Early fetal loss; Progesterone supplementation; GnRH; Twins; Dairy cattle
Résumé :
[en] In order to explore pregnancy patterns in high producing dairy cows treated with GnRH or progesterone at pregnancy diagnosis (Days 28-34), two consecutive experiments were designed. In Experiment 1, cows bearing a single embryo were randomly assigned to a PRID (n=40; cows fitted with a progesterone releasing intra-vaginal device for 28 days), GnRH (n=40; cows receiving GnRH) or Control (n=26; untreated cows) group. PRID treatment led to a rise in plasma progesterone concentrations in the 7 days following the onset of treatment compared to the other two groups. In Experiment 2, in which we also examined twin pregnancies, animals were randomly assigned to PRID (n=312) or GnRH (n=294) treatment groups. Treatments were the same as described for Experiment 1. Logistic regression procedures revealed that in cows with a single corpus luteum, the probability of pregnancy loss between the first (Days 28-34) and second (Days 65-62) pregnancy diagnosis decreased by a factor of 0.51 in the PRID group compared to the GnRH group. However, in cows with two or more corpora lutea, PRID treatment increased the likelihood of pregnancy loss by a factor of three, compared to GnRH treatment. In cows carrying twins, the conceptus reduction rate was higher (P=0.02) for the GnRH (36%) than for the PRID (16.4%) group. Formation of a new corpus luteum was recorded in 17.7% of cows in the GnRH group. Our results indicate that compared to GnRH treatment, progesterone treatment given at pregnancy diagnosis in high producing dairy cows, reduced by a factor of 0.51 and increased by a factor of 3 the probability of pregnancy loss in cows with a single or with two or more corpora lutea, respectively, and reduced the conceptus reduction rate in cows carrying twins. The practical implications of our findings are that in herds with a high incidence of early fetal loss of a non-infectious nature, treatment at the time of pregnancy diagnosis with PRID in cows with one corpus luteum and with GnRH in cows with two or more corpora lutea should offer considerable benefits.
Disciplines :
Médecine vétérinaire & santé animale
Auteur, co-auteur :
Bech-Sabat, G.
Lopez-Gatius, F.
Garcia-Ispierto, I.
Santolaria, J. P.
Serrano, B.
Nogareda, C.
Melo de Sousa, Noelita ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Beckers, Jean-François ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Yaniz, J.
Langue du document :
Anglais
Titre :
Pregnancy patterns during the early fetal period in high producing dairy cows treated with GnRH or progesterone.
Royal M.D., Darwash A.O., Flint A.P.F., Webb R., Woolliams J.A., and Lamming G.E. Declining fertility in dairy cattle: changes in traditional and endocrine parameters of fertility. Anim Sci 70 (2000) 487-501
Lucy M.C. Reproductive loss in high-producing dairy cattle: Where will it end?. J Dairy Sci 84 (2001) 1277-1293
López-Gatius F. Is fertility declining in dairy cattle? A retrospective study in northeastern Spain. Theriogenology 60 (2003) 89-99
Committee on Bovine Reproductive Nomenclature. Recommendations for standardizing bovine reproductive terms. Cornell Vet 1972;62:216-37.
