Reference : Cytokine serum level during severe sepsis in human Il-6 as a marker of severity
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
http://hdl.handle.net/2268/9636
Cytokine serum level during severe sepsis in human Il-6 as a marker of severity
English
Damas, Pierre mailto [Université de Liège - ULiège > > Soins intensifs >]
Ledoux, Didier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Nys, Monique mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Vrindts, Yvonne [> > > >]
De Groote, Donat [> > > >]
Franchimont, Paul [> > > >]
Lamy, Maurice mailto [Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation]
Apr-1992
Annals of Surgery
215
4
356-362
Yes (verified by ORBi)
International
0003-4932
[en] Forty critically ill surgical patients with documented infections were studied during their stay in an intensive care unit. Among these patients, 19 developed septic shock and 16 died, 9 of them from septic shock. Interleukin 1 beta (IL-1 beta), tumor necrosis factor (TNF alpha), and interleukin 6 (IL-6) were measured each day and every 1 or 2 hours when septic shock occurred. Although IL-1 beta was never found, TNF alpha was most often observed in the serum at a level under 100 pg/mL except during septic shock. During these acute episodes TNF alpha level reached several hundred pg/mL, but only for a few hours. In contrast, IL-6 was always increased in the serum of acutely ill patients (peak to 500,000 pg/mL). There was a direct correlation between IL-6 peak serum level and TNF alpha peak serum level during septic shock and between IL-6 serum level and temperature or C-reactive protein serum level. Moreover, IL-6 correlated well with APACHE II score, and the mortality rate increased significantly in the group of patients who presented with IL-6 serum level above 1000 pg/mL. Thus, IL-6 appears to be a good marker of severity during bacterial infection.
Researchers ; Professionals
http://hdl.handle.net/2268/9636
10.1097/00000658-199204000-00009

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