[en] Due to genetic defects or illness some individuals require higher amounts of thiamin than are typically provided by the diet. Lipid-soluble thiamin precursors can achieve high blood levels of thiamin and result in increased concentrations in the central nervous system. High intakes of thiamin have been reported as beneficial in children with autism and attention deficit/hyperactivity disorder. The current study examined the effect of thiamin tetrahydrofurfuryl disulfide (TTFD), a lipophilic precursor, on behavior in the juvenile male DBA/2J mouse. Mice given by oral gavage deionized water or deionized water providing 100mg or 340mg TTFD/kg body weight daily for 17days, starting at postnatal day 18, were tested for effects on operant learning, social interaction, general activity level, and prepulse inhibition of acoustic startle, as well as effects on growth and select organ weights. Results indicate lower activity and altered social interaction at both treatment levels and decreased acoustic startle at the 100mg/kg level. Compared to controls, percent weight gain was lower in the TTFD-treatment groups, but percent body length increase was not affected by TTFD treatment. TTFD treatment did not influence percent organ weights as percentage of body weights. TTFD treatment resulted in increased whole brain thiamin concentrations. These results support the concept that lipophilic thiamin precursors provided during early development can affect a number of behavioral parameters. In clinical trials with children with behavior disorders, attention should be given to preventing possible adverse gastrointestinal irritant effects associated with TTFD therapy.
Research center :
Department of Nutrition, University of CA, Davis BMB/CNPRC, University of CA, Davis Giga-Neurosciences - ULiège
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Hills, Judith I.
Golub, Mari S.
Bettendorff, Lucien ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Keen, Carl L.
Language :
English
Title :
The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice
Publication date :
2012
Journal title :
Neurotoxicology and Teratology
ISSN :
0892-0362
eISSN :
1872-9738
Publisher :
Pergamon Press, New York, United States - New York
Volume :
34
Pages :
242-252
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Ames B.N., Elson-Schwab I., et al. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr 2002, 75(4):616-658.
Anonymous. Drugs in Japan 1982;6:99.
Baker H., Frank O. Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines. J Nutr Sci Vitaminol (Tokyo) 1976, 22:63-68. Suppl.
Bennett M.R., Schwartz W.J. Altered circadian rhythmicity is an early sign of murine dietary thiamine deficiency. J Neurol Sci 1999, 163(1):6-10.
Berman R.F., Pessah I.N., et al. Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol Sci 2008, 101(2):294-309.
Bettendorff L. Thiamine homeostasis in neuroblastoma cells. Neurochem Int 1995, 26(3):295-302.
Bettendorff L., Nghiem H.O., et al. A general method for the chemical synthesis of gamma-P-32-labeled or unlabeled nucleoside 5 '-triphosphates and thiamine triphosphate. Anal Biochem 2003, 322(2):190-197.
Bettendorff L., Peeters M., et al. Determination of thiamin and its phosphate esters in cultured neurons and astrocytes using an ion-pair reversed-phase high-performance liquid chromatographic method. Anal Biochem 1991, 198(1):52-59.
Bettendorff L., Wins P. Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors. FEBS J 2009, 276:2917-2925.
Bettendorff L., Wins P., et al. Subcellular localization and compartmentation of thiamine derivatives in rat brain. Biochim Biophys Acta 1994, 1222(1):1-6.
Bizot J.-C., Herpin A., et al. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Prog Neuropsychopharmacol Biol Psychiatry 2005, 29(6):928-935.
Bourin M., Petit-Demouliere B., et al. Animal models of anxiety in mice. Fundam Clin Pharmacol 2007, 21(6):567-574.
Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
Brenner A. The effects of megadoses of selected B complex vitamins on children with hyperkinesis: controlled studies with long-term follow-up. J Learn Disabil 1982, 15(5):258-264.
Casteels M., Sniekers M., et al. The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids. Biochem Soc Trans 2007, 35(Pt 5):876-880.
Curzon P., Zhang M., et al. The behavioral assessment of sensorimotor processes in the mouse. Acoustic startle, sensory gating, locomotor activity, rotarod, beam walking 2009.
Datta S. Cellular and chemical neuroscience of mammalian sleep. Sleep Med 2010, 11(5):431-440.
Djoenaidi W., Notermans S.L., et al. Beriberi cardiomyopathy. Eur J Clin Nutr 1992, 46(3):227-234.
Du Y., Kowluru A., et al. PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine. Am J Physiol Regul Integr Comp Physiol 2010, 299(6):R1610-017.
Eudy J.D., Spiegelstein O., et al. Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes. Mol Genet Metab 2000, 71(4):581-590.
