Article (Scientific journals)
Vascularity and fractal dimension of the dermo-epidermal interface in guttate and plaque-type psoriasis.
Uhoda, Isabelle; Pierard, Gérald; Pierard-Franchimont, Claudine et al.
2005In Dermatology, 210 (3), p. 189-93
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Keywords :
Biopsy; Case-Control Studies; Humans; Microcirculation; Neovascularization, Pathologic/pathology/physiopathology; Psoriasis/pathology/physiopathology; Skin/blood supply
Abstract :
[en] BACKGROUND: Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions. OBJECTIVE: To determine and compare the variations in shape of the dermo-epidermal junction and the size of the superficial vessels in psoriatic lesions. METHOD: The relative microvasculature area and the fractal dimension D of the dermo-epidermal interface were measured inside and outside growth-stunted guttate lesions (n = 22) and expanding plaques (n = 37) in psoriasis of the trunk. RESULTS: The median D values of the dermo-epidermal interface were significantly larger (p < 0.01) in psoriatic plaques (D = 1.15) than in guttate lesions (D = 1.08), and these D values on lesional skin were significantly larger (p < 0.01) than in the uninvolved skin (D = 1.03). The microvasculature was significantly (p < 0.01) more developed in lesional (plaque: 13%, guttate: 8.20%) than in uninvolved skin (3.60 and 3.85%). No correlations were found between the relative microvasculature areas and the D values of the dermo-epidermal interface, both in the uninvolved and lesional skins of each psoriatic type. CONCLUSION: The absence of a relationship between modulations of the dermo-epidermal junction and vascular hyperplasia, both in expanding and stable psoriasis lesions, suggests that these events are regulated by different mechanisms and do not depend on each other.
Disciplines :
Dermatology
Author, co-author :
Uhoda, Isabelle
Pierard, Gérald ;  Université de Liège - ULiège > Dermatopathologie
Pierard-Franchimont, Claudine ;  Université de Liège - ULiège > Dermatopathologie
Arrese Estrada, Jorge ;  Université de Liège - ULiège > Dermatopathologie
Goffin, Véronique ;  Université de Liège - ULiège > Dermatopathologie
Nikkels, Arjen ;  Université de Liège - ULiège > Dermatologie
Paquet, Philippe ;  Université de Liège - ULiège > Dermatopathologie
Quatresooz, Pascale  ;  Université de Liège - ULiège > Dermatopathologie
Language :
English
Title :
Vascularity and fractal dimension of the dermo-epidermal interface in guttate and plaque-type psoriasis.
Publication date :
2005
Journal title :
Dermatology
ISSN :
1018-8665
eISSN :
1421-9832
Publisher :
S. Karger, Basel, Switzerland
Volume :
210
Issue :
3
Pages :
189-93
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 March 2009

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