Drug Combinations; Immunoglobulin G; Immunoglobulins, Intravenous; Pregnancy Proteins; gamma-Globulins; Fibrinolysin
Abstract :
[en] A double-blind multicenter study comparing the effect of placenta eluted IgG and
venoglobulins in the treatment of rheumatoid arthritis was conducted in 113
hospitalized patients. Rheumatoid arthritis was severe, classical (92 cases) or
definite (21 cases), seropositive in 87 cases, with nodules in 32 cases; the mean
duration of the disease was 10 years. The majority of patients had previously
received numerous slow-acting drugs without result or with side-effects. A
statistically significant decrease of all the quantitative indices but one (grip
strength) was obtained with both products on the 8th day of treatment; the effect
of placenta eluted IgG was statistically superior for the number of swollen
joints (P less than 0.025), Ritchie's index (P less than 0.0005) and some
extra-articular manifestations. There was no significant decrease in associated
treatments and biological parameters (erythrocyte sedimentation rate, rheumatoid
factor). Tolerance was excellent; some cases of benign venulitis were observed;
treatment was never discontinued on account of side-effects. Further
placebo-controlled of each of these immunoglobulins of placental origin are
needed for firm conclusions to be drawn.
Disciplines :
Rheumatology
Author, co-author :
Sany, J.
Clot, J.
Combe, B.
Franchimont, P.
Malaise, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
