No full text
Paper published in a book (Scientific congresses and symposiums)
Multivariate analysis of cognitive profiles in Alzheimer's disease
Bastin, Christine; Leclercq, Yves; Collette, Fabienne et al.
2009In Proceedings of the 8th bi-annual Meeting of the Belgian Society for Neuroscience
Peer reviewed
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Alzheimer disease; cognition; heterogeneity
Abstract :
[en] The neuropsychological profiles of patients with early Alzheimer’s disease (AD) appear to be heterogeneous. In this study, we examined whether this heterogeneity corresponds to the existence of cognitively distinct subtypes of AD or rather to impairments along a continuum of performances in different cognitive domains. A large group of 187 AD patients recruited in the European project NEST-DD performed a neuropsychological battery. A factor analysis of cognitive performance identified three factors, which respectively reflected attentional/instrumental function, declarative memory and executive function. Three clustering methods were applied on the factor scores in order to explore the existence of separate groups. The clustering methods indicated that cognitive profiles among the patients were sufficiently variable to identify clusters, but there was continuity between clusters rather than clear-cut subtypes. Moreover, clusters corresponded to various combinations of relatively impaired and preserved functions, suggesting multidimensional distribution within a large population of patients. Finally, clusters of cognitive profiles were characterized by different levels of metabolism in brain regions commonly (but variably) involved or relatively preserved in AD.
Disciplines :
Neurosciences & behavior
Author, co-author :
Bastin, Christine  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Leclercq, Yves 
Collette, Fabienne  ;  Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Lemaire, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Aerts, Joël ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Perani, Daniela
Holthoff, Vjera
Beuthien-Baumann, B.
Sorbi, S.
Herholz, Karl
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Multivariate analysis of cognitive profiles in Alzheimer's disease
Publication date :
2009
Main work title :
Proceedings of the 8th bi-annual Meeting of the Belgian Society for Neuroscience
Pages :
52
Peer reviewed :
Peer reviewed
Available on ORBi :
since 05 February 2011

Statistics


Number of views
116 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Bibliography


Similar publications



Contact ORBi