Antidepressants; Dexamethasone suppression test; Nomifensine; Prediction of outome; Zimeldine
Abstract :
[en] The usefulness of the dexamethasone suppression test (DST) in the prediction of treatment response to selective antidepressants was tested in 56 major depressive inpatients. Following DST, patients were randomly assigned to treatment by either nomifensine, a catecholaminergic antidepressant, or zimeldine, a serotonergic antidepressant during a 3-week period and assessed by means of the second part of the Clinical Global Impressions (CGI-2). No significant difference was present between the 27 DST suppressor and the 29 DST non-suppressor patients in their overall clinical outcome. Moreover, no preferential response to nomifensine or zimeldine was noted in any of the two groups defined according to DST status. Therefore, these results do not support the usefulness of the DST in the prediction of the treatment response to antidepressants in general and to selective antidepressants in particular.
Disciplines :
Psychiatry
Author, co-author :
ANSSEAU, Marc ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
PAPART, Patrick ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
PITCHOT, William ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Timsit-Berthier, Martine ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Legros, Jean-Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
von Frenckell, Rémy ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Language :
English
Title :
Dexamethasone suppression test and prediction of treatment response to selective antidepressants