Article (Scientific journals)
Stress-induced decreases in local cerebral glucose utilization in specific regions of the mouse brain.
Warnock, Geoffrey; Steckler, Thomas
2011In BMC Research Notes, 4, p. 96
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Abstract :
[en] BACKGROUND: Restraint stress in rodents has been reported to activate the hypothalamic-pituitary-adrenocortical (HPA) axis and to increase c-fos expression in regions that express components of the corticotropin-releasing factor (CRF) system. We have previously reported that acute central administration of CRF increased a measure of relative local cerebral glucose utilization (LCGU), a measure of neuronal activity in specific brain regions, and activated the HPA axis in mice. It was hypothesized that the involvement of the CRF system in the stress response would lead to similar changes in relative LCGU after restraint stress. In the present studies the effect of restraint stress on relative LCGU and on the HPA axis in C57BL/6N mice were examined. FINDINGS: Restraint stress activated the HPA axis in a restraint-duration dependent manner, but in contrast to the reported effects of CRF, significantly decreased relative LCGU in frontal cortical, thalamic, hippocampal and temporal dissected regions. These findings support evidence that stressors enforcing limited physical activity reduce relative LCGU, in contrast to high activity stressors such as swim stress. CONCLUSIONS: In conclusion, the present studies do not support the hypothesis that stress-induced changes in relative LCGU are largely mediated by the CRF system. Further studies will help to delineate the role of the CRF system in the early phases of the relative LCGU response to stress and investigate the role of other neurotransmitter systems in this response.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Warnock, Geoffrey ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Steckler, Thomas;  Johnson & Johnson PRD (Beerse, Belgium) > Department of Psychiatry
Language :
English
Title :
Stress-induced decreases in local cerebral glucose utilization in specific regions of the mouse brain.
Publication date :
2011
Journal title :
BMC Research Notes
eISSN :
1756-0500
Publisher :
BioMed Central, London, United Kingdom
Volume :
4
Pages :
96
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 July 2011

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