[en] A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept
Research Center/Unit :
Giga-Systems Biology and Chemical Biology - ULiège
Disciplines :
Chemistry
Author, co-author :
Lombardo, Caterina M.; CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK.
Martínez, Iria S.; CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK.
Haider, Shozeb; CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK.
Gabelica, Valérie ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)
De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)
Moses, John E.; The School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
Neidle, Stephen; CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK.
Language :
English
Title :
Structure-based design of selective high-affinity telomeric quadruplex-binding ligands
Publication date :
2010
Journal title :
Chemical Communications
ISSN :
1359-7345
eISSN :
1364-548X
Publisher :
Royal Society of Chemistry, Cambridge, United Kingdom
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