Article (Scientific journals)
Effect of catechins and citrus flavonoids on invasion in vitro.
Bracke, M.; Vyncke, B.; Opdenakker, G. et al.
1991In Clinical and Experimental Metastasis, 9 (1), p. 13-25
Peer Reviewed verified by ORBi
 

Files


Full Text
Bracke 1991.pdf
Publisher postprint (2.43 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Catechins, a group of flavonoid molecules, inhibit invasion of mouse MO4 cells into embryonic chick heart fragments in vitro. The anti-invasive effects can be ranked as follows: (+)-catechin greater than (-)-epicatechin greater than 3-O-methyl-(+)-catechin greater than 3-O-palmitoyl-(+)-catechin. Most of the catechins are unstable in cell culture media, and their spontaneous rearrangement products tend to bind to extracellular matrix (ECM). Due to these interactions proteases such as tissue-type plasminogen activator (t-PA) are linked to the ECM glycoprotein laminin. This leads to a partial inactivation of the enzyme. Within the group of catechins we found a positive correlation between anti-invasive activity and linking of t-PA to laminin. Citrus flavonoids are also anti-invasive in vitro (tangeretin greater than nobiletin greater than hesperidin = naringin). However, these stable molecules show poor affinity for ECM, and do not link enzymes to laminin. These data suggest that catechins and citrus flavonoids inhibit invasion in vitro by different mechanisms.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bracke, M.
Vyncke, B.
Opdenakker, G.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
De Pestel, G.
Mareel, M.
Language :
English
Title :
Effect of catechins and citrus flavonoids on invasion in vitro.
Publication date :
1991
Journal title :
Clinical and Experimental Metastasis
ISSN :
0262-0898
Publisher :
Kluwer Academic Publishers, Dordrecht, Netherlands
Volume :
9
Issue :
1
Pages :
13-25
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 April 2011

Statistics


Number of views
34 (3 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
64
Scopus citations®
without self-citations
61
OpenCitations
 
45

Bibliography


Similar publications



Contact ORBi