Reference : Antioxydant activity of β-carboline derivatives in the LDL oxidation model
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/92667
Antioxydant activity of β-carboline derivatives in the LDL oxidation model
English
Hadjaz, Fariza [Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique > >]
Besret, Soizic [Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique > >]
Martin-Nizard, Françoise [Université Lille Nord de France > Institut Pasteur de Lille, Faculté de Pharmacie > > >]
Yous, Said [Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique > >]
Dilly, Sébastien mailto [Université de Liège - ULiège > Giga Neurosciences - CIRM > Laboratoire de pharmacologie - Laboratoire de Chimie Pharmaceutique > >]
Lebegue, Nicolas [Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique > >]
Chavatte, Philippe [Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique > >]
Duriez, Patrick [Université Lille Nord de France > Faculté de Pharmacie > Département de Pharmacologie Médicale > >]
Berthelot, Pascal [Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique > >]
Carato, Pascal mailto [Université Lille Nord de France > Faculté de Pharmacie > Laboratoire de Chimie Thérapeutique > >]
Jun-2001
European Journal of Medicinal Chemistry
Elsevier
46
2575-2585
Yes (verified by ORBi)
International
0223-5234
Paris
France
[en] beta-Carboline ; Antioxidant ; Inhibition LDL peroxidation ; Melatonin
[en] A series of b-carboline compounds were synthesized, starting from compound GWC22, their antioxidant activity was determined by inhibition of lipid peroxidation. The oxidation of LDL was induced in the presence of CuSO4 or 2,20-azobis(2-amidinopropane) dihydrochloride (AAPH). The protective actions of these compounds against the cytotoxicity were evaluated with lactate dehydrogenase (LDH) activity in bovine aortic endothelial cells (BAECs) and cellular vitality by measuring mitochondrial activity in the presence of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). Most of compounds showed an higher antioxidant activity than GWC22 derivative (R = 1.6 for 5 mM CuSO4). The best antioxidant activities are phenolic and benzyloxy derivatives with ratio R = 1.9 to 2.8 for 1 mM CuSO4. These substances have protective actions and increase significantly the cell viability.
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Université Lille Nord de France ; Département de Pharmacologie Médicale, Faculté de Pharmacie, Université Lille Nord de France ; Institut Pasteur de Lille, Faculté de Pharmacie, Université Lille Nord de France
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/92667

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