Ball P.H.J. Late embryo and early fetal mortality in the cow. Anim Breed Abs 65 (1997) 167-175
Hanzen C.H., Drion P.V., Loutrie O., Depierreux C., and Christians E. Embryonic mortality. Part 1. Clinical aspects and etiological factors on the bovine species. Ann Med Vet 143 (1999) 91-118
Vanroose G., de Kruif A., and Van Soom A. Embryonic mortality and embryo-pathogen interactions. Anim Reprod Sci 60-61 (2000) 131-143
Forar A.L., Gay J.M., and Hancock D.D. The frequency of endemic fetal loss in dairy cattle: a review. Theriogenology 43 (1995) 989-1000
Day J.D., Weaver L.D., and Franti C.E. Twin pregnancy diagnosis in Holstein cows: discriminatory powers and accuracy of diagnosis by transrectal palpation and outcome of twin pregnancies. Can Vet J 36 (1995) 93-97
Markusfeld-Nir O. Epidemiology of bovine abortions in Israeli dairy herds. Prev Vet Med 32 (1997) 245-255
Santos J.E.P., Thatcher W.W., Chebel R.C., Cerri R.L.A., and Galvão K.N. The effect of embryonic death rates in cattle on the efficacy of estrus synchronization programs. Anim Reprod Sci 82-83 (2004) 513-535
López-Gatius F., Santolaria P., Yániz J.L., Garbayo J.M., and Hunter R.H.F. Timing of early foetal loss for single and twin pregnancies in dairy cattle. Reprod Domest Anim 39 (2004) 429-433
Curran S., Pierson R.A., and Ginther O.J. Ultrasonographic appearance of the bovine conceptus from days 20 through 60. JAVMA 189 (1986) 1295-1302
Riding G.A., Lehnert S.A., French A.J., and Hill J.R. Conceptus-related measurements during the first trimester of bovine pregnancy. Vet J 175 (2008) 266-272
Labèrnia J., López-Gatius F., Santolaria P., López-Béjar M., and Rutllant J. Influence of management factors on pregnancy attrition in dairy cattle. Theriogenology 45 (1996) 1247-1253
López-Gatius F., Santolaria P., Yaniz J., Rutllant J., and López-Béjar M. Factors affecting pregnancy loss from gestation day 38 to 90 in lactating dairy cows from a single herd. Theriogenology 57 (2002) 1251-1261
Silke V., Diskin M.G., Kenny D.A., Boland M.P., Dillon P., Mee J.F., et al. Extent, pattern and factors associated with late embryonic loss in dairy cows. Anim Reprod Sci 71 (2002) 1-12
Grimard B., Freret S., Chevallier A., Pinto A., Ponsart C., and Humblot P. Genetic and environmental factors influencing first service conception rate and late embryonic/foetal mortality in low fertility dairy herds. Anim Reprod Sci 91 (2006) 31-44
Gábor G., Tóth F., Ózsvári L., Abonyi-Tóth Zs, and Sasser R.G. Factors influencing pregnancy rate and late embryonic loss in dairy cattle. Reprod Domest Anim 43 (2008) 53-58
García-Ispierto I., López-Gatius F., Santolaria P., Yániz J.L., Nogareda C., López-Béjar M., et al. Relationship between heat stress during the peri-implantation period and early fetal loss in dairy cattle. Theriogenology 65 (2006) 799-807
Bech-Sàbat G., López-Gatius F., Yániz J.L., García-Ispierto I., Santolaria P., Serrano B., et al. Factors affecting plasma progesterone in the early fetal period in high producing dairy cows. Theriogenology 69 (2008) 426-432
Bartolome J.A., Kamimura S., Silvestre F., Arteche A.C.M., Trigg T., and Thatcher W.W. The use of a deslorelin implant (GnRH agonist) during the late embryonic period to reduce pregnancy loss. Theriogenology 65 (2006) 1443-1453
Sawyer H.R. Structural and functional properties of the corpus luteum of pregnancy. In: Scaramuzzi R.J., Nancarrow C.D., and Doberska C. (Eds). Reproduction in domestic ruminants III (1995), J Reprod Fertil Ltd., Cambridge 97-110
Niswender G.D., Juengel J.L., Silva P.J., Rollyso M.K., and McIntush E.W. Mechanisms controlling the function and life span of the corpus luteum. Physiol Rev 80 (2000) 1-29
Spencer T.E., Johnson G.A., Burghart R.C., and Bazer F.W. Progesterone and placental hormone actions on the uterus: insights from domestic animals. Biol Reprod 71 (2004) 2-10
Starbuck M.J., Dailey R.A., and Inskeep E.K. Factors affecting retention of early pregnancy in dairy cattle. Anim Reprod Sci 84 (2004) 27-39
Ayad A., Sousa N.M., Sulon J., Hornick J.L., Watts J., López-Gatius F., et al. Influence of progesterone concentrations on secretory functions of trophoblast and pituitary during the first trimester of pregnancy in dairy cattle. Theriogenology 67 (2007) 1503-1511
