Article (Scientific journals)
Sepsis and Serum Cytokine Concentrations
Damas, Pierre; Canivet, Jean-Luc; de Groote, Donat et al.
1997In Critical Care Medicine, 25 (3), p. 405-12
Peer Reviewed verified by ORBi
 

Files


Full Text
293.pdf
Publisher postprint (1.02 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
severe sepsis; septic shock; interleukin-6; interleukin-8; tumor necrosis factor-alpha; leukemia inhibitory factor; cytokines
Abstract :
[en] OBJECTIVE: To look for relationships between the classification of sepsis and plasma cytokine concentrations. DESIGN: Prospective, consecutive entry study of patients meeting severe sepsis criteria and having bacteriologically documented infections. SETTING: University hospital, surgical intensive care unit. PATIENTS: Fifty consecutive patients developing severe sepsis or septic shock between December 1991 and December 1993. MEASUREMENTS AND MAIN RESULTS: Concentrations of tumor necrosis factor, interleukin (IL)-6, IL-8, and leukemia inhibitory factor were measured by immunoradiometric assay in the plasma of patients as soon as they developed severe sepsis or septic shock. Septic shock patients were divided into three groups in a blinded fashion (i.e., without knowing the results of the concentrations of cytokines), according to the presence of sustained hyperlactacidemia and to the rapidity of the onset of sepsis. Peak concentrations of all cytokines were statistically different between severe sepsis and septic shock patients. This finding was almost exclusively due to the data from patients with rapid onset of septic shock, who demonstrated very high but transient cytokine concentrations. Septic shock patients may thus have different profiles in the time course of their cytokine concentrations. The transient, high peak concentrations of cytokines were also related to transient leukopenia. Among the cytokines measured, IL-8 appeared to be the one that correlated best with lactacidemia, the presence of disseminated intravascular coagulation, severe hypoxemia, the Acute Physiology and Chronic Health Evaluation II score, and mortality rate. CONCLUSIONS: According to the profiles of the cytokines, septic shock patients do not represent a homogeneous population. These profiles should be described in order to distinguish between patients, and the profiles may be useful to identify those patients susceptible to new therapies.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Damas, Pierre ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Canivet, Jean-Luc ;  Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
de Groote, Donat
Vrindts, Yvonne
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Franchimont, Paul
Lamy, Maurice ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Language :
English
Title :
Sepsis and Serum Cytokine Concentrations
Publication date :
March 1997
Journal title :
Critical Care Medicine
ISSN :
0090-3493
eISSN :
1530-0293
Publisher :
Lippincott Williams & Wilkins, United States - Pennsylvania
Volume :
25
Issue :
3
Pages :
405-12
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 March 2009

Statistics


Number of views
66 (4 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
206
Scopus citations®
without self-citations
206
OpenCitations
 
166

Bibliography


Similar publications



Contact ORBi