Article (Scientific journals)
Extensive Genome-Wide Linkage Disequilibrium in Cattle
Farnir, Frédéric; Coppieters, Wouter; Arranz, J. J. et al.
2000In Genome Research, 10 (2), p. 220-7
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Keywords :
linkage disequilibrium; dairy cattle; microsatellites
Abstract :
[en] A genome-wide linkage disequilibrium (LD) map was generated using microsatellite genotypes (284 autosomal microsatellite loci) of 581 gametes sampled from the dutch black-and-white dairy cattle population. LD was measured between all marker pairs, both syntenic and nonsyntenic. Analysis of syntenic pairs revealed surprisingly high levels of LD that, although more pronounced for closely linked marker pairs, extended over several tens of centimorgan. In addition, significant gametic associations were also shown to be very common between nonsyntenic loci. Simulations using the known genealogies of the studied sample indicate that random drift alone is likely to account for most of the observed disequilibrium. No clear evidence was obtained for a direct effect of selection ("Bulmer effect"). The observation of long range disequilibrium between syntenic loci using low-density marker maps indicates that LD mapping has the potential to be very effective in livestock populations. The frequent occurrence of gametic associations between nonsyntenic loci, however, encourages the combined use of linkage and linkage disequilibrium methods to avoid false positive results when mapping genes in livestock.
Disciplines :
Genetics & genetic processes
Animal production & animal husbandry
Author, co-author :
Farnir, Frédéric  ;  Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale
Coppieters, Wouter ;  Université de Liège - ULiège > Département de productions animales > Département de productions animales
Arranz, J. J.
Berzi, Paulette  ;  Université de Liège - ULiège > Services administratifs généraux > R&D : Gestion stratégique
Cambisano, Nadine ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Grisart, B.
Karim, Latifa ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Marcq, Fabienne ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés
Moreau, L.
Mni, Myriam ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Nezer, Carine ;  Université de Liège - ULiège > Département de sciences des denrées alimentaires > Microbiologie des denrées alimentaires
Simon, Patricia ;  Université de Liège - ULiège > Centre d'ingénierie des protéines
Vanmanshoven, P.
Wagenaar, D.
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
More authors (5 more) Less
Language :
English
Title :
Extensive Genome-Wide Linkage Disequilibrium in Cattle
Publication date :
February 2000
Journal title :
Genome Research
ISSN :
1088-9051
eISSN :
1549-5469
Publisher :
Cold Spring Harbor Laboratory Press, United States - New York
Volume :
10
Issue :
2
Pages :
220-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 March 2009

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