[en] BACKGROUND: Histological structures of the skin are often irregular in size and shape. Euclidean geometry and fractal analysis are complementary for assessing distinct aspects of their dimensions. OBJECTIVE: To determine and compare the variations in shape of the dermo-epidermal junction and the size of the superficial vessels in psoriatic lesions. METHOD: The relative microvasculature area and the fractal dimension D of the dermo-epidermal interface were measured inside and outside growth-stunted guttate lesions (n = 22) and expanding plaques (n = 37) in psoriasis of the trunk. RESULTS: The median D values of the dermo-epidermal interface were significantly larger (p < 0.01) in psoriatic plaques (D = 1.15) than in guttate lesions (D = 1.08), and these D values on lesional skin were significantly larger (p < 0.01) than in the uninvolved skin (D = 1.03). The microvasculature was significantly (p < 0.01) more developed in lesional (plaque: 13%, guttate: 8.20%) than in uninvolved skin (3.60 and 3.85%). No correlations were found between the relative microvasculature areas and the D values of the dermo-epidermal interface, both in the uninvolved and lesional skins of each psoriatic type. CONCLUSION: The absence of a relationship between modulations of the dermo-epidermal junction and vascular hyperplasia, both in expanding and stable psoriasis lesions, suggests that these events are regulated by different mechanisms and do not depend on each other.
Disciplines :
Dermatology
Author, co-author :
Uhoda, Isabelle
Pierard, Gérald ; Université de Liège - ULiège > Dermatopathologie
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Bibliography
Cross SS, Cotton DWK: The fractal dimension may be a useful morphometric discriminant in histopathology. J Pathol 1992;166:409-411.
Ragaz A, Ackerman AB: Evolution, maturation, and regression of lesions of psoriasis: New observations and correlation of clinical and histologic findings. Am J Dermatopathol 1979;1:199-214.
Piérard GE, Piérard-Franchimont C: Formation de l'hyperplasie dermo-épidermique dans le psoriasis. Ann Dermatol Vénéréol 1983;110: 891-897.
Mordovtsev VN, Albanova VI: Morphology of skin microvasculature in psoriasis. Am J Dermatopathol 1989;11:33-42.
Lowe PM, Lee ML, Jackson CJ, To SS, Cooper AJ, Schrieber L: The endothelium in psoriasis. Br J Dermatol 1995;132:497-505.
Hern S, Stanton AW, Mellor R, Levick TR, Mortimer PS: Control of cutaneous blood vessels in psoriatic plaques. J Invest Dermatol 1999;113:127-132.
Piérard GE, Piérard-Franchimont C, Lapière ChM: Proliferation and hyperplasia of vascular endothelium in human skin. Am J Dermatopathol 1985;7:477-488.
Creamer D, Allen MH, Sousa A, Poston R, Barker JN: Localization of endothelial proliferation and microvascular expansion in active plaque psoriasis. Br J Dermatol 1997;136:859-865.
De Angelis R, Bugatti L, Del Medico P, Nicolini M, Filosa G: Videocapillaroscopic findings in the microcirculation of the psoriatic plaque. Dermatology 2002;204:236-239.
Malhotra R, Stenn KS, Fernandez LA, Braverman IM: Angiogenic properties of normal and psoriatic skin associate with epidermis, not dermis. Lab Invest 1989;61:162-165.
Wolf JE: Angiogenesis in normal and psoriatic skin. Lab Invest 1989;61:139-142.
Creamer JD, Barker JNWN: Vascular proliferation and angiogenic factors in psoriasis. Clin Exp Dermatol 1995;20:6-9.
Bacharach-Buhles M, El Gammal S, Panz B, Altmeyer P: The pseudo-elongation of capillaries in psoriatic plaques. Acta Derm Venereol 1994;suppl 186:133-137.
Khan A, Schall LM, Tur E, Maibach HI, Guy RH: Blood flow in psoriatic skin lesions: The effect of treatment. Br J Dermatol 1987;117: 193-201.
