Reference : In vitro effects of thymopentin on the gamma-interferon production by peripheral bloo...
Scientific journals : Article
Human health sciences : Rheumatology
In vitro effects of thymopentin on the gamma-interferon production by peripheral blood mononuclear cells from normal subjects and from patients with rheumatoid arthritis
Malaise, Michel mailto [Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie >]
Bastings, M. [ > > ]
Reuter, A. M. [ > > ]
Vrindts-Gevaert, Y. [ > > ]
Bernier, J. [ > > ]
Sondag, D. [ > > ]
Frere, M. C. [ > > ]
Goldstein, G. [ > > ]
Franchimont, P. [ > > ]
Immunology Letters
Elsevier Science
Yes (verified by ORBi)
[en] Peptide Fragments ; Thymopoietins ; Thymus Hormones ; Interferon-gamma ; Arthritis, Rheumatoid
[en] The in vitro production of gamma-interferon (gamma-IFN) by peripheral blood
mononuclear cells (MNC) was measured using a specific radioimmunoassay in 16
patients presenting with active rheumatoid arthritis (RA), in 14 patients with
inactive disease, and in 36 control subjects (CS). Unstimulated cultures produced
undetectable levels of gamma-IFN and did not incorporate tritiated thymidine. In
response to phytohemagglutinin (PHA) 0.2 microgram/ml, MNC from active RA
produced 9 times less, and under PHA 2.5 micrograms/ml, 4 times less gamma-IFN
than did MNC from inactive RA or from CS. The uptake of tritiated thymidine was,
however, similar in the 3 groups. In unstimulated cultures of the 3 groups,
thymopentin (TP-5), at all concentrations tested, did not influence either the
levels of gamma-IFN or the uptake of tritiated thymidine. In the presence of PHA
0.2 microgram/ml and TP-5, lambda-IFN levels were increased in CS, unchanged in
inactive RA and reduced in active RA, whereas no changes were observed in the
uptake of tritiated thymidine. Our results show that under our experimental
conditions, TP-5 was able to increase the levels of gamma-IFN produced by normal
MNC in vitro, but could not reverse the profound defect observed in active RA.
Researchers ; Professionals

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