[fr] Le syndrome douloureux régional complexe (SDRC) reste mal compris et difficile à traiter. Les critères de définition du IASP (International Association for the Study of Pain) de 1994 ont conduit à une surestimation de diagnostic. Une révision de ces critères a eu lieu en 2003 à Budapest permettant d’améliorer la spécificité de ces critères.
Par ailleurs, la pathophysiologie est mal connue, un seul mécanisme ne peut expliquer toutes les altérations rencontrées dans le SDRC : l’inflammation neurogénique excessive, les altérations nerveuses périphériques et centrales …
Enfin, les différentes explorations paracliniques sont passées en revue. Malheureusement, il n’existe pas encore de test de laboratoire permettant le diagnostic de SDRC. Celui-ci repose sur l’anamnèse et un examen clinique soigneux. Les examens d’imagerie et neurophysiologiques et l’évaluation des paramètres inflammatoires aident au diagnostic différentiel. [en] Complex regional pain syndrome (CRPS) remains difficult to understand and to treat.
The definition criteria of the IASP (International Association for the Study of Pain) in 1994 showed an overestimation of diagnosis. A revision of these criteria conducted in Budapest in 2003 permits to ameliorate the specificity of these criteria in clinical and research settings.
Pathophysiology is poorly understood, only one mechanism can’t explain the observed manifestations in the CRPS: facilitated neurogenic inflammation, peripheral and central abnormalities of the central nervous system …
Finally, the different laboratory tests are reviewed. Unfortunately, no laboratory test is the signature of CRPS. The diagnosis relies on history and rigorous clinical examination. Imagery method, neurophysiologic test and evaluation of inflammatory parameters help to the differential diagnosis.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Fontaine, Robert ; Université de Liège - ULiège > Anesthésie et réanimation > Centre de la Douleur
Teuwis, Sandrine ; Université de Liège - ULiège > Anesthésie et réanimation > Centre de la Douleur
Faymonville, Marie ; Université de Liège - ULiège > Anesthésie et réanimation > Centre de la Douleur
Language :
French
Title :
Quoi de neuf dans le Syndrome Douleur Régional Complexe (SDRC) encore appelé algoneurodystrophie
Alternative titles :
[en] What's new in complex regional pain syndrome (CRPS) or reflex sympathetic dystrophy ?
P.J. Albrecht S. Hines E. Eisenberg, et al. 2006 Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome Pain 120 244 266 10.1016/j.pain.2005.10.035 16427199 (Pubitemid 43172860)
M. Bernateck R. Rolke F. Birklein, et al. 2007 Successful intravenous regional block with low-dose tumor necrosis factoralpha antibody infliximab for treatment of complex regional pain syndrome 1 Anesth Analg 105 1148 1151 10.1213/01.ane.0000278867.24601.a0 1:CAS:528:DC%2BD2sXhtVKmt7%2FF 17898403 (Pubitemid 47479337)
F. Birklein B. Riedl D. Claus, et al. 1998 Pattern of autonomic dysfunction in time course of complex regional pain syndrome Clin Auton Res 8 79 85 10.1007/BF02267817 1:STN:280:DyaK1c3ntlykug%3D%3D 9613797 (Pubitemid 28200717)
F. Birklein B. Riedl N. Sieweke, et al. 2000 Neurological findings in complex regional pain syndromes - analysis of 145 cases Acta Neurol Scand 101 262 269 10.1034/j.1600-0404.2000.101004262x./ 1:STN:280:DC%2BD3c3jtFaqsQ%3D%3D 10770524 (Pubitemid 30155155)
