L'activité antibiotique du type actinomycetine chez les Streptomyces

cf. C.A. 47, 6491c; 49, 422d. Actinomycetin, obtained from Streptomyces albus G, was shown to contain 5 distinct enzymes which attack, resp., heat-killed Escherichia coli, keratin, mucin, casein, and a component of the epidermis the destruction of which results in epidermal desquamation and loosening of the hair. The substrate of this last enzyme is a complex protein component of the skin extractable by urea soln. (with or without KCl) at 25°. Another fraction of the epidermis, extractable under similar conditions at 0°, appears to be sensitive to the keratinolytic enzyme. [on SciFinder(R)]