Keywords :
Administration, Topical; Betamethasone/administration & dosage/analogs & derivatives/therapeutic use; Calcitriol/administration & dosage/analogs & derivatives/therapeutic use; Drug Therapy, Combination; Humans; Inflammation; Psoriasis/drug therapy
Abstract :
[en] The topical treatment of psoriasis benefits from the alternate use of dermocorticosteroids and vitamin D3 analogues. A new galenic formulation allows to combine them in a single application. Dovobet (LEO Pharma) ointment is the association of calcipotriol 50 microg/g with betamethasone dipoprionate 0.5 mg/g. This formulation boosts the therapeutic activity of calcipotriol. It also decreases the irritative inflammatory reaction due to calcipotriol without increasing the atrophogenic risk of the dermocorticoid.
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