F. Birklein M. Schmelz S. Schifter M. Weber 2001 The important role of neuropeptides in complex regional pain syndrome Neurology 57 2179 2184 1:CAS:528:DC%2BD38XkvFyrsw%3D%3D 11756594 (Pubitemid 34016448)
F. Blaes K. Schmitz Tschernatsch, et al. 2004 Autoimmune etiology of complex regional pain syndrome (M. Sudeck) Neurology 63 1734 1736 1:STN:280:DC%2BD2crmt1emsA%3D%3D 15534271 (Pubitemid 39507605)
D. Bouhassira N. Attal J. Fermanian, et al. 2004 Development and validation of the Neuropathic Pain Symptom Inventory Pain 108 248 257 10.1016/j.pain.2003.12.024 15030944 (Pubitemid 38353047)
K. Christensen E.M. Jensen I. Noer 1982 The reflex sympathetic dystrophy syndrome response to treatment with systemic corticosteroids Acta Chir Scand 148 653 655 1:STN:280:DyaL3s3gtVSjsA%3D%3D 6763435 (Pubitemid 13221465)
L. Claes W. Vandereycken 2007 Self-injurious behavior: differential diagnosis and functional differentiation Comp Psychiatry 48 137 144 10.1016/j.comppsych.2006.10.009 (Pubitemid 46204675)
T.J. Coderre D.N. Xanthos L. Francis G.J. Bennet 2004 Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type 1 (CRPS-1; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat Pain 112 94 105 10.1016/j.pain.2004. 08.001 15494189 (Pubitemid 39371024)
M. De Mos A.G.J. De Bruijn F.J.P.M. Huygen, et al. 2007 The incidence of complex regional pain syndrome: a population-based study Pain 129 12 20 10.1016/j.pain.2006.09.008 17084977 (Pubitemid 46551364)
M. De Mos F.J. Huygen J.P. Dieleman, et al. 2008 Medical history and the onset of complex regional pain syndrome (CRPS) Pain 139 458 466 10.1016/j.pain.2008.07.002 18760877
V.E. Drory A.D. Korczyn 1995 The sympathetic skin response in reflex sympathetic dystrophy J Neurol Sci 128 92 95 10.1016/0022-510X(94)00210-F 1:STN:280:DyaK2M3jvFahtA%3D%3D 7722539
P.D. Drummond S. Skipworth P.M. Finch 1996 Alpha-1-adrenoceptors in normal and hyperalgesic human skin Clin Sci (London) 91 73 77 1:STN:280:DyaK28zntVeltQ%3D%3D (Pubitemid 26238299)
E. Eisenberg S. Shtahl R. Geller, et al. 2008 Serum and salivary oxidative analysis in complex regional pain syndrome Pain 138 226 232 10.1016/j.pain.2008.04.019 1:CAS:528:DC%2BD1cXoslCms7Y%3D 18539395
A. Goebel M. Stock R. Deacon, et al. 2005 Intravenous immunoglobulin response and evidence for pathogenic autoantibodies in a case of complex regional pain syndrome 1 Ann Neurol 57 463 464 10.1002/ana.20400 15732112 (Pubitemid 40343974)
A. Goebel H. Vogel O. Caneris, et al. 2005 Immune response to campylobacter and serum antibodies in patients with complex regional pain syndrome J Neuroimmunol 162 184 189 10.1016/j.jneuroim.2005.01.018 1:CAS:528:DC%2BD2MXjtFyrtrY%3D 15833374 (Pubitemid 40503113)
J.G. Groeneweg F.J. Huygen C. Heijmans-Antonissen, et al. 2006 Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1 BMC Musculoskelet Disord 7 91 10.1186/1471-2474-7-91 17137491 (Pubitemid 44912703)
O. Gross M. Tschernatsch M.E. Braü, et al. 2007 Increased seroprevalence of parvovirus B19 IgG in complex regional pain syndrome is not associated with antiendothelial autoimmunity Eur J Pain 11 237 240 10.1016/j.ejpain.2006.01.006 16545972 (Pubitemid 44820895)
R.N. Harden S. Bruehl M. Stanton-Hicks P.R. Wilson 2007 Proposed new criteria for complex regional pain syndrome Pain Med 8 326 331 10.1111/j.1526-4637.2006.00169.x 17610454 (Pubitemid 47039415)
R.N. Harden T.A. Duc T.R. Williams, et al. 1994 Norepinephrine and epinephrine levels in affected versus unaffected limbs in sympathetically maintained pain Clin J Pain 10 324 330 1:STN:280:DyaK2M7mtFylug%3D%3D 7858364
