Influence of thermoelectric coupling on pacemaker activity generated by mechano-electric feedback in a one-dimensional ring-shaped model of cardiac fiber
[en] The mechano-electric feedback (MEF) in the heart consists in the influence of the tissue deformations on the cardiac electrical activity. Under certain conditions, tissue deformations can generate electrical perturbations via stretch-activated channels, such that the membrane potential can exceed the threshold value needed in order to trigger cardiac action potentials (APs). In the present study, we have developed a one-dimensional ring-shaped model of cardiac fiber taking into account three different couplings: the excitation-contraction coupling (ECC), the MEF and the thermoelectric coupling (TEC). The main goal of this work is to examine the effects of the TEC on the different properties of the pacemaker activity generated by the MEF.
Research Center/Unit :
Thermodynamique des Phénomènes Irréversibles (TPI) Laboratoire de mécanique numérique non linéaire (MN²L)
Disciplines :
Mechanical engineering
Author, co-author :
Collet, Arnaud ; Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Desaive, Thomas ; Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Pierard, Luc ; Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Boman, Romain ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > LTAS-Mécanique numérique non linéaire
Dauby, Pierre ; Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Language :
English
Title :
Influence of thermoelectric coupling on pacemaker activity generated by mechano-electric feedback in a one-dimensional ring-shaped model of cardiac fiber
Publication date :
01 June 2011
Event name :
2011 NHLBI /VCU - World Congress on Mathematical Modeling and Computational Simulation of Cardio vascular and Cardiopulmonary Dynamics
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