Brain energization in response to deep brain stimulation of subthalamic nuclei in Parkinson's disease.

[en] Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment in a subgroup of medically refractory patients with Parkinson's disease (PD). Here, we compared resting-state (18)F-fluorodeoxyglucose (FDG) positron emission tomography images in the stimulator off (DBS_OFF) and on (DBS_ON) conditions in eight PD patients in an unmedicated state, on average 2 years after bilateral electrode implantation. Global standardized uptake value (SUV) significantly increased by approximately 11% in response to STN-DBS. To avoid any bias in the voxel-based analysis comparing DBS_ON and DBS_OFF conditions, individual scan intensity was scaled to a region where FDG-SUV did not differ significantly between conditions. The resulting FDG-SUV ratio (FDG-SUVR) was found to increase in many regions in response to STN-DBS including the target area of surgery, caudate nuclei, primary sensorimotor, and associative cortices. Contrary to previous studies, we could not find any regional decrease in FDG-SUVR. These findings were indirectly supported by comparing the extent of areas with depressed FDG-SUVR in DBS_OFF and DBS_ON relatively to 10 normal controls. Altogether, these novel results support the prediction that the effect of STN-DBS on brain activity in PD is unidirectional and consists in an increase in many subcortical and cortical regions.Journal of Cerebral Blood Flow & Metabolism advance online publication, 6 April 2011; doi:10.1038/jcbfm.2011.41.

Research center :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Radiology, nuclear medicine & imaging
Neurology

Author, co-author :

Garraux, Gaëtan ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Bahri, Mohamed Ali ; Université de Liège - ULiège > Centre de recherches du cyclotron

Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron

Degueldre, Christian ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Salmon, Eric ; Centre Hospitalier Universitaire de Liège - CHU > Neurochirurgie

KASCHTEN, Bruno

Language :

English

Title :

Brain energization in response to deep brain stimulation of subthalamic nuclei in Parkinson's disease.

Publication date :

April 2011

Journal title :

Journal of Cerebral Blood Flow and Metabolism

ISSN :

0271-678X

eISSN :

1559-7016

Publisher :

Nature Publishing Group, New York, United States - New York

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.nature.com/jcbfm/journal/vaop/ncurrent/full/jcbfm201141a.html

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Fonds Rahier

Available on ORBi :

since 12 April 2011

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