Fleming J.C., Tartaglini E., et al. Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2. Mol Genet Metab 2003, 80(1-2):234-241.
Flood D.G., Zuvich E., et al. The effects of d-amphetamine, methylphenidate, sydnocarb, and caffeine on prepulse inhibition of the startle reflex in DBA/2 mice. Psychopharmacology (Berl) 2010, 211(3):325-336.
Frédérich M., Delvaux D., et al. Thiaminylated adenine nucleotides. FEBS J 2009, 276(12):3256-3268.
Fujiwara M. Absorption, excretion and fate of thiamine and its derivatives in human body. Review of Japanese literature on beriberi and thiamine 1965, 179-213. Vitamin B Research Committee of Japan, Kyoto. N. Shimazono, E. Katsura (Eds.).
Gibson G.E., Blass J.P. Thiamine-dependent processes and treatment strategies in neurodegeneration. Antioxid Redox Signal 2007, 9(10):1605-1619.
Gloire G., Legrand-Poels S., et al. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 2006, 72(11):1493-1505.
Golub M.S., Germann S.L., et al. Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse. Behav Brain Res 2004, 153(1):159-170.
Granon S., Faure P., et al. Executive and social behaviors under nicotinic receptor regulation. Proc Natl Acad Sci U S A 2003, 100(16):9596-9601.
Grillon C. Models and mechanisms of anxiety: evidence from startle studies. Psychopharmacology (Berl) 2008, 199(3):421-437.
Hammes H.P., Du X., et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med 2003, 9(3):294-299.
Houzen H., Kanno M. Thiamine and its derivatives inhibit delayed rectifier potassium channels of rat cultured cortical neurons. Neuropharmacology 1998, 37(3):313-322.
Inouye K., Katsura E. Clinical signs and metabolism of beriberi patients. Review of Japanese literature on beriberi and thiamine 1965, 29-63. Vitamin B Research Committee of Japan, Kyoto. N. Shimazono, E. Katsura (Eds.).
Itokawa Y. Thiamine and nervous system function: an historical sketch. Metab Brain Dis 1996, 11(1):1-7.
Institute of Medicine (U.S.). Standing Committee on the Scientific Evaluation of Dietary Reference Intakes., Institute of Medicine (U.S.). Panel on Folate Other B Vitamins and Choline., Institute of Medicine (U.S.). Subcommittee on Upper Reference Levels of Nutrients. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, D.C.: National Academy Press; 1998.
Johnson K.R., Longo-Guess C., et al. A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice. Genomics 2008, 92(4):219-225.
Jones D.N. Detoxification and protective functions of nutrients. Biochemical and physiological aspects of human nutrition 2000, 901-916. W.B. Saunders Company, Philadelphia. M.H. Stipanuk (Ed.).
Karachalias N., Babaei-Jadidi R., et al. Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes. Diabetologia 2010, 53(7):1506-1516.
Kwik-Uribe C.L., Golub M.S., et al. Chronic marginal iron intakes during early development in mice alter brain iron concentrations and behavior despite postnatal iron supplementation. J Nutr 2000, 130(8):2040-2048.
Lazareno S., Dolezal V., et al. Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol Pharmacol 2004, 65(1):257-266.
Lonsdale D. Effect of thiamine tetrahydrofurfuryl disulfide on audiogenic seizures in DBA/2J mice. Dev Pharmacol Ther 1982, 4(1-2):28-36.
Lonsdale D. Functional dysautonomia and nutrition. J Am Coll Nutr 1982, 1(1):125-125.
Lonsdale D. The effect of thiamine tetrahydrofurfuryl disulfide (TTFD) on blood-pressure in spontaneously hypertensive rats (SHR). J Am Coll Nutr 1987, 6(1):79-79.
Lonsdale D. A nutritionist's guide to the clinical use of vitamin B-1 1987, Life Sciences Press, Tacoma.
Lonsdale D. Hypothesis and case reports: possible thiamin deficiency. J Am Coll Nutr 1990, 9(1):13-17.
Lonsdale D. Sudden infant death syndrome requires genetic predisposition, some form of stress and marginal malnutrition. Med Hypotheses 2001, 57(3):382-386.
Lonsdale D. Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent. Med Sci Monit 2004, 10(9):RA199-RA203.
Lonsdale D. Review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives. Evid Based Complement Alternat Med 2006, 3(1):49-59.
Lonsdale D. Dysautonomia, a heuristic approach to a revised model for etiology of disease. Evid Based Complement Alternat Med 2009, 6(1):3-10.
Lonsdale D., Nodar R.H., et al. Brainstem dysfunction in infants responsive to thiamine disulfide: preliminary studies in four patients. Clin Electroencephalogr 1982, 13(2):82-88.