L.E. Holder S.E. Mackinnon 1984 Reflex sympathetic dystrophy in the hands: clinical and scintigraphic criteria Radiology 152 517 522 1:STN:280:DyaL2c3kvVynug%3D%3D 6739825
F.J. Huygen A.G. De Bruijn M.T. De Bruin, et al. 2002 Evidence for local inflammation in complex regional pain syndrome type 1 Mediators Inflamm 11 47 51 10.1080/09629350210307 1:CAS:528:DC%2BD38XjtVGgsr0%3D 11930962 (Pubitemid 34252547)
F.J. Huygen S. Niehof F.J. Zijlstra 2004 Successful treatment of CRPS 1 with anti-TNF J Pain Symptom Manag 27 101 103 10.1016/j.jpainsymman.2003.12.006 (Pubitemid 38221067)
W. Janig R. Baron 2003 Complex regional pain syndrome: mystery explained? Lancet Neurol 2 687 697 10.1016/S1474-4422(03)00557-X 14572737 (Pubitemid 37311322)
H.A. Kürvers M.J. Jacobs R.J. Beuk, et al. 1996 The spinal component to skin flow abnormalities in reflex sympathetic dystrophy Arch Neurol 53 58 65 8599560 (Pubitemid 26023285)
A. Mailis-Gagnon K. Nicholson Blumberger M. Zurowski 2008 Characteristics and period prevalence of self-induced disorder in patient referred to a pain clinic with the diagnosis of complex regional pain syndrome Clin J Pain 24 176 185 10.1097/AJP.0b013e31815ca278 18209524 (Pubitemid 351156519)
J. Marinus J.J. Van Hilten 2006 Clinical expression profiles of complex regional pain syndrome, fibromyalgia and a-specific repetitive strain injury: more common denominator than pain? Disabil Rehabil 28 351 362 10.1080/09638280500287320 16492631 (Pubitemid 43307458)
C.S. McCabe R.C. Haigh E.F.J. Ring, et al. 2003 A controlled pilot study of the utility of mirror visual feedback in the treatment of complex regional pain syndrome (type 1) Rheumatology 42 97 101 10.1093/rheumatology/keg041 1:STN:280:DC%2BD3s%2FktlCjsQ%3D%3D 12509620 (Pubitemid 36131574)
R.S. Perez W.W. Zuurmond P.D. Bezemer, et al. 2003 The treatment of complex regional pain syndrome type 1 with free radical scavengers: a randomised controlled study Pain 102 297 307 10.1016/S0304-3959(02)00414-1 1:CAS:528:DC%2BD3sXisV2ltLs%3D 12670672 (Pubitemid 36369309)
P. Puchalski A. Zyluk 2005 Complex regional pain syndrome type 1 after fractures of the distal radius: a prospective study of the role of psychological factors J Hand Surg 30 574 580 1:STN:280:DC%2BD2Mrns1Cgug%3D%3D (Pubitemid 41614187)
J. Rodriguez-Moreno J.M. Ruiz Martin L. Mateo-Soria, et al. 1990 Munchhausen's syndrome simulating reflex sympathetic dystrophy Ann Rheum Dis 49 1010 1012 10.1136/ard.49.12.1010 1:STN:280:DyaK3M7gtlKitw%3D%3D 2270960
Rommel O, Häbler HJ, Schürmann M (2005) Labory test for complex regional pain syndrome. In: Wilson P, Stanton-Hicks M, Norman Harden R (eds) CRPS: current diagnosis and therapy, progress in pain research and management, vol 32, IASP Press, Seattle
O. Rommel J.P. Malin M. Zenz, et al. 2001 Quantitative sensory testing, neurophysiological and psychological examination in patients with complex regional pain syndrome and hemisensory deficits Pain 93 279 293 10.1016/S0304-3959(01)00332-3 1:STN:280:DC%2BD3MvmvFyjtg%3D%3D 11514087 (Pubitemid 32763185)
O. Rommel M. Tegenthoff U. Pern, et al. 1995 Sympathetic skin response in patients with reflex sympathetic dystrophy Clin Auton Res 5 205 210 10.1007/BF01824008 1:STN:280:DyaK28%2Fns1antw%3D%3D 8520215
Schattschneider J, Wenzelburger R, Deuschl G, et al (2001) Kinematic analysis of the upper extremity in CRPS. In: Harden RN, Baron R, Janig W (eds) Complex regional pain syndrome. IASP Press, Seattle, pp. 119-128
