Convenient grafting through approach for the preparation of stealth polymeric blood pool magnetic resonance imaging contrast agents

Grogna, Mathurin; Cloots, Rudi; Luxen, André; Jérôme, Christine; Passirani, Catherine; Lautram, Nolwenn; Desreux, Jean-François; Detrembleur, Christophe

doi:10.1002/pola.24805

Reference : Convenient grafting through approach for the preparation of stealth polymeric blood p...


	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry Engineering, computing & technology : Materials science & engineering
	To cite this reference:	http://hdl.handle.net/2268/97777

Title :	Convenient grafting through approach for the preparation of stealth polymeric blood pool magnetic resonance imaging contrast agents
Language :	English
Author, co-author :	Grogna, Mathurin [Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Cloots, Rudi [Université de Liège - ULiège > Department of Chemistry > Laboratory of Structural Inorganic Chemistry > >]
	Luxen, André [Université de Liège - ULiège > Department of Chemistry > Cyclotron Research Center > >]
	Jérôme, Christine [Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Passirani, Catherine [University of Angers (France) > > INSERM > >]
	Lautram, Nolwenn [University of Angers (France) > > INSERM > >]
	Desreux, Jean-François [Université de Liège - ULiège > Department of Chemistry > Laboratory of Coordination and Radiochemistry > >]
	Detrembleur, Christophe [Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Publication date :	1-Sep-2011
Journal title :	Journal of Polymer Science. Part A, Polymer Chemistry
Publisher :	Wiley
Volume :	49
Issue/season :	17
Pages :	3700-3708
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0887-624X
e-ISSN :	1099-0518
City :	New York
Country :	NY
Keywords :	[en] Nuclear Magnetic Resonance Imaging (MRI) contrast agent
Abstract :	[en] New hydrosoluble magnetic resonance imaging (MRI) macrocontrast agents are synthesized by reversible addition fragmentation chain transfer (RAFT) copolymerization of poly(ethylene oxide) methyl ether acrylate (PEOMA) with an acrylamide bearing a ligand for gadolinium, followed by the complexation of Gd3+. This convenient and simple grafting through approach leads to macrocontrast agents with a high relaxivity at high frequency that is imparted by the restricted tumbling of the Gd3+ complex caused by its attachment to the polymer backbone. Importantly a very low protein adsorption is also evidenced by the hemolytic CH50 test. It is the result of the poly(ethylene oxide) (PEO) brush that efficiently hides the gadolinium complex and renders it stealth to the proteins of the immune system. Improved contrast and long blood circulating properties are thus expected for these macrocontrast agents.
Research centres :	Center for Education and Research on Macromolecules (CERM)
Funders :	Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The "IISN"
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/97777
DOI :	10.1002/pola.24805
Other URL :	http://onlinelibrary.wiley.com/doi/10.1002/pola.24805/pdf

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