Hull SM, Goodfield M, Wood EJ, Cunliffe WJ: Active and inactive edges of psoriatic plaques: Identification by tracing and investigation by laser-Doppler flowmetry and immunocytochemical techniques. J Invest Dermatol 1989; 92:782-785.
Parent D, Bernard BA, Desbas C, Heenen M, Darmon MY: Spreading of psoriatic plaques: Alteration of epidermal differentiation precedes capillary leakiness and anomalies in vascular morphology. J Invest Dermatol 1990;95: 333-340.
Barton SP, Abdullah MS, Marks R: Quantification of microvascular changes in the skin in patients with psoriasis. Br J Dermatol 1992; 126:569-574.
Bull RH, Bates DO, Mortimer PS: Intravital video-capillaroscopy for the study of the microcirculation in psoriasis. Br J Dermatol 1992; 126:436-445.
Goodfield M, Hull SM, Holland D, Roberts G, Wood E, Reid S, Cunliffe W: Investigations of the 'active' edge of plaque psoriasis: Vascular proliferation precedes changes in epidermal keratin. Br J Dermatol 1994;131:808-813.
Vico PG, Boyer H, Cartilier LH: New concepts in the study of tissue vascularization: A mathematical model of skin vascularization. Plast Reconstr Surg 1994;94:174-179.
Goldberger AL: Non-linear dynamics for clinicians: Chaos theory, fractals, and complexity at the bedside. Lancet 1996;347:1312-1313.
Losa GA, Nonnenmacher TF: Self-similarity and fractal irregularity in pathological tissues. Mod Pathol 1996;9:174-182.
Heymans O, Blacher S, Brouers F, Piérard GE: Fractal quantification of the heterogeneity in cutaneous melanoma. Dermatology 1999;198: 212-217.
Arrese JE, Fogouang L, Piérard-Franchimont C, Piérard GE: Euclidean and fractal computer-assisted corneofungimetry: A comparison of 2% ketoconazole and 1% terbinafine topical formulations. Dermatology 2002;204:222-227.
Robert C, Kupper TS: Inflammatory skin diseases, T cells, and immune surveillance. N Engl J Med 1999;341:1817-1828.
Prinz JC: Psoriasis vulgaris - A sterile antibacterial skin reaction mediated by cross-reactive T cells? An immunological view of the pathophysiology of psoriasis. Clin Exp Dermatol 2001;26:326-332.
Detmar M, Brown LF, Claffey KP, Yeo KT, Kocher O, Jackman RW, Berse B, Dvorak HF: Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med 1994;180: 1141-1146.
de la Brassinne M, Piérard GE: Interprétation pathogénique de l'extension des placards de psoriasis: analyse histogéométrique et étude autoradiographique. Dermatologica 1973;147: 161-173.
Piérard GE, Piérard-Franchimont C, de la Brassinne M: Impetigo herpetiformis and pustular psoriasis during pregnancy. Am J Dermatopathol 1983;22:300-304.
Piérard-Franchimont C, Piérard GE: Stereotyped distribution of proliferating keratinocytes in disorders affecting the epidermis. Am J Dermatopathol 1989;11:233-237.
True LD: Morphometric applications in anatomic pathology. Hum Pathol 1996;27:450-467.
Claridge E, Hall PN, Keefe M, Allen JP: Shape analysis for classification of malignant melanoma. J Biomed Eng 1992;14:229-234.
Cross SS: The application of fractal geometric analysis to microscopic images. Micron 1994;25:101-113.
Buczkowski S, Kyriacos S, Nekka F, Cartilier LH: Some guidelines for estimating fractal dimension with a box-counting method in image analysis. Patt Recog 1998;31:411-418.
Vico PG, Kyriacos S, Heymans O, Louryan S, Cartilier L: Dynamic study of the extra embryonic vascular network of the chick embryo by fractal analysis. J Theor Biol 1998;195:525-532.
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