Reference : Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiologi...
Scientific journals : Article
Human health sciences : Rheumatology
Human health sciences : Immunology & infectious disease
Human health sciences : Endocrinology, metabolism & nutrition
Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiological considerations for drug use
Hazes, Johanna M.W. [Erasmus Universiteit Rotterdam - EUR > Medicine > Rheumatology > >]
Coulie, Pierre G. [Université Catholique de Louvain - UCL > de Duve Institute > > >]
Geenen, Vincent mailto [Université de Liège - ULiège > > Centre d'immunologie >]
Vermeire, Severine [Katholieke Universiteit Leuven - KUL > Gastroenterology > > >]
Carbonnel, Franck [Hôpital Bicêtre > Gastroentérologie > > >]
LOUIS, Edouard [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
Masson, Pierre [Université Catholique de Louvain - UCL > de Duve Institute > > >]
De Keyser, Filip [Ghent University > Rheumatology > > >]
Oxford University Press
Yes (verified by ORBi)
United Kingdom
[en] Pregnancy ; Rheumatoid arthritis ; Disease activity ; Pregnancy outcome ; Drug treatment ; Anti-TNF
[en] It has long been known that pregnancy and childbirth have a profound effect on the disease activity of rheumatic diseases. For clinicians, the management of patients with RA wishing to become pregnant involves the challenge of keeping disease activity under control and adequately adapting drug therapy during pregnancy and post-partum. This article aims to summarize the current evidence on the evolution of RA disease activity during and after pregnancy and the use of anti-rheumatic drugs around this period. Of recent interest is the potential use of anti-TNF compounds in the preconception period and during pregnancy. Accumulating experience with anti-TNF therapy in other immune-mediated inflammatory diseases, such as Crohn’s disease, provides useful insights for the use of TNF blockade in pregnant women with RA, or RA patients wishing to become pregnant.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals

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