Lonsdale D., Shamberger R.J., et al. Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study. Neuro Endocrinol Lett 2002, 23(4):303-308.
Loo H., Poirier M.F., et al. Effects of sulbutiamine (Arcalion 200) on psycho-behavioral inhibition in major depressive episodes. Encéphale 2000, 26(2):70-75.
Marini N.J., Gin J., et al. The prevalence of folate-remedial MTHFR enzyme variants in humans. Proc Natl Acad Sci U S A 2008, 105(23):8055-8060.
Matsui K., Nakahara H., et al. Inhibition by thiamine tetrahydrofurfuryl disulfide (TTFD) of the arachidonic acid cascade-line activation as evidenced in the heart-lung preparation of the dog. Jpn J Pharmacol 1985, 39(3):375-379.
McCaughran J., Bell J., et al. On the relationships of high-frequency hearing loss and cochlear pathology to the acoustic startle response (ASR) and prepulse inhibition of the ASR in the BXD recombinant inbred series. Behav Genet 1999, 29(1):21-30.
McCaughran J., Mahjubi E., et al. Genetics, haloperidol-induced catalepsy and haloperidol-induced changes in acoustic startle and prepulse inhibition. Psychopharmacology (Berl) 1997, 134(2):131-139.
McCaughran J.A., Bell J., et al. Fear-potentiated startle response in mice: genetic analysis of the C57BL/6J and DBA/2J intercross. Pharmacol Biochem Behav 2000, 65(2):301-312.
McCormick D.B. Niacin, riboflavin, and thiamin. Biochemical and physiological aspects of human nutrition 2000, 458-482. W.B. Saunders Company, Philadelphia. M.H. Stipanuk (Ed.).
McGrane M.M. Carbohydrate metabolism-synthesis and oxidation. Biochemical and physiological aspects of human nutrition 2000, 158-210. W.B. Saunders Company, Philadelphia. M.H. Stipanuk (Ed.).
Meador K.J., Nichols M.E., et al. Evidence for a central cholinergic effect of high-dose thiamine. Ann Neurol 1993, 34(5):724-726.
Micheau J., Durkin T.P., et al. Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. Pharmacol Biochem Behav 1985, 23(2):195-198.
Mimori Y., Katsuoka H., et al. Thiamine therapy in Alzheimer's disease. Metab Brain Dis 1996, 11(1):89-94.
Mitoma C. Metabolic disposition of thiamine tetrahydrofurfuryl disulfide in dog and man. Drug Metab Dispos 1973, 1(5):698-703.
Mizutani M., Ihara T., et al. Effect of thiamine tetrahydrofurfuryl disulfide upon developing fetuses of mice and rats. J Takeda Res Lab 1971, 30(1):131-137.
Mizutani M., Ihara T., et al. Effects of orally administered thiamine tetrahydrofurfuryl disulfide on foetal development of rabbits and monkeys. Jpn J Pharmacol 1972, 22(1):115-124.
Moy S.S., Nadler J.J., et al. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 2007, 176(1):4-20.
Nakagawasai O., Tadano T., et al. Involvement of muscarinic receptor on the impairment of avoidance learning in mice fed a thiamine-deficient diet. Biog Amines 2001, 16(2):199-210.
Nakagawasai O., Tadano T., et al. Immunohistochemical estimation of rat brain somatostatin on avoidance learning impairment induced by thiamine deficiency. Brain Res Bull 2000, 51(1):47-55.
Nakagawasai O., Yamadera F., et al. Preventive effect of Kami-Untan-To on performance in the forced swimming test in thiamine-deficient mice: relationship to functions of catecholaminergic neurons. Behav Brain Res 2007, 177(2):315-321.
Nakagawasai O., Yamadera F., et al. Effect of Kami-Untan-To on the impairment of learning and memory induced by thiamine-deficient feeding in mice. Neuroscience 2004, 125(1):233-241.
National Research Council (U.S.). Subcommittee on Laboratory Animal Nutrition. Nutrient requirements of laboratory animals. 4th rev. ed. Washington, D.C.: National Academy of Sciences; 1995.
Nozaki S., Mizuma H., et al. Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats. Nutr Res 2009, 29(12):867-872.
Oi Y., Shishido C., et al. Allylthiamindisulfide and related compounds enhance thermogenesis with increasing noradrenaline and adrenaline secretion in rats. J Nutr Sci Vitaminol (Tokyo) 1999, 45(5):643-653.
Olivier B., Leahy C., et al. The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics?. Psychopharmacology (Berl) 2001, 156(2-3):284-290.
Pan X., Gong N., et al. Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain 2010, 133(Pt 5):1342-1351.
