Increased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies
Ribbens, Clio; Andre, Béatrice; Kaye, O.et al.
2000 • In European Cytokine Network, 11 (4), p. 669-676
CD Antigens; Cytokines; Tumor Necrosis Factor; Interleukin-2; Interleukin-10; Interleukin-12
Abstract :
[en] The assessment of cytokines and their soluble receptors in the synovial fluid
(SF) of inflammatory arthropathies may be useful in studying pathogenetic and
immunoregulatory mechanisms underlying different diseases. The aim of this work
was to study the cytokine network occurring in inflammatory arthropathies and to
identify a cytokine profile which is characteristic of an immune-mediated
synovitis. Levels of IL-12, as well as IL-4, IL-8, IL-10, IFN-gamma, sCD25,
TNF-alpha and its soluble receptors were measured in the SF of various
arthropathies, i.e. non-inflammatory arthropathies: "control" meniscus pathology
(n = 21), osteoarthritis (n = 22) and chronic crystal arthritis (n = 9); a
non-immune inflammatory arthropathy: acute crystal arthritis (n = 11); 2 immune
inflammatory arthropathies: reactive arthritis (ReA) (n = 23) and rheumatoid
arthritis (RA) (n = 44). SF levels of IL-10, TNF-alpha and sTNF-RII were found to
be increased in the three inflammatory arthropathies compared to the "control"
meniscus group. Within the inflammatory group, acute crystal arthritis was
characterized by a significantly higher sTNF-RI/TNF-alpha ratio and ReA by a
significantly lower sTNF-RII/TNF-alpha ratio compared to the two other diseases.
The two immune arthropathies, RA and ReA, were characterized by increased SF
levels of IL-12, sCD25 and of the sTNF-RII/sTNF-RI ratio. ReA differed however
from RA by showing lower IL-8 and IL-4 levels, higher IFN-gamma levels and a
higher IL-12/IL-10 ratio, suggesting a more prevalent Th1 profile in ReA SF. Our
data indicate that the measurement of SF cytokines and soluble receptors may
discriminate between each inflammatory arthropathy and might be useful in
clinical practice.
Disciplines :
Rheumatology
Author, co-author :
Ribbens, Clio ; Université de Liège - ULiège > Rhumatologie
Malaise, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
Language :
English
Title :
Increased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies
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