[en] A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept
Research center :
Giga-Systems Biology and Chemical Biology - ULiège
Disciplines :
Chemistry
Author, co-author :
Lombardo, Caterina M.; CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK.
Martínez, Iria S.; CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK.
Haider, Shozeb; CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK.
Gabelica, Valérie ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)
De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)
Moses, John E.; The School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
Neidle, Stephen; CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK.
Language :
English
Title :
Structure-based design of selective high-affinity telomeric quadruplex-binding ligands
Publication date :
2010
Journal title :
Chemical Communications
ISSN :
1359-7345
eISSN :
1364-548X
Publisher :
Royal Society of Chemistry, Cambridge, United Kingdom
Volume :
46
Pages :
9116-9118
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
D. J. Patel A. T. Phan V. Kuryavyi Nucleic Acids Res. 2007 35 7429
S. Burge G. N. Parkinson P. Hazel A. K. Todd S. Neidle Nucleic Acids Res. 2006 34 5402
S. Neidle Curr. Opin. Struct. Biol. 2009 19 239
J. Huppert S. Balasubramanian Nucleic Acids Res. 2005 33 2908
A. Todd M. Johnston S. Neidle Nucleic Acids Res. 2005 33 2901
M. J. McEachern A. Krauskopf E. H. Blackburn Annu. Rev. Genet. 2000 34 331
J. L. Huppert S. Balasubramanian Nucleic Acids Res. 2006 35 406
See for example: A. Siddiqui-Jain C. L. Grand D. J. Bearss L. H. Hurley Proc. Natl. Acad. Sci. U. S. A. 2002 99 11593
Y. Qin J. S. Fortin D. Tye M. Gleason-Guzman T. A. Brooks L. H. Hurley Biochemistry 2010 49 4208
S. T. Hsu P. Varnai A. Bugaut A. P. Reszka S. Neidle S. Balasubramanian J. Am. Chem. Soc. 2009 131 13399
M. Gunaratnam S. Swank S. M. Haider K. Galesa A. P. Reszka M. Beltran F. Cuenca J. A. Fletcher S. Neidle J. Med. Chem. 2009 52 3774
For example: S. Kumari A. Bugaut J. L. Huppert S. Balasubramanian Nat. Chem. Biol. 2007 3 218
M. Wieland J. S. Hartig Chem. Biol. 2007 14 757
A. Bugaut R. Rodriguez S. Kumari S. T. Hsu S. Balasubramanian Org. Biomol. Chem. 2010 8 2771
J. Eddy N. Maizels Nucleic Acids Res. 2007 36 1321
D. Sun B. Thompson B. E. Cathers M. Salazar S. M. Kerwin J. O. Trent T. C. Jenkins S. Neidle L. H. Hurley J. Med. Chem. 1997 40 2113
P. Phatak J. C. Cookson F. Dai V. Smith R. B. Gartenhaus M. F. Stevens A. M. Burger Br. J. Cancer 2007 96 1223
J. W. Shay W. E. Wright Nat. Rev. Drug Discovery 2006 5 577
A. De Cian L. Lacroix C. Douarre N. Temime-Smaali C. Trentesaux J. F. Riou J. L. Mergny Biochimie 2008 90 131
D. Monchaud M.-P. Teulade-Fichou Org. Biomol. Chem. 2008 6 627
See for example: R. J. Harrison S. M. Gowan L. R. Kelland S. Neidle Bioorg. Med. Chem. Lett. 1999 9 2463
M.-K. Cheng C. Modi J. C. Cookson I. Hutchinson R. A. Heald A. J. McCarroll S. Missailidis F. Tanious W. D. Wilson J.-L. Mergny C. A. Laughton M. F. G. Stevens J. Med. Chem. 2008 51 963
M. Read R. J. Harrison B. Romagnoli F. A. Tanious S. H. Gowan A. P. Reszka W. D. Wilson L. R. Kelland S. Neidle Proc. Natl. Acad. Sci. U. S. A. 2001 98 4844
A. M. Burger F. Dai C. M. Schultes A. P. Reszka M. J. Moore J. A. Double S. Neidle Cancer Res. 2005 65 1489
N. H. Campbell G. N. Parkinson A. P. Reszka S. Neidle J. Am. Chem. Soc. 2008 130 6722
F. Rosu E. De Pauw V. Gabelica Biochimie 2008 90 1074
V. Gabelica Methods Mol. Biol. 2010 613 89
S. M. Haider S. Neidle Biochem. Soc. Trans. 2009 37 583
S. M. Haider S. Neidle Methods Mol. Biol. 2010 608 17 See also the ESI
A. D. Moorhouse A. M. Santos M. Gunaratnam M. Moore S. Neidle J. E. Moses J. Am. Chem. Soc. 2006 128 15972
H. C. Kolb M. G. Finn K. B. Sharpless Angew. Chem., Int. Ed. 2001 40 2004
A. T. Phan V. Kuryavyi K. N. Luu D. J. Patel Nucleic Acids Res. 2007 35 6517
A. Ambrus D. Chen J. Dai T. Bialis R. A. Jones D. Yang Nucleic Acids Res. 2006 34 2723
J. Das S. N. Patil R. Awasthi C. P. Narasimhulu S. Trehan Synthesis 2005 1801
G. Collie A. P. Reszka S. M. Haider V. Gabelica G. N. Parkinson S. Neidle Chem. Commun. 2009 7482
A. Casagrande A. Alvino G. Bianco G. Ortaggi M. Franceschin J. Mass Spectrom. 2009 44 530
T. P. Garner H. E. L. Williams K. I. Gluszyk S. Roe N. J. Oldham M. F. G. Stevens J. E. Moses M. S. Searle Org. Biomol. Chem. 2009 7 4194
