Reference : Inhibition of testosterone metabolism in the brain and cloacal gland of the quail by ...
Scientific journals : Article
Life sciences : Zoology
Social & behavioral sciences, psychology : Neurosciences & behavior
Inhibition of testosterone metabolism in the brain and cloacal gland of the quail by specific inhibitors and antihormones.
Alexandre, Corine [ > > ]
Balthazart, Jacques mailto [ > > ]
Journal of Endocrinology
Society for Endocrinology
Yes (verified by ORBi)
United Kingdom
[en] Androgen Antagonists/pharmacology ; Androstanes/pharmacology ; Androstatrienes/pharmacology ; Animals ; Azasteroids/pharmacology ; Cloaca/drug effects/metabolism ; Coturnix/physiology ; Cyproterone/analogs & derivatives/pharmacology ; Cyproterone Acetate ; Estrogen Antagonists/pharmacology ; Flutamide/pharmacology ; Hypothalamus/drug effects/metabolism ; Male ; Nitromifene/pharmacology ; Quail/physiology ; Tamoxifen/pharmacology ; Testosterone/metabolism/pharmacology
[en] The effects of antioestrogens, antiandrogens and of various inhibitors of testosterone metabolism on testosterone metabolism in the quail hypothalamus and cloacal gland were studied by an in-vitro radioenzymatic assay. It was found that antioestrogens and antiandrogens generally had little or no effect on aromatase and 5 alpha- and 5 beta-reductases of testosterone, except when used at very high doses. The 5 alpha-reductase inhibitor, 17 beta-N,N-diethylcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one, inhibited both 5 alpha- and 5 beta-dihydrotestosterone production without markedly affecting aromatase activity. Surprisingly, the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, inhibited not only the production of oestradiol but also that of 5 beta-dihydrotestosterone and, to a lesser extent, 5 alpha-dihydrotestosterone. These unexpected properties should be taken into account when interpreting the results of in-vivo experiments using these compounds.

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