Article (Scientific journals)
Reticular fibroblasts in peripheral lymphoid organs identified by a monoclonal antibody.
Van Vliet, E.; Melis, M.; Foidart, Jean-Michel et al.
1986In Journal of Histochemistry and Cytochemistry, 34 (7), p. 883-90
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Keywords :
Monoclonal antibodies;; Reticular fibroblasts; Spleen; Lymph node; Immunohistology; Mouse
Abstract :
[en] We have produced a panel of monoclonal antibodies directed against nonlymphoid cells in central and peripheral lymphoid organs. In this paper we present the reactivity of one of these antibodies, ER-TR7. This antibody detects reticular fibroblasts, which constitute the cellular framework of lymphoid and nonlymphoid organs and their products. In frozen sections of the spleen incubated with this antibody, the red pulp and white pulp are clearly delineated. Furthermore, the major white pulp compartments--the follicles and periarteriolar lymphoid sheath as well as the marginal zone--are recognized by their characteristic labeling patterns. In lymph nodes, the capsule, sinuses, follicles, paracortex, and medullary cords are clearly delineated. In the thymus and bone marrow no such specialized compartments were demonstrated. ER-TR7 reacts with an intracellular component of fibroblasts. Since ER-TR7 does not react with purified laminin, collagen types I-V, fibronectin, heparan sulfate proteoglycan, entactin, or nidogen, it detects a hitherto uncharacterized antigen. The possible role of the ER-TR7 positive reticular fibroblasts in the cellular organization of peripheral lymphoid organs will be discussed.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Van Vliet, E.
Melis, M.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Van Ewijk, W.
Language :
English
Title :
Reticular fibroblasts in peripheral lymphoid organs identified by a monoclonal antibody.
Publication date :
1986
Journal title :
Journal of Histochemistry and Cytochemistry
ISSN :
0022-1554
eISSN :
1551-5044
Publisher :
Histochemical Society, New York, United States - New York
Volume :
34
Issue :
7
Pages :
883-90
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 March 2011

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