Convenient grafting through approach for the preparation of stealth polymeric blood pool magnetic resonance imaging contrast agents

[en] New hydrosoluble magnetic resonance imaging (MRI) macrocontrast agents are synthesized by reversible addition fragmentation chain transfer (RAFT) copolymerization of poly(ethylene oxide) methyl ether acrylate (PEOMA) with an acrylamide bearing a ligand for gadolinium, followed by the complexation of Gd3+. This convenient and simple grafting through approach leads to macrocontrast agents with a high relaxivity at high frequency that is imparted by the restricted tumbling of the Gd3+ complex caused by its attachment to the polymer backbone. Importantly a very low protein adsorption is also evidenced by the hemolytic CH50 test. It is the result of the poly(ethylene oxide) (PEO) brush that efficiently hides the gadolinium complex and renders it stealth to the proteins of the immune system. Improved contrast and long blood circulating properties are thus expected for these macrocontrast agents.

Research Center/Unit :

Center for Education and Research on Macromolecules (CERM)

Disciplines :

Materials science & engineering
Chemistry

Author, co-author :

Grogna, Mathurin ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Cloots, Rudi ; Université de Liège - ULiège > Department of Chemistry > Laboratory of Structural Inorganic Chemistry

Luxen, André ; Université de Liège - ULiège > Department of Chemistry > Cyclotron Research Center

Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Passirani, Catherine; University of Angers (France) > INSERM

Lautram, Nolwenn; University of Angers (France) > INSERM

Desreux, Jean-François ; Université de Liège - ULiège > Department of Chemistry > Laboratory of Coordination and Radiochemistry

Detrembleur, Christophe ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Language :

English

Title :

Convenient grafting through approach for the preparation of stealth polymeric blood pool magnetic resonance imaging contrast agents

Publication date :

01 September 2011

Journal title :

Journal of Polymer Science. Part A, Polymer Chemistry

ISSN :

0887-624X

eISSN :

1099-0518

Publisher :

Wiley, New York, United States - New York

Volume :

Issue :

Pages :

3700-3708

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://onlinelibrary.wiley.com/doi/10.1002/pola.24805/pdf

Funders :

BELSPO - Politique scientifique fédérale
F.R.S.-FNRS - Fonds de la Recherche Scientifique
IISN - Institut interuniversitaire des sciences nucléaires

Available on ORBi :

since 26 August 2011

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