Panksepp J.B., Lahvis G.P. Social reward among juvenile mice. Genes Brain Behav 2007, 6(7):661-671.
Paylor R., Crawley J.N. Inbred strain differences in prepulse inhibition of the mouse startle response. Psychopharmacology (Berl) 1997, 132(2):169-180.
Pekovich S.R., Martin P.R., et al. Thiamine deficiency decreases steady-state transketolase and pyruvate dehydrogenase but not alpha-ketoglutarate dehydrogenase mRNA levels in three human cell types. J Nutr 1998, 128(4):683-687.
Pekovich S.R., Poggi V., et al. Sensitivity to thiamine deficiency in cultured human cells is dependent on cell type and is enhanced in cells from thiamine-responsive megaloblastic anemia patients. J Nutr Biochem 1998, 9(4):215-222.
Peskin M.R., Newton G., et al. Thiamine deficiency, infantile manipulation and startle response in rats. J Nutr 1967, 91(1):20-24.
Reddy S.Y., Pullakhandam R., et al. Thiamine reduces tissue lead levels in rats: mechanism of interaction. Biometals 2010, 23(2):247-253.
Rosenwasser A.M. Functional neuroanatomy of sleep and circadian rhythms. Brain Res Rev 2009, 61(2):281-306.
Salminen A., Kaarniranta K. Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process. J Cell Physiol 2010, 224(1):1-6.
Semenova S., Bespalov A., et al. Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration. Eur J Pharmacol 2003, 472(1-2):99-110.
Shah S.N. Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia. J Assoc Physicians India 2003, 51:891-895.
Sheline C.T., Wei L. Free radical-mediated neurotoxicity may be caused by inhibition of mitochondrial dehydrogenases in vitro and in vivo. Neuroscience 2006, 140(1):235-246.
Review of Japanese literature on beriberi and thiamine 1965, Vitamin B Research Committee of Japan, Kyoto. N. Shimazono, E. Katsura (Eds.).
Spiegel R., Shaag A., et al. SLC25A19 mutation as a cause of neuropathy and bilateral striatal necrosis. Ann Neurol 2009, 66(3):419-424.
Stevens K.E., Adams C.E., et al. Permanent improvement in deficient sensory inhibition in DBA/2 mice with increased perinatal choline. Psychopharmacology (Berl) 2008, 198(3):413-420.
Suzuoki Z., Tominaga F., et al. Metabolism of thiamine and thiamine tetrahydro-furfuryl disulfide to 4-methylthiazole-5-acetic acid in conventional and germfree rats under various dosing conditions. J Nutr 1968, 96(4):433-444.
Swerdlow N.R., Weber M., et al. Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology 2008, 199(3):331-388.
Tallaksen C.M.E., Tauboll E. Excitatory effect of thiamin on CA1 pyramidal neurones in rat hippocampal slices in vitro. Eur J Neurol 2000, 7(6):693-698.
Terranova M.L., Laviola G. delta-Opioid modulation of social interactions in juvenile mice weaned at different ages. Physiol Behav 2001, 73(3):393-400.
Thomson A.D., Marshall E.J. The natural history and pathophysiology of Wernicke's encephalopathy and Korsakoff's psychosis. Alcohol Alcohol 2006, 41(2):151-158.
Toliver-Kinsky T., Wood T., et al. Nuclear factor kappaB/p49 is a negative regulatory factor in nerve growth factor-induced choline acetyltransferase promoter activity in PC12 cells. J Neurochem 2000, 75(6):2241-2251.
Turner J., Hughes L.F., et al. Sleep, activity, temperature and arousal responses of mice deficient for muscarinic receptor M2 or M4. Life Sci 2010, 86(5-6):158-169.
Van Reeth O. Pharmacologic and therapeutic features of sulbutiamine. Drugs Today (Barc) 1999, 35(3):187-192.
Verma S., Reddy K., et al. The defensive effect of benfotiamine in sodium arsenite-induced experimental vascular endothelial dysfunction. Biol Trace Elem Res 2010, 137(1):96-109.
Wilkinson T.J., Hanger H.C., et al. The response to treatment of subclinical thiamine deficiency in the elderly. Am J Clin Nutr 1997, 66(4):925-928.
Woelk H., Lehrl S., et al. Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study (BAP I Study). Alcohol Alcohol 1998, 33(6):631-638.
Yadav U.C., Kalariya N.M., et al. Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages. Free Radic Biol Med 2010, 48(10):1423-1434.
Yamashita H., Zhang Y.X., et al. The effects of thiamin and its phosphate esters on dopamine release in the rat striatum. Neurosci Lett 1993, 158(2):229-231.
