Article (Scientific journals)
Phosphoinositide phosphatases in a network of signaling reactions
Blero, D.; Payrastre, B.; Schurmans, Stéphane et al.
2007In Pflügers Archiv: European Journal of Physiology, 455, p. 31-44
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Keywords :
Poly-phosphoinositides; Inositol; 1,4,5-trisphosphate; PTEN; Inositol polyphosphate; 5-phosphatases; myotubularin; SHIP phosphatases
Abstract :
[en] Phosphoinositide phosphatases dephosphorylate the three positions (D-3, 4 and 5) of the inositol ring of the poly-phosphoinositides. They belong to different families of enzymes. The PtdIns(3,4)P(2) 4-phosphatase family, the tumour suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN), SAC1 domain phosphatases and myotubularins belong to the tyrosine protein phosphatases superfamily. They share the presence of a conserved cysteine residue in the consensus CX(5)RT/S. Another family consists of the inositol polyphosphate 5-phosphatase isoenzymes. The importance of these phosphoinositide phosphatases in cell regulation is illustrated by multiple examples of their implications in human diseases such as Lowe syndrome, X-linked myotubular myopathy, cancer, diabetes or bacterial infection
Disciplines :
Biochemistry, biophysics & molecular biology
Genetics & genetic processes
Author, co-author :
Blero, D.;  Université Libre de Bruxelles - ULB > Interdisciplinary Research Institute (IRIBHM)
Payrastre, B.;  Hôpital Purpan, 31059 Toulouse Cedex, France > Inserm U563, Département d’Oncogenèse et Signalisation dans les Cellules Hématopoïétiques, CPTP, IFR 30
Schurmans, Stéphane  ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie métabolique vétérinaire
Erneux, C.;  Université Libre de Bruxelles - ULB > Interdisciplinary Research Institute (IRIBHM)
Language :
English
Title :
Phosphoinositide phosphatases in a network of signaling reactions
Publication date :
2007
Journal title :
Pflügers Archiv: European Journal of Physiology
ISSN :
0031-6768
eISSN :
1432-2013
Publisher :
Springer Science & Business Media B.V.
Volume :
455
Pages :
31-44
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 January 2010

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