Prolonged imiquimod treatment and graft-versus-host reaction: histological mimicry in the skin infiltration pattern of the monocyte-macrophage-dendrocyte lineage.

Hermanns-Lê, Trinh; Paquet, Philippe; Nikkels, Arjen; Pierard-Franchimont, Claudine; Pierard, Gérald

doi:10.1159/000069958

Article (Scientific journals)

Prolonged imiquimod treatment and graft-versus-host reaction: histological mimicry in the skin infiltration pattern of the monocyte-macrophage-dendrocyte lineage.

Hermanns-Lê, Trinh; Paquet, Philippe; Nikkels, Arjen et al.

2003 • In Dermatology, 206 (4), p. 361-365

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/8382

DOI
10.1159/000069958

PubMed
12771487

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Keywords :

Adult; Aminoquinolines/therapeutic use; Antineoplastic Agents/therapeutic use; Carcinoma, Basal Cell/drug therapy; Dendritic Cells/immunology; Graft vs Host Reaction/immunology; Humans; Immunohistochemistry; Macrophages/immunology; Middle Aged; Monocytes/immunology; Skin/cytology/drug effects; Skin Neoplasms/drug therapy; Tumor Necrosis Factor-alpha/analysis

Abstract :

[en] Factor-XIIIa-positive dendrocytes belong to the monocyte-macrophage-dendrocyte (MMD) lineage which is considered to play a pivotal role in the skin response to the immune response modifier imiquimod. The same cells are also boosted in low-grade graft-versus-host reaction (GVHR) with skin manifestations. Both conditions are characterized by specific epidermal damage. The aim of the present study was to compare them using immunohistochemistry to identify MMD subsets and other inflammatory cells in the dermis. We compared 3 cases of long-term (4, 9 and 11 months) imiquimod topical applications on normal skin, 25 low-grade GVHR controlled by immunosuppressive therapy and 25 control cases with normal skin. Compared to the normal dermis, cells of the MMD lineage were considerably boosted in the dermis of GVHR and at the imiquimod-treated sites. By contrast, only minimal accumulations of lymphocytes and Langerhans cells were disclosed in the dermis. The pattern of dermal infiltration by MMD cells was similar in GVHR and after imiquimod treatment. However, intraindividual differences in densities were obvious irrespective of the skin condition. In conclusion, there is great mimicry in the MMD involvement in the dermis during low-grade GVHR and after chronic applications of imiquimod.

Disciplines :

Dermatology

Author, co-author :

Hermanns-Lê, Trinh ; Université de Liège - ULiège > Dermatopathologie

Paquet, Philippe ; Université de Liège - ULiège > Dermatopathologie

Nikkels, Arjen ; Université de Liège - ULiège > Dermatologie

Pierard-Franchimont, Claudine ; Université de Liège - ULiège > Dermatopathologie

Pierard, Gérald ; Université de Liège - ULiège > Dermatopathologie

Language :

English

Title :

Prolonged imiquimod treatment and graft-versus-host reaction: histological mimicry in the skin infiltration pattern of the monocyte-macrophage-dendrocyte lineage.

Publication date :

2003

Journal title :

Dermatology

ISSN :

1018-8665

eISSN :

1421-9832

Publisher :

S. Karger, Basel, Switzerland

Volume :

206

Issue :

Pages :

361-365

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 11 March 2009

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