 284 (6), 2295-H2301. doi:10.1152/ajpheart.01110.2002
Peer Reviewed verified by ORBi

Kolh, P., Lambermont, B., Ghuysen, A., D'Orio, V., Gérard, P., Morimont, P., Tchana-Sato, V., Pierard, L., Dogné, J.-M., & Limet, R. (June 2003). Alteration of left ventriculo-arterial coupling and mechanical efficiency during acute myocardial ischemia. International Angiology, 22 (2), 148-158.
Peer Reviewed verified by ORBi

Dogné, J.-M., Kolh, P., Rolin, S., Tchana-Sato, V., Hanson, J., De Leval, X., Lambermont, B., Ghuysen, A., Petein, M., de Leval, L., Masereel, B., & Pirotte, B. (2003). Antithrombotic activity of BM-573, a novel thromboxane modulator, in rat arterial thrombosis model, pig myocardial infarction model and its effect on bleeding time. Blood, 106.
Peer Reviewed verified by ORBi

Hanson, J., De Leval, X., Kolh, P., Supuran, C., Pirotte, B., & Dogné, J.-M. (2003). Update on GPIIb/IIIa antagonists. Expert Opinion on Therapeutic Patents, 13, 1173-1188. doi:10.1517/13543776.13.8.1173
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Dogné, J.-M., de Leval, X., Kolh, P., Sanna, V., Rolin, S., Michaux, C., Mauer, M., David, J.-L., Masereel, B., & Pirotte, B. (January 2003). Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 68 (1), 49-54. doi:10.1016/S0952-3278(02)00236-3
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Rolin, S., Petein, M., Tchana-Sato, V., Dogné, J.-M., Lambermont, B., Ghuysen, A., Kolh, P., & Masereel, B. (2003). A dual thromboxane inhibitor and thromboxane receptor antagonist prevents pig myocardial infarction induced by coronary thrombosis. European Heart Journal, 24 (Suppl. S), 325. doi:10.1016/S0195-668X(03)94852-4
Peer Reviewed verified by ORBi

Hanson, J., Rolin, S., De Leval, X., Neven, P., De Leval, L., Masereel, B., Pirotte, B., & Dogné, J.-M. (2003). BM-613, a new thromboxane A2 antagonist, is characterized by a preferential activity on platelet thromboxane A2 receptors. Blood, 813a-814.
Peer Reviewed verified by ORBi

Michaux, C., Charlier, C., Julémont, F., de Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (15 November 2002). Rationalization of the binding mode of pyridinic compounds derived from nimesulide, a preferential cyclooxygenase-2 inhibitor [Poster presentation]. Drug Hunting: New Targets, New Tools, New Drugs, Bruxelles, Belgium.

Michaux, C., Charlier, C., Julémont, F., de Leval, X., Dogné, J.-M., Pirotte, B., & Durant, F. (26 September 2002). Rationalization of the binding mode of pyridinic compounds derived from nimesulide, a preferential cyclooxygenase-2 inhibitor [Poster presentation]. Assemblée générale annuelle de la Société Royale de Chimie, Namur, Belgium.

Frederich, M., Dogné, J.-M., Angenot, L., & De Mol, P. (August 2002). New trends in anti-malarial agents. Current Medicinal Chemistry, 9 (15), 1435-1456. doi:10.2174/0929867023369691
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Julémont, F., de Leval, X., Neven, P., Michaux, C., Charlier, C., Pirotte, B., & Dogné, J.-M. (02 March 2002). Evaluation of pyridinic sulfonamides related to nimesulide as COX-2 selective inhibitors [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Benoit, P., De Leval, X., Pirotte, B., & Dogné, J.-M. (2002). Latest discoveries in prostaglandin receptor modulators. Expert Opinion on Therapeutic Patents, 12, 1225-1235. doi:10.1517/13543776.12.8.1225
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Dogné, J.-M., De Leval, X., Benoit, P., Rolin, S., Pirotte, B., & Masereel, B. (2002). Therapeutic potential of thromboxane inhibitors in asthma. Expert Opinion on Investigational Drugs, 275-281. doi:10.1517/13543784.11.2.275
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De Leval, X., Benoit, V., Neven, P., Benoit, P., Michaux, C., Masereel, B., Pirotte, B., David, J. L., & Dogné, J.-M. (2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation. Fundamental and Clinical Pharmacology, 245.
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De Leval, X., Benoit, V., Neven, P., Benoit, P., Michaux, C., Masereel, B., Pirotte, B., David, J.-L., & Dogné, J.-M. (2002). Effects of thromboxane A2 receptor antagonists and thromboxane synthase inhibitors on osteogenic sarcoma cell-induced platelet aggregation. Fundamental and Clinical Pharmacology, 16, 245.
Peer Reviewed verified by ORBi

Julémont, F., de Leval, X., Michaux, C., Damas, J., Charlier, C., Durant, F., Pirotte, B., & Dogné, J.-M. (2002). Spectral and crystallographic study of pyridinic analogues of nimesulide : determination of the active form of methanesulfonamides as COX-2 selective inhibitors. Journal of Medicinal Chemistry, 45, 5182-5185. doi:10.1021/jm020920n
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Julémont, F., de Leval, X., Neven, P., Michaux, C., Charlier, C., Pirotte, B., & Dogné, J.-M. (2002). Evaluation of pyridinic sulfonamides related to nimesulide as COX-2 selective inhibitors. Fundamental and Clinical Pharmacology, 246.
Peer Reviewed verified by ORBi

Michaux, C., Charlier, C., Julémont, F., Dogné, J.-M., de Leval, X., Norberg, B., Pirotte, B., & Durant, F. (2002). N-(3-Phenoxy-4-pyridinio)methanesulfonamidate. Acta Crystallographica, 88-89. doi:10.1107/S0108270101018595
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de Leval, X., David, J.-L., Neven, P., Benoit, V., Pirotte, B., Merville, M.-P., Bours, V., & Dogné, J.-M. (16 November 2001). Effects of BM-573, a dual thromboxane A(2) receptor antagonist and thromboxane synthase inhibitor, on osteogenic sarcoma cell-induced platelet aggregation. Blood, 98 (11, Part 2), 43.
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Henrotin, Y., de Leval, X., Mathy, M., Mouithys-Mickalad, A., Deby, G., Dogné, J.-M., Delarge, J., & Reginster, J.-Y. (2001). In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators. Inflammation Research, 50 (8), 391-9. doi:10.1007/PL00000261
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De Leval, X., Dogné, J.-M., Delarge, J., Pirotte, B., Dupont, G., Mathy-Hartert, M., Chahboune, J., Labasse, A., Neven, P., Reginster, J.-Y., & Henrotin, Y. (2000). Comparative effects of nimesulide, nimesulide L-lysine and nimesulide L-lysine L-arginine on human articular chondrocytes in vitro. Mediators of Inflammation, 9, 51.
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de Leval, X., Dogné, J.-M., Neven, P., Labasse, A., Delarge, J., Reginster, J.-Y., & Henrotin, Y. (1999). Effects of Nimesulide and Indometacin on Cox-1 and Cox-2: A Comparative Study. Journal de Pharmacie de Belgique, 54 (3), 89-90.
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