Reference : Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory...
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
http://hdl.handle.net/2268/85376
Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects.
English
Allez, Matthieu [> > > >]
Karmiris, Konstantinos [> > > >]
Louis, Edouard mailto [Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie >]
Van Assche, Gert [> > > >]
Ben-Horin, Shomron [> > > >]
Klein, Amir [> > > >]
Van der Woude, Janneke [> > > >]
Baert, Filip [> > > >]
Eliakim, Rami [> > > >]
Katsanos, Konstantinos [> > > >]
Brynskov, Jorn [> > > >]
Steinwurz, Flavio [> > > >]
Danese, Silvio [> > > >]
Vermeire, Severine [> > > >]
Teillaud, Jean*-Luc [> > > >]
Lemann, Marc [> > > >]
Chowers, Yehuda [> > > >]
2010
Journal of Crohn's and Colitis
Elsevier
4
4
355-66
Yes (verified by ORBi)
International
1873-9946
Amsterdam
Netherlands
[en] The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways.
http://hdl.handle.net/2268/85376
10.1016/j.crohns.2010.04.004
Copyright (c) 2010 European Crohn's and Colitis Organisation. All rights reserved.

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