Article (Scientific journals)
Descriptive study of 32 cases of doxycycline-overdosed calves.
Brihoum, Mounir; Amory, Hélène; Desmecht, Daniel et al.
2010In Journal of Veterinary Internal Medicine, 24 (5), p. 1203-10
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Keywords :
Animals; Anti-Bacterial Agents/administration & dosage/adverse effects; Cardiology; Cattle; Cattle Diseases/chemically induced/mortality; Doxycycline/administration & dosage/adverse effects; Kidneys; Liver; Muscle, Skeletal/pathology; Myocardium/pathology; Overdose; Retrospective Studies; Tongue/pathology; Toxicity
Abstract :
[en] BACKGROUND: Reports of doxycycline-induced toxicity are limited despite common use of this antibiotic to treat infectious respiratory disorders in calves. OBJECTIVE: To describe previously unreported kidney lesions and diagnostic test results in doxycycline-overdosed calves and to compare these results with other findings reported previously. ANIMALS: Thirty-two calves that presented with adverse effects after receiving high doses of doxycycline as a treatment for mild respiratory disorders. METHOD: Retrospective review of medical records. RESULTS: Clinical examination identified mainly lethargy, dyspnea, cough, tongue paresia or paralysis associated with dysphagia and sialorrhea, tachycardia, tachypnea, and signs of myopathy. Blood analysis indicated increases in creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and sorbitol dehydrogenase activities and increased serum creatinine and urea concentrations. ECG recordings and Doppler echocardiography examination identified ventricular premature beats and a decrease in left ventricular global and systolic function, respectively. Necropsy and histopathology disclosed necrosis of the myocardium, tongue, and some striated muscles, acute renal tubular necrosis, and fatty degeneration or congestion of the liver. CONCLUSIONS: Most of these findings corroborate previous observations made in doxycycline-overdosed calves, and further suggest myocardial and striated muscular toxicity as well as renal toxicity in doxycycline-overdosed calves.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Brihoum, Mounir ;  Université de Liège - ULiège > Doct. sc. vété. (Bologne)
Amory, Hélène ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés
Desmecht, Daniel ;  Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies
Cassart, Dominique ;  Université de Liège - ULiège > Département de morphologie et pathologie > Département de morphologie et pathologie
Deleuze, Stefan  ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Obstét. et path. de la reprod. des anim. de comp. et équidés
Rollin, Frédéric ;  Université de Liège - ULiège > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs
Language :
English
Title :
Descriptive study of 32 cases of doxycycline-overdosed calves.
Alternative titles :
[en] Etude descriptive de 32 cas de surdosage à la doxycycline chez des veaux.
Publication date :
2010
Journal title :
Journal of Veterinary Internal Medicine
ISSN :
0891-6640
eISSN :
1939-1676
Publisher :
Allen Press, Lawrence, United States - Kansas
Volume :
24
Issue :
5
Pages :
1203-10
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 June 2011

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