Sangsritavong S., Combs D.K., Sartori R., Armentano L.E., and Wiltbank M.C. High feed intake increases liver blood flow and metabolism of progesterone and estradiol-17β in dairy cattle. J Dairy Sci 85 (2002) 2831-2842
López-Gatius F., Santolaria P., Yániz J.L., and Hunter R.H.F. Progesterone supplementation during the early fetal period reduces pregnancy loss in high-yielding dairy cattle. Theriogenology 62 (2004) 1529-1535
López-Gatius F., Santolaria P., Martino A., Delètang F., and De Rensis F. The effects of GnRH treatment at the time of AI and 12 days later on reproductive performance of high producing diary cows during the warm season in north-eastern Spain. Theriogenology 65 (2006) 820-830
National Research Council. Nutrient requirements of dairy cattle. 7th rev. ed. (2001), National Academic Science, Washington, DC
López-Gatius F., Garbayo J.M., Santolaria P., Yániz J., Ayad A., de Sousa N.M., et al. Milk production correlates negatively with plasma levels of pregnancy-associated glycoprotein (PAG) during the early fetal period in high producing dairy cows with live fetuses. Domest Anim Endocrinol 32 (2007) 29-42
Labèrnia J., López-Gatius F., Santolaria P., López-Béjar M., and Rutllant J. Influence of calving season on the interactions among reproductive disorders of dairy cows. Anim Sci 67 (1998) 387-393
Hosmer D.W., and Lemeshow S. Applied logistic regression (1989), Wiley, New York
Van Cleeff J., Lucy M.C., Wilcox C.J., and Thatcher W.W. Plasma and milk progesterone and plasma LH in ovariectomized lactating cows treated with new or used controlled internal drug release devices. Anim Reprod Sci 27 (1992) 91-106
Nation D.P., Burke C.R., Parton G., Stevenson R., and Macmillan K.L. Hormonal and ovarian responses to a 5-day progesterone treatment in anoestrous dairy cows in the third week post-partum. Anim Reprod Sci 63 (2000) 13-25
McDougall S., Compton C.W.R., and Anniss F.M. Effect of exogenous progesterone and oestradiol on plasma progesterone concentrations and follicle wave dynamics in anovulatory anoestrous post-partum dairy cattle. Anim Reprod Sci 84 (2004) 303-314
Keefe G., Squires E.J., Walsh R., Wilson J.B., and Leslie K.E. Impact of a progesterone-releasing intravaginal device on plasma progesterone levels in lactating dairy cattle. Bov Pract 40 (2006) 108-112
Lynch P.R., Macmillan K.L., and Taufa V.K. Treating cattle with progesterone as well as a GnRH analogue affects oestrous cycle length and fertility. Anim Reprod Sci 56 (1999) 189-200
Mann G.E., Fray M.D., and Lamming G.E. Effects of time of progesterone supplementation on embryo development and interferon-τ production in the cow. Vet J 171 (2006) 500-503
Larson S.F., Butler W.R., and Currie W.B. Pregnancy rates in lactating dairy cattle following supplementation of progesterone after artificial insemination. Anim Reprod Sci 102 (2007) 172-179
Peters A.R. Veterinary clinical application of GnRH - questions of efficacy. Anim Reprod Sci 88 (2005) 155-167
Robinson N.A., Leslie K.E., and Walton J.S. Effect of treatment with progesterone on pregnancy rate and plasma concentrations of progesterone in Holstein cows. J Dairy Sci 72 (1989) 202-207
Szekeres-Bartho J., Barakonyi A., Par G., Polgar B., Palkovics T., and Szereday L. Progesterone as an immunomodulatory molecule. Int Immunopharmacol 1 (2001) 1037-1048
Druckmann R., and Druckmann M.A. Progesterone and the immunology of pregnancy. J Steroid Biochem Mol Biol 97 (2005) 389-396
Wolf E., Arnold G.J., Bauersachs S., Beier H.M., Blum H., Einspanier R., et al. Embryo-maternal communication in bovine - strategies for deciphering a complex cross-talk. Reprod Domest Anim 38 (2003) 276-289
Spencer T.E., and Bazer F.W. Conceptus signals for establishment and maintenance of pregnancy. Reprod Biol Endocrinol 2 (2004) 49-63
López-Gatius F., and Hunter R.H.F. Spontaneous reduction of advanced twin embryos: its occurrence and clinical relevance in dairy cattle. Theriogenology 63 (2005) 118-125
Thatcher W.W., Macmillan K.L., Hansen P.J., and Drost M. Concepts for regulation of corpus luteum function by the conceptus and ovarian follicles to improve fertility. Theriogenology 31 (1989) 149-164
López-Gatius F., Pabon M., and Almería S. Neospora caninum infection does not affect early pregnancy in dairy cattle. Theriogenology 62 (2004) 606-613
