Gastrointestinal safety of amtolmetin guacyl in comparison with celecoxib in patients with rheumatoid arthritis

Jajic, Z.; Malaise, Michel; Nekam, K.; Koó, E.; Dankó, K.; Kovacs, M.; Scarpignato, C.

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Article (Scientific journals)

Gastrointestinal safety of amtolmetin guacyl in comparison with celecoxib in patients with rheumatoid arthritis

Jajic, Z.; Malaise, Michel; Nekam, K. et al.

2005 • In Clinical and Experimental Rheumatology, 2³3 (6), p. 809-818

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https://hdl.handle.net/2268/94564

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16396699

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Keywords :

NSAID; amtolmetin guacyl; celecoxib

Abstract :

[en] OBJECTIVES: Selective inhibitors of cyclo-oxygenase-2 (COX-2) appear to be safer than conventional NSAIDs on the gastrointestinal (GI) tract. Amtolmetin guacyl (AMG), a NSAID that inhibits both COX-1 and COX-2, has an anti-inflammatory effect comparable to that of traditional NSAIDs, with a better GI safety profile. The primary end-point of this study was to evaluate the gastrointestinal safety of amtolmetin guacyl in comparison with celecoxib in patients affected with rheumatoid arthritis. The assessment of efficacy was the secondary end-point.

Disciplines :

Rheumatology

Author, co-author :

Jajic, Z.

Malaise, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie

Nekam, K.

Koó, E.

Dankó, K.

Kovacs, M.

Scarpignato, C.

Language :

English

Title :

Gastrointestinal safety of amtolmetin guacyl in comparison with celecoxib in patients with rheumatoid arthritis

Publication date :

2005

Journal title :

Clinical and Experimental Rheumatology

ISSN :

0392-856X

eISSN :

1593-098X

Publisher :

Clinical and Experimental Rheumatology SAS, Pisa, Italy

Volume :

2³3

Issue :

Pages :

809-818

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 June 2011

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2 (2 by ULiège)

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