Thyroid dysfunction in sea bass (Dicentrarchus labrax): Underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism

Schnitzler, Joseph; Celis, Niko; Klaren, Peter; Blust, Ronnyy; Dirtu, Alin; Covaci, Adrian; Das, Krishna

doi:10.1016/j.aquatox.2011.07.019

Article (Scientific journals)

Thyroid dysfunction in sea bass (Dicentrarchus labrax): Underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism

Schnitzler, Joseph; Celis, Niko; Klaren, Peter et al.

2011 • In Aquatic Toxicology, 105, p. 438-447

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/98457

DOI
10.1016/j.aquatox.2011.07.019

PubMed
21872555

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Keywords :

Dicentrarchus labrax; thyroid; in vivo exposure

Abstract :

[en] The current study examines the effect of subchronic exposure to a mixture of Aroclor standards on thyroid hormone physiology and metabolism in juvenile sea bass. The contaminant mixture was formulated to reflect the persistent organic pollution to which the European sea bass population could conceivably be exposed (0.3, 0.6 and 1.0 g 7PCBs per g food pellets) and higher (10 g 7PCBs per g food pellets). After 120 days of exposure, histomorphometry of thyroid tissue, muscular thyroid hormone concentration and activity of enzymes involved in metabolism of thyroid hormones were assessed. Mean concentrations of 8, 86, 142, 214 and 2279 ng g−1 ww ( 7 ICES PCB congeners) were determined after 120 days exposure. The results show that the effects of PCB exposures on the thyroid system are dose-dependent. Exposure to environmentally relevant doses of PCB (0.3–1.0 g 7PCBs per g food pellets) induced a larger variability of the follicle diameter and stimulated hepatic T4 outer ring deiodinase. Muscular thyroid hormone levels were preserved thanks to the PCB induced changes in T4 dynamics. At 10 times higher concentrations (10 g 7PCBs per g food pellets) an important depression of T3 and T4 levels could be observed which are apparently caused by degenerative histological changes in the thyroid tissue.

Research Center/Unit :

MARE - Centre Interfacultaire de Recherches en Océanologie - ULiège

Disciplines :

Aquatic sciences & oceanology

Author, co-author :

Schnitzler, Joseph ; Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Océanologie

Celis, Niko

Klaren, Peter

Blust, Ronnyy

Dirtu, Alin

Covaci, Adrian

Das, Krishna ; Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Océanologie

Language :

English

Title :

Thyroid dysfunction in sea bass (Dicentrarchus labrax): Underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism

Publication date :

2011

Journal title :

Aquatic Toxicology

ISSN :

0166-445X

eISSN :

1879-1514

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

105

Pages :

438-447

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://reflexions.ulg.ac.be/thyroidebar

Funders :

FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture

Available on ORBi :

since 08 September 2011

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