Liver lipid metabolism.

Animals; Fatty Acid Transport Proteins/metabolism; Fatty Acids/metabolism; Fatty Acids, Nonesterified/metabolism; Fatty Liver/metabolism/veterinary; Lipid Metabolism/physiology; Lipid Peroxidation; Liver/metabolism; Triglycerides/metabolism

Abstract :

[en] The liver plays a key role in lipid metabolism. Depending on species it is, more or less, the hub of fatty acid synthesis and lipid circulation through lipoprotein synthesis. Eventually the accumulation of lipid droplets into the hepatocytes results in hepatic steatosis, which may develop as a consequence of multiple dysfunctions such as alterations in beta-oxidation, very low density lipoprotein secretion, and pathways involved in the synthesis of fatty acids. In addition an increased circulating pool of non-esterified fatty acid may also to be a major determinant in the pathogenesis fatty liver disease. This review also focuses on transcription factors such as sterol-regulatory-element-binding protein-1c and peroxisome proliferator-activated receptor alpha, which promote either hepatic fatty acid synthesis or oxidation.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Nguyen, Patrick

Leray, Véronique

Diez, Marianne ; Université de Liège - ULiège > Département de productions animales > Nutrition des animaux domestiques

Serisier, Samuel

Le Bloc'h, J.

Siliart, Brigitte

Dumon, Henri

Language :

English

Title :

Liver lipid metabolism.

Publication date :

2008

Journal title :

Journal of Animal Physiology and Animal Nutrition

ISSN :

0931-2439

eISSN :

1439-0396

Publisher :

Blackwell Publishing, Oxford, United Kingdom

Volume :

Issue :

Pages :

272-83

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 March 2009

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163 (7 by ULiège)

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2 (1 by ULiège)

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Scopus citations^®

615

Scopus citations^®
without self-citations

615

OpenCitations

521

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