AVP- and OT-neurophysins response to apomorphine and clonidine in major depression

[en] A number of studies have reported abnormalities of neurohypophyseal secretions in major depressive disorder. The purpose of the present study was to test the influence of apomorphine and clonidine injections on plasma vasopressin (AVP)-neurophysins and oxytocin(OT)-neurophysins levels, as direct index of posterior pituitary activation in major depression. Apomorphine and clonidine tests were carried out in 25 medication-free depressive patients and 25 age and gender-matched healthy controls. Blood for neurophysins analysis was drawn by venipuncture at t0, t+20, t+40, t+60 and t+120. Baseline AVP-neurophysins concentrations were significantly tower in depressives (0.12 +/- 0.14 ng/ml) than in healthy subjects (0.24 +/- 2.15 ng/ml) (p < 0.04). The response to apomorphine test revealed a significant reduced response at 20 (p=0.01), 40 (p=0.007) and 60 (p=0.02) and 120 (p=0.02) min. Following clonidine test, post hoc tests also revealed a significant decrease at 0 (p=0.04), 20 (p=0.01), 40 (p=0.007) and 60 (p=0.02) and 120 (p=0.006) min. Concerning OT-neurophysins, no significant differences were found between depressed and controls in response to clonidine or apomorphine injections. Following clonidine and apomorphine, major depressives exhibited a significantly lower peak GH response than controls. The study supports partially the hypothesis of a reduced vasopressinergic activity in depression. Moreover, we did not find any influence of acute apomorphine or clonidine injections on vasopressin-neurophysin or oxytocin-neurophysin in depressive patients. (c) 2005 Elsevier Ltd. All rights reserved.

Disciplines :

Neurosciences & behavior
Endocrinology, metabolism & nutrition

Author, co-author :

Scantamburlo, Gabrielle ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Fuchs, Sonia

Pitchot, William ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Pinto, Emmanuel ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Reggers, Jean ; Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - PSYCHO & PSYCHIATRIE T3 -3E

Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

Legros, Jean-Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Language :

English

Title :

AVP- and OT-neurophysins response to apomorphine and clonidine in major depression

Publication date :

October 2005

Journal title :

Psychoneuroendocrinology

ISSN :

0306-4530

eISSN :

1873-3360

Publisher :

Pergamon-Elsevier Science Ltd, Oxford, United Kingdom

Volume :

Issue :

Pages :

839-845

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 10 February 2011

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