[en] Hepatitis B (HBV) reactivation induced by chemotherapy is problem encountered recently in the management of malignant diseases. Chemotherapy-induced HBV reactivation may ultimately lead to terminal acute liver failure. Liver transplantation (LT) currently remains the only definitive treatment option for such cases, but is generally denied to patients suffering from malignancy. Here, the authors describe 2 cases of cancer-free and HBV graft re-infection-free survival after LT performed for terminal liver failure arising from HBV reactivation induced by chemotherapy for advanced stage lymphoma. These 2 cases, and some other reports in the literature, may suggest that patients suffering from hematologic malignancies and terminal liver disease can be considered for LT if the prognosis of their hematologic malignancy is good.
Disciplines :
Gastroenterology & hepatology Surgery
Author, co-author :
Noterdaeme, Timothee
Longree, Luc
Bataille, Christian ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
DE ROOVER, Arnaud ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
LAMPROYE, Anne ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
DELWAIDE, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Yeo W, Chan PK, Zhong S, Ho WM, Steinberg JL, Tam JS, Hui P, Leung NW, Zee B, Johnson PJ. Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors. J Med Virol 2000; 62: 299-307
Kusumoto S, Tanaka Y, Mizokami M, Ueda R. Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma. Int J Hematol 2009; 90: 13-23
Ziakas PD, Karsaliakos P, Mylonakis E. Effect of prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in lymphoma: a meta-analysis of published clinical trials and a decision tree addressing prolonged prophylaxis and maintenance. Haematologica 2009; 94: 998-1005
Detry O, Honoré P, Meurisse M, Jacquet N. Cancer in transplant recipients. Transplant Proc 2000; 32: 127
Kim SG, Chun JM, Jin R, Kim JY, Won DI, Hwang YJ. Living donor liver transplantation for acute hepatic failure caused by reactivation of hepatitis B virus infection after chemotherapy for hematologic malignancy: case reports. Transplant Proc 2010; 42: 843-845
Benten D, Sterneck M, Panse J, Rogiers X, Lohse AW. Low recurrence of preexisting extrahepatic malignancies after liver transplantation. Liver Transpl 2008; 14: 789-798
Saigal S, Norris S, Srinivasan P, Muiesan P, Rela M, Heaton N, O'Grady J. Successful outcome of orthotopic liver transplantation in patients with preexisting malignant states. Liver Transpl 2001; 7: 11-15
Stange MA, Tutarel O, Pischke S, Schneider A, Strassburg CP, Becker T, Barg-Hock H, Bastürk M, Wursthorn K, Cornberg M, Ott M, Greten TF, Manns MP, Wedemeyer H. Fulminant hepatic failure due to chemotherapy-induced hepatitis B reactivation: role of rituximab. Z Gastroenterol 2010; 48: 258-263
Dillon R, Hirschfield GM, Allison ME, Rege KP. Fatal reactivation of hepatitis B after chemotherapy for lymphoma. BMJ 2008; 337: a423
Law JK, Ho JK, Hoskins PJ, Erb SR, Steinbrecher UP, Yoshida EM. Fatal reactivation of hepatitis B post-chemotherapy for lymphoma in a hepatitis B surface antigen-negative, hepatitis B core antibody-positive patient: potential implications for future prophylaxis recommendations. Leuk Lymphoma 2005; 46: 1085-1089
Detry O, De Roover A, Coimbra C, Delwaide J, Hans MF, Delbouille MH, Monard J, Joris J, Damas P, Belaïche J, Meurisse M, Honoré P. Cadaveric liver transplantation for non-acetaminophen fulminant hepatic failure: a 20-year experience. World J Gastroenterol 2007; 13: 1427-1430
Detry O, De Roover A, Honore P, Meurisse M. Brain edema and intracranial hypertension in fulminant hepatic failure: pathophysiology and management. World J Gastroenterol 2006; 12: 7405-7412
Hung CM, Jeng LB, Lee WC, Yu MC, Kuo LM, Chen MF. Fulminant hepatic failure caused by hepatitis B virus activation after chemotherapy for breast cancer treated with liver transplantation: a case report. Transplant Proc 2003; 35: 387-388
Josting A, Wolf J, Diehl V. Hodgkin disease: prognostic factors and treatment strategies. Curr Opin Oncol 2000; 12: 403-411
Diehl V, Thomas RK, Re D. Part II: Hodgkin's lymphoma-- diagnosis and treatment. Lancet Oncol 2004; 5: 19-26
Engert A, Diehl V, Franklin J, Lohri A, Dörken B, Ludwig WD, Koch P, Hänel M, Pfreundschuh M, Wilhelm M, Trümper L, Aulitzky WE, Bentz M, Rummel M, Sezer O, Müller-Hermelink HK, Hasenclever D, Löffler M. Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study. J Clin Oncol 2009; 27: 4548-4554
Norris S, Crosbie O, McEntee G, Traynor O, Nolan N, Mc-Cann S, Hegarty J. Orthotopic liver transplantation for veno- occlusive disease complicating autologous bone marrow transplantation. Transplantation 1997; 63: 1521-1524
Rosen HR, Martin P, Schiller GJ, Territo M, Lewin DN, Shackleton CR, Busuttil RW. Orthotopic liver transplantation for bone-marrow transplant-associated veno-occlusive disease and graft-versus-host disease of the liver. Liver Transpl Surg 1996; 2: 225-232
Dowlati A, Honore P, Damas P, Deprez M, Delwaide J, Fillet G, Beguin Y. Hepatic rejection after orthotopic liver transplantation for hepatic veno-occlusive disease or graftversus- host disease following bone marrow transplantation. Transplantation 1995; 60: 106-109
Hojo M, Morimoto T, Maluccio M, Asano T, Morimoto K, Lagman M, Shimbo T, Suthanthiran M. Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature 1999; 397: 530-534