[en] BACKGROUND: Some antibiotics represent a mainstay in acne treatment. However, studies comparing their efficacies are rare. AIM: To evaluate the clinical and in vivo antibacterial effect of lymecycline and minocycline at different dosages. METHOD: Eighty-six patients with moderate to severe acne were enrolled in a randomized, double-blind, intent-to-treat study comparing in three parallel groups the effect of (1) lymecycline 300 mg daily for 12 weeks, (2) minocycline 50 mg daily for 12 weeks and (3) minocycline 100 mg daily for 4 weeks followed by 50 mg daily for 8 weeks. Evaluations were made at the screening visit and at five on-treatment visits. They consisted of clinical counts of acne lesions and evaluations of bacterial viability using dual flow cytometry performed on microorganisms collected from sebaceous infundibula by cyanoacrylate strippings. RESULTS: Patients receiving minocycline 100/50 mg had the best clinical outcome, particularly in the reduction of the number of papules. By the end of the trial, the microbial response to minocycline 100/ 50 mg was also superior to either of the other two treatments. There were less live and more dead bacteria. CONCLUSION: In this trial, minocycline 100/50 mg was superior for the treatment of inflammatory acne when compared to lymecycline 300 mg and minocycline 50 mg.
Disciplines :
Dermatology
Author, co-author :
Pierard, Claudine ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Goffin, Véronique ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Arrese Estrada, Jorge ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Martalo, Oriane; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Braham, Catherine; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Slachmuylders, Patricia
Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Lymecycline and minocycline in inflammatory acne: a randomized, double-blind intent-to-treat study on clinical and in vivo antibacterial efficacy.
Harrison P.V. (1988) A comparison of doxycycline and minocycline in the treatment of acne vulgaris. Clin Exp Dermatol 13:242-244.
Eady E.A., Cove J.H., Holland K.T., Cunliffe W.J. (1990) Superior antibacterial action and reduced incidence of bacterial resistance in minocycline-compared to tetracycline-treated acne patients. Br J Dermatol 122:233-244.
Leyden J.J., Kaidbey K., Gans E.H. (1996) The antimicrobial effects in vivo of minocycline, doxycycline and tetracycline in humans. J Dermatol Treat 7:223-225.
Gardner K.J., Eady E.A., Cove J.H. (1997) Comparison of serum antibiotic levels in acne patients receiving the standard or a modified release formulation of minocycline hydrochloride. Clin Exp Dermatol 22:72-76.
Piérard G.E., Arrese J.E., Claessens N., Greimers R., Piérard-Franchimont C., Naeyaert J.M. (1999) Résistances bactériennes au cours de l'antibiothérapie anti-acnéique. Comment en limiter le risque. Rev Med Liege 54:100-104.
Cunliffe W.J., Grosshans E., Belaïch S. (1998) A comparison of the efficacy and safety of lymecycline and minocycline in patients with moderately severe acne vulgaris. Eur J Dermatol 8:161-166.
Arrese J.E., Goffin V., Avila-Camacho M., Greimers R., Piérard G.E. (1998) A pilot study on bacterial viability in acne. Assessment using dual flow cytometry on microbials present in follicular casts and comedones. Int J Dermatol 37:461-464.
Gant V.A., Warnes G., Phillips I., Savidge G.F. (1993) The application of flow cytometry to the study of bacterial responses to antibiotics. J Med Microbiol 39:147-154.
Durodie J., Coleman K., Simpson C.N. (1995) Rapid detection of antimicrobial activity using flow cytometry. Cytometry 21:374-377.
Eady E.A., Jones C.E., Tipper J.L. (1993) Antibiotic resistant Propionibacteria in acne: Need for policies to modify antibiotic usage. Br Med J 306:555-556.
Eady E.A. (1998) Bacterial resistance in acne. Dermatology 196:59-66.
Espersen F. (1998) Resistance to antibiotics used in dermatological practice. Br J Dermatol 139(SUPPL. 53):4-8.
Mills O.H., Kligman A.M. (1983) The follicular biopsy. Dermatologica 167:57-63.
Piérard G.E., Piérard-Franchimont C., Goffin V. (1995) Digital image analysis of microcomedones. Dermatology 190:99-103.
Leyden J.J., McGinley K.J., Kligman A.M. (1982) Tetracycline and minocycline treatments, effects on skin surface lipid levels and Propionibacterium acnes. Arch Dermatol 118:19-22.
Kurokawa I., Nishijima S., Asada Y. (1988) The antibiotic susceptibility of Propionibacterium acnes: A 15-year bacteriological study and retrospective evaluation. J Dermatol 15:149-154.
Kurokawa I., Nishijima S., Kawabata S. (1999) Antimicrobial susceptibility of Propionibacterium acnes isolated from acne vulgaris. Eur J Dermatol 9:25-28.