A.C. Schouten W.J. Van de Beek J.J. Van Hilten, et al. 2003 Proprioceptive reflexes in patient with reflex sympathetic dystrophy Exp Brain Res 151 1 8 10.1007/s00221-003-1420-x 1:STN:280:DC%2BD3szovVCnsg%3D%3D 12743675 (Pubitemid 36819149)
M. Schürmann G. Gradl H.J. Andress, et al. 1999 Assessment of peripheral sympathetic nervous function for diagnosing early post-traumatic complex regional pain syndrome type 1 Pain 80 149 159 10.1016/S0304-3959(98) 00198-5 10204727 (Pubitemid 29151699)
M. Schürmann G. Gradl I. Wizgal, et al. 2001 Clinical and physiologic evaluation of stellate ganglion blockade for complex regional pain syndrome type 1 Clin J Pain 17 94 100 10.1097/00002508-200103000-00012 11289093 (Pubitemid 32225170)
M. Schürmann G. Gradl J. Zaspel, et al. 2000 Peripheral sympathetic function as a predictor of complex regional pain syndrome type 1 (CRPS 1) in patient with radial fracture Auton Neurosci 86 127 134 10.1016/S1566-0702(00) 00250-2 11269918
M. Schurmann J. Zaspel P. Löhr, et al. 2007 Imaging in early posttraumatic complex regional pain syndrome: a comparison of diagnostic methods Clin J Pain 23 449 457 10.1097/AJP.0b013e31805c9e66 17515744 (Pubitemid 46791493)
R.J. Schwartzman E. Chevlen K. Bengtson 2003 Thalidomide has activity in treating complex regional pain syndrome Arch Intern Med 163 1487 1488 10.1001/archinte.163.12.1487 12824100 (Pubitemid 36758923)
R.J. Schwartzmann J. Kerrigan 1990 The mouvement disorder of reflex sympathetic dystrophy Neurology 40 57 61 (Pubitemid 20032893)
M.E. Schweitzer S. Mandel R.J. Schwartzmann, et al. 1995 Reflex sympathetic dystrophy revisited: MR imaging findings before and after infusion of contrast material Radiology 195 211 214 1:STN:280:DyaK2M7pvFGmtQ%3D%3D 7892471
A. Sharma S. Agarwal J. Broatch S.N. Raja 2009 A web-based cross-sectional epidemiological survey of complex regional pain syndrome Reg Anesth Pain Med 34 110 115 10.1097/AAP.0b013e3181958f90 19282709
L. Van der Laan K. Van Spaendonck M.W. Horstink R.J. Goris 1999 The Symptom Checklist-90 Revised questionnaire: no psychological profiles in complex regional pain syndromedystonia J Pain Symptom Manage 17 357 362 10.1016/S0885-3924(99)00009-3 10355214 (Pubitemid 29239527)
P.H. Veldman H.M. Reynen I.E. Arntz, et al. 1993 Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients Lancet 342 1012 1016 10.1016/0140-6736(93)92877-V 1:STN:280:DyaK2c%2FhvVajtg%3D%3D 8105263 (Pubitemid 23314802)
G. Wasner J. Schattschneider R. Baron 2002 Skin temperature side differences: a diagnostic tool for CRPS? Pain 98 19 26 10.1016/S0304-3959(01) 00470-5 12098613 (Pubitemid 34722465)
G. Wasner J. Schattschneider C. Maier R. Baron 2001 Vascular abnormalities in reflex sympathetic dystrophy (CRPS 1): mechanism and diagnostic value Brain 124 587 599 10.1093/brain/124.3.587 1:STN:280: DC%2BD3M7ps1Chug%3D%3D 11222458 (Pubitemid 32221325)
L.R. Watkins S.F. Maier 2005 Immune regulation of central nervous functions: from sickness responses to pathological pain J Intern Med 257 139 155 10.1111/j.1365-2796.2004.01443.x 1:CAS:528:DC%2BD2MXit1ejurg%3D 15656873 (Pubitemid 40193964)
M. Weber F. Birklein B. Neundörfer M. Schmelz 2001 Facilitated neurogenic inflammation in complex regional pain syndrome Pain 91 251 257 10.1016/S0304-3959(00)00445-0 1:STN:280:DC%2BD3M7oslCrsw%3D%3D 11275381 (Pubitemid 32241145)