Reference : In vivo studies on the mononuclear phagocyte system Fc receptor function in rheumatoi...
Scientific journals : Article
Human health sciences : Rheumatology
http://hdl.handle.net/2268/94629
In vivo studies on the mononuclear phagocyte system Fc receptor function in rheumatoid arthritis. Correlations with clinical and immunological variables
English
Malaise, Michel mailto [Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie >]
Foidart, J. B. [ > > ]
Hauwaert, Christian [Université de Liège - ULiège > > Rhumatologie >]
Mahieu, P. [ > > ]
Franchimont, P. [ > > ]
1985
Journal of Rheumatology
Journal of Rheumatology Publishing Company
12
1
33-42
Yes (verified by ORBi)
International
0315-162X
Toronto
Canada
[en] RHEUMATOID ARTHRITIS ; MONONUCLEAR PHAGOCYTE SYSTEM ; Fc RECEPTOR FUNCTION ; SPLEEN TO LIVER RATIO
[en] The mononuclear phagocyte system Fc receptor function was assessed in 13 control subjects and 17 patients with rheumatoid arthritis (RA) by intravenous injection of IgG coated (IgG-RBC) or of heat-damaged (HD-RBC) 99rnTc-Iabeled autologous erythrocytes. Although the clearance half-times of control and RA erythrocytes were not significantly different, the spleen to liver uptake ratios per surface area (S/Ls), determined by quantitative scintigraphic analysis, were significantly lower in RA patients than in controls. The S/Lswere significantly correlated with the Steinbrocker stages Ir = 0.92; p < 0.01), the disease duration (r = 0.73; p < 0.01) and the total immunoglobulin levels (r = 0.73; p < 0.01). The Clq binding activity of the sera was inversely correlated with the spleen (r = 0.90; p < 0.01) and liver uptakes (r = 0.73; p < 0.02). Our results therefore show an alteration of the Fc receptor function of splenic and hepatic mononuclear phagocytes in RA patients.
Researchers ; Professionals
http://hdl.handle.net/2268/94629

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