Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls

Vo, Thi Kim Duy; Godard, Patrice; de Saint-Hubert, Marie; Morrhaye, Gabriel; Debacq-Chainiaux, Florence; Swine, Christian; Geenen, Vincent; Martens, Henri; Toussaint, Olivier

doi:10.1016/j.exger.2010.10.012

Article (Scientific journals)

Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls

Vo, Thi Kim Duy; Godard, Patrice; de Saint-Hubert, Marie et al.

2011 • In Experimental Gerontology, 46, p. 257-264

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/87380

DOI
10.1016/j.exger.2010.10.012

PubMed
21074600

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Keywords :

Ageing; Hip fracture; PBMC; Gene expression; Inflammation; Immunosenescence; Oxidative stress

Abstract :

[en] The abundance of a selection of transcript species involved in in!ammation, immunosenescence and stress response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2–4 after hospitalization) or convalescence phase (days 7–10) and 28 healthy aged controls. Twenty-nine differentially abundant transcripts were identi"ed in acute phase versus healthy ageing. Twelve of these transcripts remained differentially abundant in convalescence phase, and 22 were similarly differentially abundant in acute phase of geriatric infectious diseases. Seven of these 22 transcripts were previously identi"ed as differentially abundant in PBMC of healthy aged versus healthy young controls, with further alteration for CD28, CD69, LCK, CTSD, HMOX1, and TNFRSF1A in acute phase after geriatric hip fracture and infectious diseases. The next question is whether these alterations are common to other geriatric diseases and/or preexist before the clinical onset of the diseases.

Disciplines :

Geriatrics
Immunology & infectious disease

Author, co-author :

Vo, Thi Kim Duy; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire

Godard, Patrice; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire

de Saint-Hubert, Marie; Université Catholique de Louvain - UCL > Gériatrie Mont-Godinne

Morrhaye, Gabriel; Université de Liège - ULiège > Centre d'Immunologie

Debacq-Chainiaux, Florence; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire

Swine, Christian; Université Catholique de Louvain - UCL > Gériatrie - Mont Godinne

Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie

Martens, Henri ; Université de Liège - ULiège > Centre d'immunologie

Toussaint, Olivier; Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire

Language :

English

Title :

Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls

Publication date :

2011

Journal title :

Experimental Gerontology

ISSN :

0531-5565

eISSN :

1873-6815

Publisher :

Elsevier Science, Tarrytown, United States - New York

Volume :

Pages :

257-264

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

SENEGENE

Funders :

DGTRE - Région wallonne. Direction générale des Technologies, de la Recherche et de l'Énergie
F.R.S.-FNRS - Fonds de la Recherche Scientifique

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