Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass (R) for tissue engineering applications
Roether, J. A.; Boccaccini, Aldo R.; Hench, L. L.et al.
[en] Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and homogeneous Bioglasss coatings on the surface of PDLLA foams as well as infiltration of Bioglass® particles throughout the porous network were achieved using a slurry-dipping technique in conjunction with pre-treatment of the foams in ethanol. The quality of the bioactive glass coatings was reproducible in terms of thickness and microstructure. Additionally, electrophoretic deposition was investigated as an alternative method for the fabrication of PDLLA foam/Bioglass® composite materials. In vitro studies in simulated body fluid (SBF) were performed to study the formation of hydroxyapatite (HA) on the surface of PDLLA/Bioglass® composites. SEM analysis showed that the HA layer thickness rapidly increased with increasing time in SBF. The high bioactivity of the PDLLA foam/Bioglasss composites indicates the potential of the materials for use as bioactive, resorbable scaffolds in bone tissue engineering.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Roether, J. A.; Imperial College, London, UK > Centre for Composite Materials
Boccaccini, Aldo R.; Imperial College, London, UK > Department of Materials and Centre for Tissue Engineering
Hench, L. L.; Imperial College, London, UK > Department of Materials and Centre for Tissue Engineering
Maquet, Véronique; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Gautier, Sandrine; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass (R) for tissue engineering applications
Nuffield Foundation EPSRC - Engineering and Physical Sciences Research Council MRC - Medical Research Council BELSPO - Politique scientifique fédérale F.R.S.-FNRS - Fonds de la Recherche Scientifique
Commentary :
The authors acknowledge Biomaterials (Elsevier) for allowing them to archive this paper.
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